Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas

Sugahara, Takeshi; Korogi, Yukunori; Kochi, Masato; Ikushima, Ichiro; Shigematu, Yoshinori; Hirai, Toshinori; Okuda, Tomoko; Liang, Luxia; Ge, Yulin; Komohara, Yasuyuki; Ushio, Yukitaka; Takahashi, Manabu

doi:10.1002/(sici)1522-2586(199901)9:1<53::aid-jmri7>3.0.co;2-2

Cited by 1,046 publications

(766 citation statements)

References 18 publications

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“…The apparent diffusion coefficient (ADC) measured using DWI has been shown to be inversely associated with cell density [29,30], as water diffusivity is restricted with increased cell density and barriers to free water mobility. Consistent with this observation, several studies have demonstrated progressive tumor exhibiting lower ADC (~1.0-1.3 µm 2 /ms) compared with pseudoprogression (>1.3 µm 2 /ms) [31][32][33].…”

Section: Diffusion Mrimentioning

confidence: 99%

Pseudoprogression, radionecrosis, inflammation or true tumor progression? challenges associated with glioblastoma response assessment in an evolving therapeutic landscape

et al. 2017

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Section: Diffusion Mrimentioning

confidence: 99%

Pseudoprogression, radionecrosis, inflammation or true tumor progression? challenges associated with glioblastoma response assessment in an evolving therapeutic landscape

et al. 2017

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“…Malignant tumors in general have a higher cellularity than benign lesions. Studies associating diffusion imaging and assessment of cellularity have been done in liver, brain, and breast lesions (17)(18)(19)(20)(21). In these organs, DWI seems to help differentiate malignant and benign lesions.…”

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confidence: 99%

Quantitative diffusion imaging in breast cancer: A clinical prospective study

Rubesova

Grell

Maertelaer

et al. 2006

Magnetic Resonance Imaging

228

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Purpose: To study the correlation between apparent diffusion coefficient (ADC) and pathology in patients with undefined breast lesion, to validate how accurately ADC is related to histology, and to define a threshold value of ADC to distinguish malignant from benign lesions. Materials and Methods:Seventy-eight patients (110 lesions) were referred for positive or dubious findings. Threedimensional fast low-angle shot (3D-FLASH) with contrast injection was applied. EPI diffusion-weighted imaging (DWI) with fat saturation was performed, and ROIs were selected on subtraction 3D-FLASH images before and after contrast injection, and copied on an ADC map. Inter-and intraobserver analyses were performed.Results: At pathology 22 lesions were benign, 65 were malignant, and 23 were excluded. The ADCs of malignant and benign lesions were statistically different. In malignant tumors the ADC was (mean Ϯ SEM) 0.95 Ϯ 0.027 ϫ 10 -3mm 2 /second, and in benign tumors it was 1.51 Ϯ 0.068 ϫ 10 -3 mm 2 /second. According to receiver operating characteristic (ROC) curves, we found a threshold between malignant and benign lesions for highest sensitivity and specificity (both 86%) around 1.13 Ϯ 0.10 ϫ 10 -3 mm 2 /second. For a threshold of 0.95 Ϯ 0.10 ϫ 10 -3 mm 2 /second, specificity was 100% but sensitivity was very low. Inter-and intraobserver studies showed good reproducibility. Conclusion:The ADC may help to differentiate benign and malignant lesions with good specificity, and may increase the overall specificity of breast MRI.

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“…In addition, an ADC map showed the renal cancer and metastases as lower values, representing restriction of water diffusion. It has been speculated that a lower ADC value reflects higher cellularity of tumors (7,17). Although the effect of T2 relaxation time, called "T2 shine-through," can cause a high signal intensity on DW images independently of restriction to water diffusion, the ADC map allowed us to consider that the high signal intensity of the tumors on the DW images reflected restriction of water diffusion, related to the high cellularity in our case (7).…”

Section: Discussionmentioning

confidence: 85%

Diffusion‐weighted magnetic resonance imaging detection of renal cancer presenting with diffuse peritoneal metastases in a patient with hemodialysis‐associated acquired cystic disease of the kidney

Kitazume

Satoh

Taura

et al. 2009

Magnetic Resonance Imaging

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A 59-year-old man was admitted with a large amount of ascites, cake-like omental thickening, and dialysis-associated acquired cystic disease of the kidney (ACDK). It was difficult to detect renal cancer, which was revealed as a primary site of peritoneal metastases by autopsy, with conventional cross-sectional imaging, such as enhanced computed tomography and T2, T1, and dynamic gadoliniumenhanced T1-weighted magnetic resonance imaging, because multiple renal cysts caused marked distortion of the renal parenchyma and the cancer had necrosis. We demonstrated the usefulness of diffusion-weighted imaging with a high b-factor to detect renal cancer presenting with peritoneal metastasis in a patient with ACDK.

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Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas

Cited by 1,046 publications

References 18 publications

Pseudoprogression, radionecrosis, inflammation or true tumor progression? challenges associated with glioblastoma response assessment in an evolving therapeutic landscape

Pseudoprogression, radionecrosis, inflammation or true tumor progression? challenges associated with glioblastoma response assessment in an evolving therapeutic landscape

Quantitative diffusion imaging in breast cancer: A clinical prospective study

Diffusion‐weighted magnetic resonance imaging detection of renal cancer presenting with diffuse peritoneal metastases in a patient with hemodialysis‐associated acquired cystic disease of the kidney

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