Using Anterior Segment Optical Coherence Tomography to Monitor Disease Progression in Peripheral Ulcerative Keratitis

Garg, Aakriti; Rojas, J.De La Higuera; Mathews, Priya; Hazan, Albert; Lin, James; Trief, Danielle; Suh, Leejee H.

doi:10.1155/2018/3705753

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…As described by others, although in the context of peripheral inflammatory corneal disease, AS-OCT aided us in monitoring progressive structural changes in the peripheral cornea, such as increased hyperreflectivity of lesions and geographic assessment of corneal thickness. 14 Finally, AS-OCT visualization of the observed lesions bolstered our working diagnosis and obviated the need for an invasive procedure, such as polymerase chain reaction testing and/or corneal biopsy, in a pediatric patient. We recommend that treating providers exercise best clinical judgment regarding what type of testing to ultimately initiate, keeping in mind the favorable results we had in our patient relying on AS-OCT and laboratory testing alone.…”

Section: Discussionmentioning

confidence: 97%

Anterior segment OCT findings and atypical refractive changes secondary to Epstein-Barr virus–associated nummular keratitis

Khan

Murphy

John

et al. 2022

JCRS Online Case Rep

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Introduction: This case study described refractive changes that can occur in the setting of Epstein-Barr virus (EBV)-associated nummular keratitis (NK) and highlighted the role that anterior segment optical coherence tomography can serve in diagnosis and management of this disease. Patient and Clinical Findings:A 15-year-old girl developed subepithelial and anterior stromal corneal lesions and experienced progressive decline in the corrected distance visual acuity. She also developed a significant myopic shift with increased keratometric and refractive astigmatism.Diagnosis, Intervention, and Outcomes Targeted laboratory testing was performed. A diagnosis of chronic EBV-associated NK was made, and the patient was treated with systemic valacyclovir and topical steroids. Clinical appearance of lesions and corrected distance visual acuity improved, although refractive and keratometric changes persisted.Conclusions: Significant and persistent refractive changes can occur in the setting of EBV-associated NK, similar to those seen after conductive keratoplasty. Anterior segment optical coherence tomography can be a potentially helpful supplementary diagnostic imaging modality to avoid invasive testing in such cases.

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Section: Discussionmentioning

confidence: 97%

Anterior segment OCT findings and atypical refractive changes secondary to Epstein-Barr virus–associated nummular keratitis

Khan

Murphy

John

et al. 2022

JCRS Online Case Rep

View full text Add to dashboard Cite

show abstract

“…As the inflammation intensity declines, irregular hyporeflective epithelium, a smoother anterior stroma, and a homogeneous hyperreflective stroma can be seen. On the other hand, healed PUK lesion is characterized by a filled corneal defect with a hyporeflective thick epithelium, a demarcation line, and the persistence of the hyperreflective underlying stroma [35,36].…”

Section: Clinical Presentationmentioning

confidence: 99%

Peripheral Ulcerative Keratitis Associated with Autoimmune Diseases

Świerczyńska,

Tronina,

Mrukwa-Kominek

2024

Keratitis - Current Perspectives

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Peripheral ulcerative keratitis (PUK) is a destructive inflammatory disease of the juxtalimbal cornea associated with crescent-shaped corneal stromal thinning, epithelial defect, and inflammatory corneal infiltrate. Inflammation of other adjacent tissues, particularly the sclera, is seen quite frequently. Predilection of the peripheral cornea for PUK is explained by its anatomical and physiological characteristics. Both cell-mediated and humoral immunity, in conjunction with the corneal tissue-destroying action of metalloproteinases (MMPs), are implicated in the pathogenesis of PUK. Nearly half of all cases of noninfectious PUK are associated with connective tissue diseases (rheumatoid arthritis (RA) is the most frequent underlying disease) and vasculitis (mostly granulomatous with polyangiitis (GPA)). It is important to determine the etiology and exclude conditions that could mimic PUK e.g., marginal keratitis or Terrien’s marginal degeneration (TMD). Therapy should comprise the attenuation of ophthalmic inflammation, but the underlying disease should be treated as a priority. For autoimmune diseases, it is crucial to work closely with internist/rheumatologist to determine an effective immunomodulatory therapeutic approach. PUK is also known to be a potentially devastating and vision-threatening condition that may lead to corneal melting and perforation, requiring surgical intervention. This chapter provides a comprehensive update of current knowledge and therapeutic methods.

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Hierarchy-Constrained Network for Corneal Tissue Segmentation Based on Anterior Segment OCT Images

Liu¹,

Guo³

et al. 2020

2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI)

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Using Anterior Segment Optical Coherence Tomography to Monitor Disease Progression in Peripheral Ulcerative Keratitis

Cited by 3 publications

References 13 publications

Anterior segment OCT findings and atypical refractive changes secondary to Epstein-Barr virus–associated nummular keratitis

Anterior segment OCT findings and atypical refractive changes secondary to Epstein-Barr virus–associated nummular keratitis

Peripheral Ulcerative Keratitis Associated with Autoimmune Diseases

Hierarchy-Constrained Network for Corneal Tissue Segmentation Based on Anterior Segment OCT Images

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