Usefulness of Bacterial Culture of Drainage Fluid for Predicting Surgical Site Infection After Crohn’s Disease Surgery

Ichihara, Momoko; Ogino, Takayuki; Fujii, Makoto; Haraguchi, Naotsugu; Takahashi, Hidekazu; Miyoshi, Norikatsu; Uemura, Mamoru; Doki, Yuichiro; Eguchi, Hidetoshi; Mizushima, Tsunekazu

doi:10.1002/ags3.12530

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…A rapid increase in the incidence of IBD, which is broadly divided into Crohn’s disease (CD) and ulcerative colitis (UC), has been observed in Asia owing to the westernization of diet and lifestyle ( 14 ). IBD is an intractable disease in which inflammation in intestinal tissue recurs chronically ( 15 , 16 ); however, many aspects of its detailed pathogenic mechanism remain unclear. The adaptive immune system, including Th1/Th2 imbalance and excessive Th17-induced immunity, has been the focus of discussion in the pathology of IBD.…”

Section: Introductionmentioning

confidence: 99%

Immunoregulation by antigen-presenting cells in human intestinal lamina propria

Ogino

Takeda

2023

Front. Immunol.

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Antigen-presenting cells, including macrophages and dendritic cells, are a type of innate immune cells that can induce the differentiation of T cells and activate the adaptive immune response. In recent years, diverse subsets of macrophages and dendritic cells have been identified in the intestinal lamina propria of mice and humans. These subsets contribute to the maintenance of intestinal tissue homeostasis by regulating the adaptive immune system and epithelial barrier function through interaction with intestinal bacteria. Further investigation of the roles of antigen-presenting cells localized in the intestinal tract may lead to the elucidation of inflammatory bowel disease pathology and the development of novel treatment approaches.

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