Usefulness of the LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile

Kaneva, Anastasiya M.; Потолицына, Н. Н.; Bojko, Evgeny R.

doi:10.1080/13813455.2016.1195411

Cited by 27 publications

(24 citation statements)

References 48 publications

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“…An LDL-C/apoB ratio of 1.2 has been suggested to correspond to an LDL diameter of 25.5 nm, which is the cut-off value for distinguishing LDL pattern A (large buoyant LDL) from LDL pattern B [small dense (sd)-LDL] [ 7 , 8 ], indicating the presence of a large quantity of sd-LDL. In fact, the Québec Cardiovascular Study demonstrated that in patients with LDL-particle sizes of 25.5 nm or smaller, the CAD incidence increased significantly as the serum LDL-C level increased, while in patients having large LDL-particle sizes of 26.0 nm or greater, no significant difference in CAD events was observed according to the absolute serum LDL-C level [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Relation between low-density lipoprotein cholesterol/apolipoprotein B ratio and triglyceride-rich lipoproteins in patients with coronary artery disease and type 2 diabetes mellitus: a cross-sectional study

Tani

Yagi

Atsumi

et al. 2017

Cardiovasc Diabetol

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BackgroundThe low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio has conventionally been used as an index of the LDL-particle size. Smaller LDL-particle size is associated with triglyceride (TG) metabolism disorders, often leading to atherogenesis. We investigated the association between the LDL-C/apoB ratio and TG metabolism in coronary artery disease (CAD) patients with diabetes mellitus (DM).MethodsIn the cross-sectional study, the LDL-C/apoB ratio, which provides an estimate of the LDL-particle size, was calculated in 684 consecutive patients with one additional risk factor. The patients were classified into 4 groups based on the presence or absence of CAD and DM, as follows: CAD (−) DM (−) group, n = 416; CAD (−) DM (+) group, n = 118; CAD (+) DM (−) group, n = 90; CAD (+) DM (+) group, n = 60.ResultsA multi-logistic regression analysis after adjustments for coronary risk factors revealed that the CAD (+) DM (+) condition was an independent predictor of the smallest LDL-C/apoB ratio among the four groups. Furthermore, multivariate regression analyses identified elevated TG-rich lipoprotein (TRL)-related markers (TG, very-LDL fraction, remnant-like particle cholesterol, apolipoprotein C-II, and apolipoprotein C-III) as being independently predictive of a smaller LDL-particle size in both the overall subject population and a subset of patients with a serum LDL-C level < 100 mg/dL. In the 445 patients followed up for at least 6 months, multi-logistic regression analyses identified increased levels of TRL-related markers as being independently predictive of a decreased LDL-C/apoB ratio, which is indicative of smaller LDL-particle size.ConclusionsThe association between disorders of TG metabolism and LDL heterogeneity may account for the risk of CAD in patients with DM. Combined evaluation of TRL-related markers and the LDL-C/apoB ratio may be of increasing importance in the risk stratification of CAD patients with DM. Further studies are needed to investigate the useful clinical indices and outcomes of these patients. Clinical Trial Registration UMIN (http://www.umin.ac.jp/) Study ID: UMIN000028029 retrospectively registered 1 July 2017

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Section: Introductionmentioning

confidence: 99%

Relation between low-density lipoprotein cholesterol/apolipoprotein B ratio and triglyceride-rich lipoproteins in patients with coronary artery disease and type 2 diabetes mellitus: a cross-sectional study

Tani

Yagi

Atsumi

et al. 2017

Cardiovasc Diabetol

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“…An LDL-C/ApoB ratio lower than 1.2 may be used for distinguishing large buoyant LDL from small dense LDL. The incidence of CHD increases significantly in patients with small LDL-particle sizes[11, 12, 24, 25]. In the current cohort study, the results of the logistic regression analysis revealed that low LDL-C/Apo B ratio is an independent predictor of CHD.…”

Section: Discussionmentioning

confidence: 66%

LDL/Apo B ratio and Lp (a) Each Predict Coronary Artery Disease in Type2 Diabetes Independent of ASCVD Risk Score: A Case-Cohort Study

Rabizadeh

Rajab

Mechanick

et al. 2020

Preprint

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Aim: To evaluate the predictive value of the LDL/ApoB ratio for coronary heart disease (CHD) in patients with type2 diabetes (T2D). Methods: In this case-cohort study, (apo)lipoproteins and glycemic indices were measured in 1058 individuals with T2D from February 2002 to March 2019, with a median duration of follow up of 10 years. Results: Of 1058 patients with T2D, coronary heart disease occurred in 242 patients. Increased waist circumference, waist to hip ratio, and hemoglobin A1c, low-density lipoprotein cholesterol (LDL)/Apolipoprotein B (ApoB) ratio, presence of hypertension and metabolic syndrome, and insulin and statin use were more prevalent among patients with CHD (P<0.001). Logistic regression analysis showed that an LDL/ApoB ratio equal or lower than 1.2, as well as a Lp(a) cutoff level more than 25.45 mg/dl could each predict CHD independent of ASCVD risk score [adjusted OR:1.841, CI:1.257 to 2.698, P<0.001 and adjusted OR: 1.433, CI:1.014 to 2.026, P=0.041) respectively ] when adjusted for multiple confounders.The atherogenic index of plasma (AIP) did not predict CHD. Conclusion: This study showed that LDL/ApoB ratio and Lp(a) each, but not the atherogenic index of plasma, may be considered as an indicator of CHD independent of ASCVD risk score in patients with T2D. This finding merits further clarification to optimize preventive strategies for CHD.

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“…sd‐LDL ELISAs are currently still expensive and their elaborate process makes them impractical for implementation within clinical routine; ApoB is a more feasible test to perform within a clinical setting. Studies suggest that the ApoB to LDL ratio may be a useful tool for assessing the overall atherogenicity of a lipid profile . Some interventional methods to explore in future studies include differing diets, physical activity, antioxidant supplementation with Omega‐3, and the administration of statins.…”

Section: Should We Therefore Favor a Tacrolimus‐ And Mmf‐based Immunomentioning

confidence: 99%

Improving long‐term outcomes after pediatric renal transplantation by addressing dyslipidemia

Filler

Medeiros

2017

Pediatric Transplantation

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Usefulness of the LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile

Cited by 27 publications

References 48 publications

Relation between low-density lipoprotein cholesterol/apolipoprotein B ratio and triglyceride-rich lipoproteins in patients with coronary artery disease and type 2 diabetes mellitus: a cross-sectional study

Relation between low-density lipoprotein cholesterol/apolipoprotein B ratio and triglyceride-rich lipoproteins in patients with coronary artery disease and type 2 diabetes mellitus: a cross-sectional study

LDL/Apo B ratio and Lp (a) Each Predict Coronary Artery Disease in Type2 Diabetes Independent of ASCVD Risk Score: A Case-Cohort Study

Improving long‐term outcomes after pediatric renal transplantation by addressing dyslipidemia

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