Use Patterns and Perceptions of Non-Traditional Therapies in Radiotherapy Patients: Results from the Multi-Institutional Complementary and Alternative Medicine Exposure in Oncology (CAMEO) Study

Weil, Christopher R.; Hutten, R.; Barney, B.M.; Fagerlin, A.S.; Gaffney, D.K.; Gill, D.; Whipple, G.L.; Rhodes, T.; Scherer, L.; Suneja, G.; Tward, J.D.; Werner, T.; Evans, J.D.; Johnson, S.B.

doi:10.1016/j.ijrobp.2022.07.1677

International Journal of Radiation Oncology*Biology*Physics

2022

DOI: 10.1016/j.ijrobp.2022.07.1677

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Use Patterns and Perceptions of Non-Traditional Therapies in Radiotherapy Patients: Results from the Multi-Institutional Complementary and Alternative Medicine Exposure in Oncology (CAMEO) Study

Christopher R. Weil

R. Hutten²,

B.M. Barney³

et al.

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2023

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“…Phytoestrogen consumption and phytotherapy (herbal medicine, botanical medicine) use are prevalent following a breast cancer diagnosis ( 1-3 ) for reasons that include preventing recurrence or metastasis and prolonging life ( 4 , 5 ). Exposure to phytonutrients (bioactive phytochemicals, or plant-derived compounds) and their sources may be through established dietary habits before diagnosis, dietary modification, or phytotherapeutic supplements following diagnosis.…”

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Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies

van Die,

Bone,

Visvanathan

et al. 2023

JNCI Cancer Spectrum

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Background Phytonutrient intakes may improve outcomes following breast cancer, but the impact of post-diagnosis introduction vs established pre-diagnostic exposure, and optimum doses, have not been established. Evidence from observational studies for key exposures was evaluated, including dosage and intake timeframes. Methods MEDLINE, EMBASE, CINAHL, Cochrane Library, ClinicalTrials.gov, ISRCTN registry and ICMJE were searched for prospective and retrospective observational studies investigating soybean, lignans, cruciferous/cabbage-family vegetables, green tea, or their phytonutrients, and breast cancer survival outcomes. A random effects model was used to calculate summary hazard ratios (HRs) and 95% confidence intervals. Nonlinear dose-response analyses were conducted using restricted cubic splines. Results Thirty-two articles were included. Soy isoflavones were associated with a 26% reduced risk of recurrence [HR 0.74 (0.60–0.92)], particularly among post-menopausal [HR 0.72 (0.55–0.94)] and estrogen-receptor (ER)+ survivors [HR 0.82 (0.70–0.97), with the greatest risk reduction at 60 mg/day. In mortality outcomes, the reduction was mostly at 20-40 mg/d. Soy protein/products were inversely associated with cancer-specific mortality for ER+ disease [HR 0.75 (0.60–0.92)]. An inverse association was observed for serum/plasma enterolactone, measured pre-diagnosis and early post-diagnosis, with cancer-specific mortality [HR 0.72 (0.58–0.90)], and all-cause mortality [HR 0.69 (0.57–0.83]. No effects were observed for cruciferous vegetables. There was a 44% reduced risk of recurrence with pre-diagnostic green tea for stages I-II breast cancer [HR 0.56 (0.38–0.83)]. Conclusions Soy, enterolactone and green tea demonstrated significant risk reductions in outcomes following breast cancer. Evidence is needed regarding the impact of post-diagnostic introduction or substantial increase of these exposures.

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mentioning

confidence: 99%

Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies

van Die,

Bone,

Visvanathan

et al. 2023

JNCI Cancer Spectrum

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Use Patterns and Perceptions of Non-Traditional Therapies in Radiotherapy Patients: Results from the Multi-Institutional Complementary and Alternative Medicine Exposure in Oncology (CAMEO) Study

Cited by 1 publication

References 0 publications

Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies

Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies

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