Usefulness of breast-specific gamma imaging as an adjunct modality in breast cancer patients with dense breast: a comparative study with MRI

Kim, Bom Sahn

doi:10.1007/s12149-011-0544-5

Cited by 44 publications

(29 citation statements)

References 22 publications

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“…Also, Kim included 66 patients with dense breasts and already biopsyconfirmed breast cancer. This study reported a percentage of 88.8% sensitivity and 90.1% specificity of BSGI; while MRI sensitivity and specificity were 92.3% and 39.4% respectively [17]. In the other hand, Keto, et al enrolled only 18 patients, having Ductal Carcinoma-In-Situ, who underwent both breast MRI and BSGI and found that the sensitivity for BSGI was 89% and for MRI was 94% [18].…”

Section: Resultsmentioning

confidence: 84%

Untitled

2017

Journal of Diseases

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Article HistoryBreast cancer is the most common malignant tumor among women. The objective of this research is to evaluate the specificity, sensitivity, and accuracy of BSGI, DC, and WE-MRI in the diagnosis of breast benign and malignant breast tumors. 228 female patients have participated in this observational research. The age was ranged from 31-68 years (mean age 42.37± 8.14 years) with suspicious breast lesions according to physical and imaging examination (mammography and/or ultrasonography). Moreover, women, who have suspected local regional recurrence after resection of malignant breast tumor and who were suspected to have tumor residual following chemotherapy or radiotherapy were also included. All patients underwent breast specific gamma imaging, DW-MRI, and DCE-MRI examination, and the results of breast MRI were compared with the histopathological results that were used as the standard diagnostic method. In this research, 111 women were found to have breast lesion. All breast lesions were undergone histopathological analysis using needle biopsy and/or excisional biopsy. Also, the results of the pathological analysis were correlated and confirmed with ultrasonography and mammography. The pathologic analysis confirmed that 76 (68.5%) of 111 lesions were benign breast lesions and 35 (31.5 %) of 111 were malignant breast lesions. The results proved that BSGI had the best results for the detection of breast lesions (sensitivity 96.7%, specificity 93.6 % and accuracy 94.8%) as compared with DCE-MRI (sensitivity 92.3%, specificity 85.6% and accuracy 88.2%) and diffusion weighted imaging (sensitivity 94.1%, specificity 88.5% and accuracy 91.4%). The research stated that BSGI is the most appropriate diagnostic tool for breast lesions.Contribution/Originality: This study documents that Breast Specific Gamma Imaging (BSGI) is the most suitable diagnostic tool for benign and malignant breast tumors. Specifically, the study has contributed in identifying the specificity, sensitivity, and accuracy of BSGI in the diagnosis of breast lesions and tumors.

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Section: Resultsmentioning

confidence: 84%

Untitled

2017

Journal of Diseases

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“…6,121,122 In a comparison of BSGI with MRI used in preoperative evaluation, the sensitivities of the two techniques were similar (89% and 92%) but BSGI demonstrated significantly better specificity of 90% compared to 39% for MRI (p < 0.0001). 123 A study performed using a dedicated CZT-based MBI system and 99m Tc-tetrofosmin in 264 patients showed gamma imaging to significantly improve detection of multifocal or multicentric disease compared to that detected with mammography (88% vs 48% of cases, p < 0.0005) and to correctly alter surgical management in 16% of patients. 124 Preliminary results from a similar study using a dual-head version of the CZT-based MBI system and reduced doses of ∼300 MBq 99m Tc-sestamibi were reported: gamma imaging detected additional disease not appreciated by mammography and ultrasound in 12 of 98 patients (12%), which altered surgical management.…”

Section: Ivb Preoperative Evaluationmentioning

confidence: 99%

Nuclear imaging of the breast: Translating achievements in instrumentation into clinical use

Hruska

O’Connor

2013

Medical Physics

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Approaches to imaging the breast with nuclear medicine and/or molecular imaging methods have been under investigation since the late 1980s when a technique called scintimammography was first introduced. This review charts the progress of nuclear imaging of the breast over the last 20 years, covering the development of newer techniques such as breast specific gamma imaging, molecular breast imaging, and positron emission mammography. Key issues critical to the adoption of these technologies in the clinical environment are discussed, including the current status of clinical studies, the efforts at reducing the radiation dose from procedures associated with these technologies, and the relevant radiopharmaceuticals that are available or under development. The necessary steps required to move these technologies from bench to bedside are also discussed.

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“…Several studies have demonstrated that BSGI and DEC-MRI have similar sensitivity and specificity in breast cancer detection (12,13). However, little is known about the correlation of 99mTc-MIBI uptake in BSGI with DCE-MRI parameters of breast cancer.…”

Section: Mri Is An Effective Diagnostic Tool For Differentiation Betweenmentioning

confidence: 99%

Correlation of Semi-Quantitative Breast-Specific Gamma Imaging Findings with Dynamic Contrast-Enhanced MRI Parameters Assessed by a Computer-Aided Evaluation Program for Breast Cancer

Ahn

Koo

Park

et al. 2018

J Korean Soc Radiol

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Purpose: To investigate whether a correlation exists between the semi-quantitative breast-specific gamma imaging (BSGI) findings and dynamic contrast-enhanced (DCE) MRI parameters assessed by a computer-aided evaluation program. Materials and Methods: Semi-quantitative index of the lesion to non-lesion (L/N) ratio in BSGI and DCE-MRI parameters was assessed by a computer-aided evaluation program, where 47 cases of invasive breast cancer were obtained. Correlations between the L/N ratio and DCE-MRI parameters were assessed by a computer-aided evaluation program. Tumor diameter (cm), angio-volume (cc), degree of initial peak enhancement (%), persistent enhancement proportion (%), and washout enhancement proportion (%) were analysed. The relationships between the L/N ratio and DCE-MRI parameters were evaluated by a univariate and multivariate regression analysis. Results: The mean L/N ratio of the 47 tumors was 3.63 ± 2.19 (range: 1-13.1). The L/N ratio was higher in tumors with larger diameters (p < 0.001), increased angiovolume (p < 0.001), higher degree of initial peak enhancement (p = 0.005) and increased washout enhancement proportion (p = 0.004). In the multivariate regression analysis, angio-volume (cc) and washout enhancement proportion (%) were associated with L/N ratio (p = 0.007 and p = 0.024, respectively). Conclusion: There was a correlation between the semi-quantitative L/N ratio in BSGI and DCE-MRI parameters assessed by a computer-aided evaluation program for breast cancer.

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Usefulness of breast-specific gamma imaging as an adjunct modality in breast cancer patients with dense breast: a comparative study with MRI

Cited by 44 publications

References 22 publications

Untitled

Untitled

Nuclear imaging of the breast: Translating achievements in instrumentation into clinical use

Correlation of Semi-Quantitative Breast-Specific Gamma Imaging Findings with Dynamic Contrast-Enhanced MRI Parameters Assessed by a Computer-Aided Evaluation Program for Breast Cancer

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