Usefulness of Palatinose as a Caloric Sweetener for Diabetic Patients

Kawai, Koichi; Yoshikawa, Hiroko; Murayama, Yasuko; Okuda, Yukichi; Yamashita, Keisuke

doi:10.1055/s-2007-1009230

Cited by 83 publications

(57 citation statements)

References 4 publications

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“…The rats were placed in the chamber immediately after the oral administration of [1-13 C]sucrose or [1][2][3][4][5][6][7][8][9][10][11][12][13] C]palatinose at a dose of 2 g/kg (mixture of 0·175 g of [1- Schematic illustration of the system used to collect expired air from rats. Briefly, this system composed of a desiccator that was used as an animal chamber, a pump and breath sampling bags.…”

Section: C-breath Testmentioning

confidence: 99%

Studies on absorption and metabolism of palatinose (isomaltulose) in rats

Tonouchi¹,

Yamaji²,

Uchida³

et al. 2010

Br J Nutr

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We evaluated the absorption and metabolism of palatinose in rats by the carbohydrate load test and the 13 C-and H 2 -breath tests. We compared the results of these tests with those of sucrose, since sucrose is an isomer of palatinose and generally known to be degraded and absorbed from the small intestine. In the carbohydrate load test, blood glucose and plasma insulin levels after oral administration of palatinose rose more gradually and reached a maximum that was lower than that after sucrose administration. C fru ] showed no difference between palatinose and sucrose. In the H 2 -breath test, the concentration of H 2 in the expired air was measured for 420 min. H 2 was hardly detected with both palatinose and sucrose and no significant difference was observed between the two groups. These results suggest that palatinose is utilised in vivo at a rate equal to that of sucrose.

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Section: C-breath Testmentioning

confidence: 99%

Studies on absorption and metabolism of palatinose (isomaltulose) in rats

Tonouchi¹,

Yamaji²,

Uchida³

et al. 2010

Br J Nutr

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“…Os resultados demonstraram que a isomaltulose é absorvida mais lentamente que a sacarose, sendo indicada como adoçante para pacientes diabéticos. Posteriormente foi demonstrado em experimentos in vitro, com mucosa intestinal humana, que o valor da digestão da isomaltulose foi cinco vezes menor quando comparado com a da sacarose 86 . Em estudos in vivo foi demonstrado que a administração oral de isomaltulose (1 g/kg) provocou um leve aumento na glicose e insulina do plasma.…”

Section: Propriedades Nutrição E Metabolismo Da Isomaltuloseunclassified

Produção de isomaltulose, um substituto da sacarose, utilizando glicosiltransferase microbiana

Kawaguti¹,

Sato²

2008

Quím. Nova

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“…It had also been confirmed that with sucrose the level of glucose reached peak value at 30-60 min after the administration and returned to the initial value 90-120 min after administration, with some individual variations in the elapsed time. On the other hand, with palatinose, the level of glucose smoothly rose at 30-60 min after administration and decreased thereafter but did not fall to the initial value at 90-120 min (Kawai et al, 1989). Effects of ␣ wave generation were thought to arise after the changes in blood glucose.…”

Section: Methodsmentioning

confidence: 99%

“…The area of ␣1 wave generation increased slightly but less than that in 40 g palatinose group. The above results suggested that palatinose enhances generation of ␣ waves and that its effect might be maintained longer than that of sucrose.Keywords: palatinose, brain waves, ␣1 waves Palatinose (1-O-␣-D-glucopyranosyl-D-fructose, isomaltulose) is used as an ingredient for functional foods because of its physiological characteristics; for example, it is non-cariogenic (Minami et al, 1990; Ooshima et al, 1983a, b), causes a gradual increase in blood glucose level and a slight secretion of insulin (Kawai et al, 1989). Palatinose is a structural isomer of sucrose and a disaccharide composed of glucose and fructose with an ␣-1, 6 bond.…”

mentioning

confidence: 99%

Effect of Palatinose Administration on .ALPHA.1 Brain Waves in Human Volunteers

Nagai

Sato

Kashimura

et al. 2003

FSTR

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The effect of palatinose intake on ␣1 brain wave generation was studied by human volunteer test. Twelve healthy volunteers were administered 40 g of palatinose or sucrose, and electroencephalogram (EEG) was made before and at 150 min after administration. The area of ␣1 wave generation on topographs increased after administration of either sugar, but there was a significant difference in the intensity between the palatinose and sucrose groups. Ten volunteers were administered 100 mg of theanine, which has a relaxing effect, in combination with 17.5 g of palatinose (T-P group), and EEGs were recorded before, at 60 and 150 min after administration. Though the area of generated ␣1 brain wave in the topographs increased in both groups (T-P and 17.5 g palatinose groups) after administration, the patterns of their increase differed. Nine volunteers were administered 5 g of palatinose, and EEGs were recorded before and at 150 min after the administration. The area of ␣1 wave generation increased slightly but less than that in 40 g palatinose group. The above results suggested that palatinose enhances generation of ␣ waves and that its effect might be maintained longer than that of sucrose.Keywords: palatinose, brain waves, ␣1 waves Palatinose (1-O-␣-D-glucopyranosyl-D-fructose, isomaltulose) is used as an ingredient for functional foods because of its physiological characteristics; for example, it is non-cariogenic (Minami et al., 1990; Ooshima et al., 1983a, b), causes a gradual increase in blood glucose level and a slight secretion of insulin (Kawai et al., 1989). Palatinose is a structural isomer of sucrose and a disaccharide composed of glucose and fructose with an ␣-1, 6 bond. Sucrose and glucose are known to change into blood glucose after ingestion and are utilized as the energy source for the brain. Recent studies have shown that the mental state (emotion, mood) in human is strongly related to the blood glucose level and glucose supply to the brain (Benton, 1998;Keul et al., 1982;Martin & Benton, 1999). Palatinose, which differs from sucrose in the time-course change of blood glucose level, is believed to have a different effect on the mental state of humans. This was the reason the effect of palatinose administration on mental concentration was investigated by Kashimura et al. (2003).In today's stressful society there are various products promoting relaxation, and there are several ongoing studies about the relaxing effects of elements that directly appeal to the five senses: visual, images, music, flavor and taste (Kawano, 2000;Kawaki et al., 1998;Nagai, 2002). Various flavoring and seasoning ingredients are used in commercial foods claiming to have a relaxing effect, however, these sometimes do not meet people's preferences. Thus, there are studies focusing on substances such as theanine contained in green tea, which affect the release or decline of neurotransmitters in the brain, even when taken in a concentration which is not high enough to impart taste (Juneja et al., 1999;Kobayashi et al., 1998;Yokogoshi...

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Usefulness of Palatinose as a Caloric Sweetener for Diabetic Patients

Cited by 83 publications

References 4 publications

Studies on absorption and metabolism of palatinose (isomaltulose) in rats

Studies on absorption and metabolism of palatinose (isomaltulose) in rats

Produção de isomaltulose, um substituto da sacarose, utilizando glicosiltransferase microbiana

Effect of Palatinose Administration on .ALPHA.1 Brain Waves in Human Volunteers

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