Usefulness of the dacryoscintigraphy in patients with nasolacrimal duct obstruction prior to endoscopic dacryocystorhinostomy

Kim, Dong Ju; Baek, Sehyun; Chang, Minwook

doi:10.1007/s00417-019-04303-4

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Classifying patients with primary NLDO by DSG does not appear to predict anatomic or functional success rates, although DSG is recognized as a sensitive test for initial assessment of anatomic obstruction 15,16 . In contrast, classifying functional cases using DSG has been shown to accurately predict outcomes.…”

Section: Discussionmentioning

confidence: 97%

“…14 Classifying patients with primary NLDO by DSG does not appear to predict anatomic or functional success rates, although DSG is recognized as a sensitive test for initial assessment of anatomic obstruction. 15,16 In contrast, classifying functional cases using DSG has been shown to accurately predict outcomes. Distal duct obstructions have been found to respond very favorably to silicone tube intubations, while patients with proximal duct and prelacrimal sac involvement may warrant alternative treatments or further adjunctive therapies.…”

Section: Discussionmentioning

confidence: 99%

“…Distal duct obstructions have been found to respond very favorably to silicone tube intubations, while patients with proximal duct and prelacrimal sac involvement may warrant alternative treatments or further adjunctive therapies. 15 However, an important consideration in the use of DSG is the lack of consensus terminology for the interpretation of these scans. It has been shown that there is only moderate interobserver agreement between surgeons and nuclear medicine, particularly in cases that had abnormal syringing.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned, intubation alone can be effective in specific cases involving the distal ducts and is commonly used in combination with DCR or following functional failure of DCR. 7,15 Balloon dacryoplasty involves serial dilation of the duct and has lower success rates but should be considered particularly as a less invasive revision option after failed DCR or if surgery or anesthesia is contraindicated. 18,19 Lower lid tightening has shown up to 50% success, even with laxity as low as 6 to 10 mm.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of Endonasal Dacryocystorhinostomy Performed for Functional Nasolacrimal Obstruction With Delay on Dacryoscintigraphy

Hodgson,

Hussain

2023

Journal of Craniofacial Surgery

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Purpose: To report the demographics and outcomes of endonasal dacryocystorhinostomy (DCR) following dacryoscintigraphy (DSG) performed for a series of patients with functional epiphora. Methods: Case series of endonasal DCR outcomes in patients with symptomatic epiphora with no evidence of lacrimal hypersecretion or lacrimal pump failure, minimal regurgitation noted on syringing, and DSG-confirmed delayed drainage. A successful outcome was defined as 80% subjective improvement or resolution of tearing on the operated side. Patient charts, DSG results, and operative records were examined, and data were collected. Relevant literature was reviewed and discussed. Results: The case series included 15 eyes of 10 patients. The mean age was 61.7 years at the time of surgery. Most cases (n=13) had post-sac obstruction, retention, or delay. One patient had pre and post-sac retention. A total of 12 cases had success after endonasal DCR, and 3 cases had failure. Follow-up for all operated patients was over 6 months. There were no reported complications by the surgeon or patients. Conclusions: Patients with functional epiphora confirmed by DSG seem to have a high success rate after endonasal DCR. In patients with symptomatic epiphora with subjective patency on syringing, the use of DSG in decision-making and outcome prediction may be supported. Further studies, including clinic-based tests, to demonstrate functional obstruction are warranted.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Outcomes of Endonasal Dacryocystorhinostomy Performed for Functional Nasolacrimal Obstruction With Delay on Dacryoscintigraphy

Hodgson,

Hussain

2023

Journal of Craniofacial Surgery

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“…Gamma scintigraphy was first assessed by Rossomondo et al in 1972 [56], and was later used with modifications in preclinical studies [57] and in humans [58,59,60,61,62] to assess the lacrimal drainage and the lacrimal gland inflammation [63]. Subsequently, it has been used with the aim of understanding the ocular surface biodistribution of different formulations used as drug delivery vehicles in mice and humans, as it is the case for artificial lacrimal products that contain hydroxypropyl methylcellulose (HPMC), a combination of PVA and gellan gum for antiglaucoma drug release [64,65], PVA [66,67,68] or sodium hyaluronate [69].…”

Section: Spectmentioning

confidence: 99%

Ocular Biodistribution Studies Using Molecular Imaging

et al. 2019

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Classical methodologies used in ocular pharmacokinetics studies have difficulties to obtain information about topical and intraocular distribution and clearance of drugs and formulations. This is associated with multiple factors related to ophthalmic physiology, as well as the complexity and invasiveness intrinsic to the sampling. Molecular imaging is a new diagnostic discipline for in vivo imaging, which is emerging and spreading rapidly. Recent developments in molecular imaging techniques, such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), allow obtaining reliable pharmacokinetic data, which can be translated into improving the permanence of the ophthalmic drugs in its action site, leading to dosage optimisation. They can be used to study either topical or intraocular administration. With these techniques it is possible to obtain real-time visualisation, localisation, characterisation and quantification of the compounds after their administration, all in a reliable, safe and non-invasive way. None of these novel techniques presents simultaneously high sensitivity and specificity, but it is possible to study biological procedures with the information provided when the techniques are combined. With the results obtained, it is possible to assume that molecular imaging techniques are postulated as a resource with great potential for the research and development of new drugs and ophthalmic delivery systems.

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Nasolacrimal Duct Obstruction

Lachmund

2023

Advances in Ophthalmology and Optometry

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Usefulness of the dacryoscintigraphy in patients with nasolacrimal duct obstruction prior to endoscopic dacryocystorhinostomy

Cited by 5 publications

References 23 publications

Outcomes of Endonasal Dacryocystorhinostomy Performed for Functional Nasolacrimal Obstruction With Delay on Dacryoscintigraphy

Outcomes of Endonasal Dacryocystorhinostomy Performed for Functional Nasolacrimal Obstruction With Delay on Dacryoscintigraphy

Ocular Biodistribution Studies Using Molecular Imaging

Nasolacrimal Duct Obstruction

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