Use of the Rey-Osterrieth Complex Figure Test for neurotoxicity evaluation of mixtures in children

Rocha-Amador, Diana Olivia; Navarro, María Elena; Trejo-Acevedo, Antonio; Carrizales, Leticia; Pérez-Maldonado, Iván N.; Dı́az-Barriga, Fernando; Calderón, Jaqueline

doi:10.1016/j.neuro.2009.09.003

Cited by 23 publications

(4 citation statements)

References 36 publications

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“…These tests include the Developmental Test of Visual-Motor Integration (15–17), the Rey-Osterrieth Complex Figure Test (18)and the Bender-Gestalt test (19), . Winneke (1996) suggested that visual-motor integration is more consistently associated with increased lead exposure than is psychometric intelligence (20).…”

Section: Discussionmentioning

confidence: 99%

Lead exposure and visual-motor abilities in children from Chennai, India

et al. 2011

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Lead exposure poses a major environmental hazard in India, but little information is available on the impact of lead exposure on neurobehavioral development in Indian children. We hypothesize that higher blood lead levels are associated with poorer visual-motor, visual-spatial and fine motor functioning among children. We conducted a cross-sectional study of 814 school children, aged 3–7 years. Lead in whole blood was measured using the LeadCare Analyzer. The Wide Range of Visual Motor Abilities Test (WRAVMA) was administered to each child by trained examiners. The mean blood lead level was 11.4 ± 5.3 μg//dL. In multivariate analyses adjusting for mother’s education level, fathers education level, average monthly income, hemoglobin and sex, WRAVMA scores were inversely related to blood lead level. An increase of 10 μg/dL was associated with a decrease of 2.6 points (95% CI: −4.5 to −0.7, P=0.006) in the Visual Motor Composite score and a decrease of 2.9 points (95% CI: −5.1 to −0.7, P=0.011) in the Drawing subtest. Exploration of the shape of the dose-effect relationships using spline functions indicated some non-linearities, with the steepest declines in visual-motor skills occurring at higher blood lead levels. Among urban Indian children, higher blood lead levels are associated with decreased visual-motor abilities, particularly visual-motor integration.

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Section: Discussionmentioning

confidence: 99%

Lead exposure and visual-motor abilities in children from Chennai, India

et al. 2011

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“…There are many risks associated with arsenic exposure including genotoxicity and neurotoxicity [Rocha‐Amador et al, ; Tyler and Allan, ; Jasso‐Pineda et al, ]. Exposure to this metalloid also represents a risk for metabolic disorders [Osorio‐Yáñez et al, and ; Mendez et al, ], respiratory damage [Olivas‐Calderón et al, ; Recio‐Vega et al, ] and diabetes [Del Razo et al, ; Drobná et al, ] at exposure levels comparable to those used in the present study.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí

Alegría-Torres

Carrizales-Yáñez

Dı́az-Barriga

et al. 2016

Environ and Mol Mutagen

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Arsenic is a carcinogen and epimutagen that threatens the health of exposed populations worldwide. In this study, we examined the methylation status of Alu and long interspersed nucleotide elements (LINE-1) and their association with levels of urinary arsenic in 84 Mexican children between 6 and 12 years old from two historic mining areas in the State of San Luis Potosí, Mexico. Urinary arsenic levels were determined by atomic absorption spectrophotometry and DNA methylation analysis was performed in peripheral blood leukocytes by bisulfite-pyrosequencing. The geometric mean of urinary arsenic was 26.44 µg/g Cr (range 1.93-139.35). No significant differences in urinary arsenic or methylation patterns due to gender were observed. A positive correlation was found between urinary arsenic and the mean percentage of methylated cytosines in Alu sequences (Spearman correlation coefficient r = 0.532, P < 0.001), and a trend of LINE-1 hypomethylation was also observed (Spearman correlation coefficient r = -0.232, P = 0.038) after adjustment for sex and age. A linear regression model showed an association with log-normalized urinary arsenic for Alu (β = 1.05, 95% CI: 0.67; 1.43, P < 0.001) and LINE-1 (β = -0.703, 95% CI: -1.36; -0.38, P = 0.038). Despite the low-level arsenic exposure, a subtle epigenetic imbalance measured as DNA methylation was detected in the leukocytes of Mexican children living in two historic mining areas. Environ. Mol. Mutagen. 57:717-723, 2016. © 2016 Wiley Periodicals, Inc.

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“…Importantly, among children who were exposed environmentally to water fluoridated at 1.2 - 3 mg/L (slightly above the U.S. recommended level), increased urinary fluoride concentrations were associated with slower reaction time and poorer visuospatial organization that could interfere with attention, and reading and writing respectively [ 47 ]. Additionally, urinary fluoride of 5.6 ± 1.7 mg/L was inversely related to performance on a measure of visual memory and visuospatial organization, as well as attention (the Rey-Osterrieth Complex Figure Test) [ 48 ]. A recent meta-analysis, which included a number of epidemiological studies, also found that children living in ‘high fluoride’ areas had IQs that averaged 7 points lower than those living in ‘low fluoride’ areas [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association

Malin

Till

2015

Environ Health

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BackgroundEpidemiological and animal-based studies have suggested that prenatal and postnatal fluoride exposure has adverse effects on neurodevelopment. The aim of this study was to examine the relationship between exposure to fluoridated water and Attention-Deficit Hyperactivity Disorder (ADHD) prevalence among children and adolescents in the United States.MethodsData on ADHD prevalence among 4-17 year olds collected in 2003, 2007 and 2011 as part of the National Survey of Children’s Health, and state water fluoridation prevalence from the Centers for Disease Control and Prevention (CDC) collected between 1992 and 2008 were utilized.ResultsState prevalence of artificial water fluoridation in 1992 significantly positively predicted state prevalence of ADHD in 2003, 2007 and 2011, even after controlling for socioeconomic status. A multivariate regression analysis showed that after socioeconomic status was controlled each 1% increase in artificial fluoridation prevalence in 1992 was associated with approximately 67,000 to 131,000 additional ADHD diagnoses from 2003 to 2011. Overall state water fluoridation prevalence (not distinguishing between fluoridation types) was also significantly positively correlated with state prevalence of ADHD for all but one year examined.ConclusionsParents reported higher rates of medically-diagnosed ADHD in their children in states in which a greater proportion of people receive fluoridated water from public water supplies. The relationship between fluoride exposure and ADHD warrants future study.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-015-0003-1) contains supplementary material, which is available to authorized users.

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Use of the Rey-Osterrieth Complex Figure Test for neurotoxicity evaluation of mixtures in children

Cited by 23 publications

References 36 publications

Lead exposure and visual-motor abilities in children from Chennai, India

Lead exposure and visual-motor abilities in children from Chennai, India

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí

Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association

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