Usefulness of Cystatin C in the Postoperative Management of Pediatric Patients With Congenital Heart Disease

Yana, Akiko; Masutani, Satoshi; Kojima, Tetsuya; Saiki, Hiroshi; Taketazu, Mio; Tamura, Masanori; Senzaki, Hideaki

doi:10.1253/circj.cj-12-0148

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Moreover, a previous study reported that CysC itself is useful for evaluating renal function after CHD surgery. 10) The hemodynamics of patients after biventricular repair are not extremely different from those of healthy people; hence, only few studies on how cardiac function abnormalities in the remote postoperative period affect the renal function and on early evaluation of renal function have been conducted. Elevated UACR (i.e., 30 to 300 mg/gCr) is originally an early predictor of progressive renal function loss in types 1 and 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Potential Renal Dysfunction in Patients with Congenital Heart Disease after Biventricular Repair

et al. 2018

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Background and ObjectivesThere are few reports on renal dysfunction in the remote period after biventricular repair, and biomarkers for early detection of renal dysfunction are not well understood. We examined whether early fluctuation of biomarkers of renal function occurs in the remote period after biventricular repair in patients with congenital heart disease (CHD).MethodsFourteen patients with CHD after biventricular repair were included. The examination values obtained by cardiac catheterization test and renal function indices based on blood and urine sampling were compared.ResultsThe median estimated glomerular filtration rate (eGFR) of creatinine was 113 mL/min/1.73 m2, and the median eGFR of cystatin C was 117 mL/min/1.73 m2. A urine albumin-to-creatinine ratio (UACR) ≥10 mg/gCr was considered a risk factor for cardiovascular disease in 6 (43%) patients. There was a significant difference in right ventricular ejection fraction and deviation in right ventricular end-diastolic volume from the normal value between the 2 groups divided by UACR. Cyanosis before biventricular repair was noted in 2 (25%) patients with UACR <10 mg/gCr and in 4 (67%) patients with UACR ≥10 mg/gCr.ConclusionsIncreased UACR was noted in 43% of patients. In patients with UACR ≥10 mg/gCr, right heart system abnormality was observed, and several patients had cyanosis before radical treatment. Measurement for UACR may be able to detect renal dysfunction early in the postoperative remote period.

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Section: Discussionmentioning

confidence: 99%

Assessment of Potential Renal Dysfunction in Patients with Congenital Heart Disease after Biventricular Repair

et al. 2018

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Arterial Switch Operation and Plasma Biomarkers: Analysis and Correlation with Early Postoperative Outcomes

et al. 2017

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The aims of our study were to describe plasma brain natriuretic peptide (BNP), Troponin I (TnI), and Cystatin C (Cys-C) concentration kinetics in the postoperative period after arterial switch operation in neonate, and to test the correlation between the plasma biomarkers and early clinical outcomes. We prospectively enrolled 29 neonates who underwent ASO. All patients received Custodiol cardioplegia. Blood samples were collected preoperatively (one day before) and in the ICU immediately after admission, and then 6, 12, 24, and 48 h after surgery. TnI peak (mean 17.23 ± 7.0 ng/mL) occurred between the arrival in the ICU and the 6th hour, then we had a constant decrease. TnI had a good correlation with the inotropic support time (r = 0.560, p = 0.0015) and ICU time (r = 0.407, p = 0.028), less than with ventilation and Hospital stay (r = 0.37, p = 0.0451 and r = 0.385, p = 0.0404). BNP peak (mean 4773.79 ± 2724.52 ng/L) was in the preoperative time with a constant decrease after the operation and it had no significant correlations with clinical outcomes. The CyS-C had the highest preoperative values, which decreased during the operating phase, and then constantly increased upon arrival to the ICU with a peak at 48 h (mean 1.76 ± 0.35 mg/L). CyS-C peak had a good correlation with a plasmatic creatinine peak (r = 0.579, p = 0.0009) but not with other clinical outcomes. Our study demonstrated significant correlations between the Tnl peak and early clinical outcomes in neonates undergoing arterial switch operation. Other plasma biomarkers such as the BNP and CyS-C had no direct correlation.

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Utility of urinary liver-type fatty acid-binding protein as a prognostic marker in adult congenital heart patients hospitalized for acute heart failure

et al. 2022

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Usefulness of Cystatin C in the Postoperative Management of Pediatric Patients With Congenital Heart Disease

Cited by 4 publications

References 19 publications

Assessment of Potential Renal Dysfunction in Patients with Congenital Heart Disease after Biventricular Repair

Assessment of Potential Renal Dysfunction in Patients with Congenital Heart Disease after Biventricular Repair

Arterial Switch Operation and Plasma Biomarkers: Analysis and Correlation with Early Postoperative Outcomes

Utility of urinary liver-type fatty acid-binding protein as a prognostic marker in adult congenital heart patients hospitalized for acute heart failure

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