Use of small scale bioassays in the discovery of novel drugs from natural sources

Chemical composition of the essential oil of Viola serpens from Bageshwar (Shama), Uttarakhad, India

“…The compounds from the plant based essential oil are useful as an alternative therapy, either directly or as models for new synthetic products (Houghton, 2000). Aromatherapy is the therapeutic use of fragrances or at least mere volatiles to cure diseases, infections and indispositions by means of inhalation (Buchbauer, 2000;Buchbauer et al, 1993).…”

Chemical composition of the essential oil of Viola serpens from Bageshwar (Shama), Uttarakhad, India

“…The compounds from the plant based essential oil are useful as an alternative therapy, either directly or as models for new synthetic products (Houghton, 2000). Aromatherapy is the therapeutic use of fragrances or at least mere volatiles to cure diseases, infections and indispositions by means of inhalation (Buchbauer, 2000;Buchbauer et al, 1993).…”

Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India

“…This is partly due to the ethical and commercial problems of using animals but also the unsuitability of such practices for bioassay-guided fractionation of the compounds responsible for any activity observed (Houghton, 2000). In spite of the widespread use of in vitro assays, it is important to point out the deficiencies of such an approach.…”

Enhancement of cognitive performance in mice and in vitro acetyl-cholinesterase inhibitory activity of 3,3’,4’,5,7-pentahydroxyflavone isolated from <i>Cadaba indica</i>

“…Combining bioassay and fractionation had fastened the procedure to identify the active compound in the ethanol extract of C. indica. This bioactive fraction was further reconstituted with appropriate solvent after lyophilization and the active compound was characterized using IR, UV, NMR spectroscopy and mass chromatographic analytical procedures (Houghton, 2000).…”

Chemical composition of the essential oil of Viola serpens from Bageshwar (Shama), Uttarakhad, India

“…The compounds from the plant based essential oil are useful as an alternative therapy, either directly or as models for new synthetic products (Houghton, 2000). Aromatherapy is the therapeutic use of fragrances or at least mere volatiles to cure diseases, infections and indispositions by means of inhalation (Buchbauer, 2000;Buchbauer et al, 1993).…”

Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India

“…This is partly due to the ethical and commercial problems of using animals but also the unsuitability of such practices for bioassay-guided fractionation of the compounds responsible for any activity observed (Houghton, 2000). In spite of the widespread use of in vitro assays, it is important to point out the deficiencies of such an approach.…”

Enhancement of cognitive performance in mice and in vitro acetyl-cholinesterase inhibitory activity of 3,3’,4’,5,7-pentahydroxyflavone isolated from <i>Cadaba indica</i>

“…Combining bioassay and fractionation had fastened the procedure to identify the active compound in the ethanol extract of C. indica. This bioactive fraction was further reconstituted with appropriate solvent after lyophilization and the active compound was characterized using IR, UV, NMR spectroscopy and mass chromatographic analytical procedures (Houghton, 2000).…”

Chemical composition of the essential oil of Viola serpens from Bageshwar (Shama), Uttarakhad, India

“…The compounds from the plant based essential oil are useful as an alternative therapy, either directly or as models for new synthetic products (Houghton, 2000). Aromatherapy is the therapeutic use of fragrances or at least mere volatiles to cure diseases, infections and indispositions by means of inhalation (Buchbauer, 2000;Buchbauer et al, 1993).…”

Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India

“…This is partly due to the ethical and commercial problems of using animals but also the unsuitability of such practices for bioassay-guided fractionation of the compounds responsible for any activity observed (Houghton, 2000). In spite of the widespread use of in vitro assays, it is important to point out the deficiencies of such an approach.…”

Enhancement of cognitive performance in mice and in vitro acetyl-cholinesterase inhibitory activity of 3,3’,4’,5,7-pentahydroxyflavone isolated from <i>Cadaba indica</i>

“…Combining bioassay and fractionation had fastened the procedure to identify the active compound in the ethanol extract of C. indica. This bioactive fraction was further reconstituted with appropriate solvent after lyophilization and the active compound was characterized using IR, UV, NMR spectroscopy and mass chromatographic analytical procedures (Houghton, 2000).…”