Usefulness of presepsin / creatinine ratio as a new index that corrects for renal function

Miyoshi, Masashi; Inoue, Yusuke; Nishioka, Mai; Ikegame, Akishige; Nakao, Toshihiro; Takayama, Tetsuji; Nagai, Kojiro

doi:10.2152/jmi.68.105

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…Based on its molecular weight, it is assumed that presepsin is reabsorbed and catabolised within proximal tubular cells after being filtered by the glomerulus. As a result, any condition that impairs renal filtration or tubular function could impact blood presepsin concentration and raise its plasmatic levels 20 …”

Section: Discussionmentioning

confidence: 99%

Perinatal asphyxia does not influence presepsin levels in neonates: A prospective study

Maddaloni,

De Rose,

Perulli

et al. 2023

Acta Paediatrica

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AimTo compare Presepsin (presepsin) levels in plasma and urine of uninfected newborn infants with perinatal asphyxia with those of controls.MethodsIn this prospective study, we enrolled 25 uninfected full‐term infants with perinatal asphyxia and 19 controls. We measured presepsin levels in whole blood or urine. In neonates with perinatal asphyxia, we compared presepsin levels in blood and urine at four time points.ResultsIn neonates with perinatal asphyxia, blood and urinary presepsin levels matched each other at any time point. At admission, the median presepsin value in blood was similar in both groups (p = 0.74), while urinary levels were higher in hypoxic neonates (p = 0.05). Perinatal asphyxia seemed to increase serum CRP and procalcitonin levels beyond normal cut‐off but not those of presepsin.ConclusionIn uninfected neonates with perinatal asphyxia, median blood and urinary presepsin levels matched each other at any point in the first 72 h of life and seemed to be slightly affected by the transient renal impairment associated with perinatal hypoxia in the first 12 h of life. Perinatal asphyxia did not influence presepsin levels within the first 72 h of life, while those of CRP and procalcitonin increased.

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Section: Discussionmentioning

confidence: 99%

Perinatal asphyxia does not influence presepsin levels in neonates: A prospective study

Maddaloni,

De Rose,

Perulli

et al. 2023

Acta Paediatrica

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“…Sep-3 has been proposed as a new diagnostic criterion for sepsis, and thus future studies on the diagnostic accuracy of Pre based on the Sep-3 criterion are needed. Considering the relationship between Pre and renal function, a recent study reported that the Pre/serum Cr ratio did not depend on the GFR stage, and the reference ratio was 67–263, which was significantly higher in patients with sepsis [ 18 ]. More studies are needed to investigate whether the Pre/Cr ratio or a different cut-off setting for patients with advanced renal impairment is more useful for the diagnosis of sepsis in patients with renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…263, which was significantly higher in patients with sepsis [18]. More studies are needed to investigate whether the Pre/Cr ratio or a different cut-off setting for patients with advanced renal impairment is more useful for the diagnosis of sepsis in patients with renal dysfunction.…”

Section: Plos Onementioning

confidence: 96%

Presepsin cut-off value for diagnosis of sepsis in patients with renal dysfunction

et al. 2022

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Presepsin is used as a marker for diagnosing sepsis, but its serum concentration is affected by renal function. We investigated the effect of the estimated glomerular filtration rate (eGFR) determined by creatinine on the diagnostic accuracy of presepsin to identify the optimal cut-off value in patients with renal dysfunction. A total of 834 patients aged ≥18 years with serum presepsin and creatinine measured on the same day over a period of 1 year were included. Sepsis was diagnosed in three ways: sepsis-1, sepsis-3, and clinical diagnosis (Sep-C). Presepsin showed a significant negative correlation with eGFR (r = −0.55, p<0.01), with median and interquartile ranges of presepsin values for patients in each eGFR category as follows: ≥90, 263 (169–460); ≥60–<90, 309 (205–578); ≥45–<60, 406 (279–683); ≥30–<45, 605 (379–1109); ≥15–<30, 1027 (675–1953); <15, 1977 (1199–3477); and on hemodialysis, 3964 (2343–6967). In receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for sepsis-1 was the lowest (0.64 ± 0.02), while Sep-C (0.80± 0.03) and sepsis-3 (0.75 ± 0.03) were moderately accurate. Comparing AUCs after dividing patients into eGFR ≥60 and <60 showed that the AUC of Sep-C was lower in the eGFR ≥60 group, while the AUC of sepsis-3 was ≥ 0.7 in both groups. The following cut-offs were obtained by ROC analysis for sepsis-3: 466 pg/mL in the ≥60 group and 960 pg/mLin the < 60 group. Presepsin facilitated diagnosis sepsis based on sepsis-3 criteria regardless of renal function. We found that the optimal cut-offs for patients in this study were 500 pg/mL for eGFR ≥ 60 and 1000 pg/mL for < 60. However, future prospective diagnostic studies on sepsis-3 are needed to determine the cut-offs for patients with renal dysfunction.

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“…У пациентов с тяжелой почечной недостаточностью оптимальные пороговые значения пресепсина составляли 500 нг/л (диагностическая чувствительность -89,7%, диагностическая специфичность -59,7%). Таким образом, значения пресепсина были выше в группе пациентов с тяжелой почечной недостаточностью по сравнению с таковыми у здоровых пациентов [28].…”

Section: пресепсинunclassified

A Clinician’s Perspective on the Use of Laboratory Markers of Sepsis

Якубцевич¹,

Лемеш²

2022

Лабораторная Диагностика. Восточная Европа

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Сепсис представляет собой опасное для жизни состояние, вызванное нарушением ответной реакции организма хозяина на инфекцию, приводящую к дисфункции жизненно важных органов и систем. Сепсис и септический шок, ежегодно поражающие миллионы людей во всем мире, являются серьезными проблемами здравоохранения. Современные успехи в изучении патогенетических механизмов формирования сепсиса напрямую связаны с оптимизацией технологий лабораторной диагностики данной патологии. Хотя в настоящее время не существует «золотого стандарта» диагностики и прогнозирования развития сепсиса, наибольший клинический интерес привлекают лабораторно-диагностические тесты, многие из которых обладают высокой диагностической чувствительностью и диагностической специфичностью в отношении выявления у пациентов септического состояния, а также являющиеся достаточной альтернативой шкале SOFA, используемой для оценки выраженности органной недостаточности и прогнозирования смертности пациентов с сепсисом. Поэтому в настоящее время усилия медиков направлены на поиск новых, более эффективных, чем известные ранее, биомаркеров диагностики, мониторинга, прогнозирования прогрессирования и исхода сепсиса. В данном обзоре представлена информация о традиционно используемых и перспективных лабораторных тестах диагностики септических состояний с позиций врачей-клиницистов, часто встречающихся с ними по роду своей профессиональной деятельности. Sepsis is a life-threatening condition caused by an impaired host response to an infection, resulting in dysfunction of vital organs and systems. Sepsis and septic shock, which affect millions of people worldwide every year, are serious public health problems. Modern advances in the study of the pathogenetic mechanisms of the formation of sepsis are directly related to the optimization of technologies for laboratory diagnosis of this pathology. Although there is currently no "gold standard" for diagnosing and predicting the development of sepsis, the greatest clinical interest is attracted by laboratory diagnostic tests, many of which have high diagnostic sensitivity and diagnostic specificity for detecting septic condition in patient, being also a suitable alternative to the SOFA scale used to assess the severity of organ failure and predict mortality in sepsis patients. This review provides information on traditionally used and promising laboratory tests for diagnosis of septic conditions from the standpoint of clinicians encountering them frequently in their professional activities.

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Usefulness of presepsin / creatinine ratio as a new index that corrects for renal function

Cited by 5 publications

References 19 publications

Perinatal asphyxia does not influence presepsin levels in neonates: A prospective study

Perinatal asphyxia does not influence presepsin levels in neonates: A prospective study

Presepsin cut-off value for diagnosis of sepsis in patients with renal dysfunction

A Clinician’s Perspective on the Use of Laboratory Markers of Sepsis

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