Use of transcolonic portal scintigraphy to evaluate efficacy of cellophane banding of congenital extrahepatic portosystemic shunts in 16 dogs

Landon, BP; Abraham, LA; Charles, JA

doi:10.1111/j.1751-0813.2008.00278.x

Cited by 50 publications

(108 citation statements)

References 26 publications

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“…Ongoing studies to determine additional prognostic factors for surgical outcomes are expected to identify such prognostic tests in coming years. 5,[23][24][25][26][27][28] Presently, protein restriction without much emphasis on the source and quality of the protein often is used. The most stringent protein restriction is provided by renal diets, but several liver support diets also are available.…”

Section: Discussionmentioning

confidence: 99%

Soy Protein Isolate versus Meat‐Based Low‐Protein Diet for Dogs with Congenital Portosystemic Shunts

Proot

Biourge

Teske

et al. 2009

Veterinary Internal Medicne

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Background: Both presurgical preparation and long-term support of nonoperable dogs with congenital portosystemic shunts (CPSS) require optimal dietary management. Studies suggested that protein source may play an important role, with vegetable and dairy protein sources having better effects on hepatic encephalopathy (HE) than meat proteins.Objectives: Determine whether a low-protein test diet with soy as its main protein source results in better scores than a control diet with the same composition but with poultry as its main protein source in dogs with CPSS.Methods: In a double-blind cross-over study, 16 dogs received each diet for 4 weeks. Dogs in group T first received the test diet and then the control diet, whereas dogs in group C were fed the diets in the opposite order. Different variables (body weight, body condition score, HE score, fecal score, CBC, plasma tests of liver function including NH 3 , and coagulation tests) were measured at the start of the study and after completion of each diet.Results: One-way repeated measures ANOVA was performed. Plasma NH 3 was significantly lower after the test diet than after the control diet. The test diet also resulted in significantly higher fibrinogen concentrations and lower prothrombin times. The HE score improved with both diets, with no significant difference between the 2 diets.Conclusions: Both diets achieved a significant improvement in HE score. The influence of the soy-based diet on plasma NH 3 concentration and coagulation parameters suggests that such a diet decreases the risk for HE and gives better support of liver function.

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Section: Discussionmentioning

confidence: 99%

Soy Protein Isolate versus Meat‐Based Low‐Protein Diet for Dogs with Congenital Portosystemic Shunts

Proot

Biourge

Teske

et al. 2009

Veterinary Internal Medicne

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show abstract

“…13,24,31 Hepatic regeneration as evidenced by an increase in liver volume and return of biochemical parameters to normal occurs in many dogs following attenuation of a CPS, or administration of hepatocyte growth factor. 9,14,15,28,29 However, in some patients liver function never returns to normal, and portal hypertension results in development of multiple acquired shunts, 9,16,20,21 leading to speculation that the liver’s ability to respond to normal trophic factors is impaired.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hepatic Steatosis in Dogs With Congenital Portosystemic Shunts Using Oil Red O Staining

et al. 2013

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The aims of this prospective study were to quantify steatosis in dogs with congenital portosystemic shunts using a fat-specific stain, to compare the amount of steatosis in different lobes of the liver, and to evaluate intra- and inter-Observer variability in lipid point counting. Computer-assisted point counting of lipid droplets was undertaken following Oil-Red-O staining in 21 dogs with congenital portosystemic shunts and 9 control dogs. Dogs with congenital portosystemic shunts had significantly more small lipid droplets (< 6 μ) than control dogs (p = 0.0013 and 0.0002, respectively). There was no significant difference in steatosis between liver lobes for either control dogs and CPS dogs. Significant differences were seen between observers for the number of large lipid droplets (> 9 μ) and lipogranulomas per tissue point (p = 0.023 and 0.01, respectively). In conclusion, computer-assisted counting of lipid droplets following Oil Red O staining of liver biopsy samples allows objective measurement and detection of significant differences between dogs with CPS and normal dogs. This method will allow future evaluation of the relationship between different presentations of CPS (anatomy, age, breed) and lipidosis, as well as the impact of hepatic lipidosis on outcomes following surgical shunt attenuation.

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“…For example, a high shunt fraction remained evident in 6 of 16 dogs with naturally occuring portosystemic shunts 10 weeks after band placement in 1 study, 14 with shunt closure achieved within 10 weeks in 10 of 16 dogs. For example, a high shunt fraction remained evident in 6 of 16 dogs with naturally occuring portosystemic shunts 10 weeks after band placement in 1 study, 14 with shunt closure achieved within 10 weeks in 10 of 16 dogs.…”

Section: Discussionmentioning

confidence: 94%

“…7,8 Additionally, the inconsistency in material composition that exists with compounds such as cellophane leads to differences in handling and potential variability in closure periods in vivo, as different materials may elicit a more or less robust foreign body reaction. 14,15 Few studies have involved use of scintigraphy or angiography to determine the period required to achieve occlusion with cellophane banding, and most available information is based on serial bile acid or ammonia concentrations. 6,[10][11][12] The optimal period during which surgical closure of a portosystemic shunt should be achieved is unknown.…”

mentioning

confidence: 99%

In vitro development and evaluation of a polyacrylic acid–silicone device intended for gradual occlusion of portosystemic shunts in dogs and cats

Wallace¹,

Ellison²,

Batich³

et al. 2016

ajvr

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Use of transcolonic portal scintigraphy to evaluate efficacy of cellophane banding of congenital extrahepatic portosystemic shunts in 16 dogs

Cited by 50 publications

References 26 publications

Soy Protein Isolate versus Meat‐Based Low‐Protein Diet for Dogs with Congenital Portosystemic Shunts

Soy Protein Isolate versus Meat‐Based Low‐Protein Diet for Dogs with Congenital Portosystemic Shunts

Evaluation of Hepatic Steatosis in Dogs With Congenital Portosystemic Shunts Using Oil Red O Staining

In vitro development and evaluation of a polyacrylic acid–silicone device intended for gradual occlusion of portosystemic shunts in dogs and cats

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