Use of Sulfanilamide and Its Derivatives in Ointment Form

Lowered Incidence of Sensitization with Sulphonamide Combinations

“…62 In fact, Lowell71 recently stated that " allergic reactions were so frequent and severe in eczematous areas of the skin that the prolonged use of sulphonamides on such sites has been cautioned against repeatedly." Systemic readministration of a sulphonamide to patients sensitized locally by previous topical application will often show exclusive or predominant reaction at the locally sensitized area.70 [72][73][74][75][76][77][78][79][80] Finally, the dependence of sensitization on absorbability and tissue concentration of sulphonamides can also be inferred from the excellent and exacting study of Sulzberger and associates62 on human volunteers. These authors investigated the " incidence of dermatitis following treatment with measured amounts of different sulphonamides in the same vehicle, on standard lesions (third-degree burns), in men of the same age group, living in the same environment, on the same diets, at the same occupation, and under similar experimental conditions."…”

Solubility and Thermodynamic Modeling of Sulfanilamide in 12 Mono Solvents and 4 Binary Solvent Mixtures from 278.15 to 318.15 K

“…63-74-1, C 6 H 8 N 2 O 2 S, 172.202 g mol –1 ), IUPAC name is 4-aminobenzenesulfonamide, is an organic sulfur compound structurally similar to p -aminobenzoic acid and has antibacterial properties. ,, Therefore, sulfanilamide is basically used as an antibiotic to treat infections caused by some fungi and protozoa microorganisms. Furthermore, its derivatives are now used in the diagnosis and treatment of human brucellosis and steadily evolving dermatoses. , The solubility of sulfanilamide in different solvents and at different temperatures is an important parameter in the pharmaceutical industry to achieve desired formulation and dosage . Hence, suitable solvent selection is the most challenging factor to avoid bacterial contamination and increase the solubility of the solute …”

“…Furthermore, its derivatives are now used in the diagnosis and treatment of human brucellosis and steadily evolving dermatoses. 8,9 The solubility of sulfanilamide in different solvents and at different temperatures is an important parameter in the pharmaceutical industry to achieve desired formulation and dosage. 3 Hence, suitable solvent selection is the most challenging factor to avoid bacterial contamination and increase the solubility of the solute.…”