Use of Shenhuang paste on Shenque point improves chemotherapy induced gastrointestinal toxicity in breast cancer

Abstract

Background: Breast cancer, a malignant disorder, occurs in the epithelial tissue of the breast gland. Chemotherapy is the standard treatment for breast cancer, however, the side effect, especially gastrointestinal dysfunction, due to chemotherapy still remain major problems. Traditional Chinese Medicine has been proven therapeutically effective on reducing adverse effects caused by chemotherapy. Shenhuang Plaster Methods: The study is a randomized, placebo-controlled, blind trial. A total of 160 Chinese breast cancer patients will be enrolled and randomly allocated into the experimental group and control group in a 1:1 ratio. Patients in the experimental group will be prescribed Shenhuang plaster application on shenque point (CV8) plus chemotherapy treatment. Patients in the control group will be prescribed placebo plaster application on CV8 plus chemotherapy treatment. The acupoint application will last 3 days. The primary outcome will be the form of faces every day, and the secondary outcomes the symptom score of traditional Chinese medicine, the changes of fecal bacteria and metabolites, serum motilin, gastrin and ghrelin levels. Discussion: This study is to observe therapeutic effects with Shenhuang plaster application on CV8 to regulate chemotherapy-induced gastrointestinal toxicity in breast cancer patients. Trial registration: Chinese Clinical Trial Registry ( http://www.chictr.org.cn/showproj.aspx?proj=55262 ) No. ChiCTR2000034313. Registered on July 2, 2020.

Combination of BFHY with Cisplatin Relieved Chemotherapy Toxicity and Altered Gut Microbiota in Mice

“…Acupuncture is an important complementary therapy used in cancer treatment, Xu et al found that acupuncture treatment can inhibit the development of osteosarcoma by regulating intestinal microbiome [30]. What's more, in a randomized, placebo-controlled, blind trial, Wang et al observed that Shenhuang plaster application could relieve chemotherapy-induced gastrointestinal toxicity in breast cancer patients [31]. Additionally, gut microbiota promotes the maintaining of health and acts as adjuvants in the treatment of cancer [32].…”

Are Published Cancer Care Trial Protocols With Traditional Chinese Medicine Interventions Concordant With SPIRIT-TCM Extension 2018? A Scoping Review on Published Trial Protocols Between 2019 and 2022

“…The scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. 20 …”

“…The overall concordance rate was very low, notably in reporting the formula’s profile in safety and quality. There was very low concordance at 5% (1/22) with reporting the formula’s safety assessment, 37 9% (2/22) with reporting the quality control of each ingredient and the formula as a whole, 20 , 37 0% (0/22) with reporting the production method of the formula, and 5% (1/22) with reporting the authentication method of each ingredient. 37 There was very low concordance with reporting the formula’s details of administration such as dosage at 5% (1/22), fair concordance with reporting administration route at 50% (11/22), low concordance with reporting dosage form at 23% (5/22), and low concordance with reporting substance name 36% (8/22).…”

Studies on the Mechanism of the Volatile Oils from Caoguo-4 Decoction in Regulating Spleen Deficiency Diarrhea by Adjusting Intestinal Microbiota

“…Therefore, a better understanding of the gastrointestinal microflora in SDD has been of great significance. Acupoint application therapy is the application of Chinese herbal medicine to the corresponding points to regulate meridians, yin and yang, and qi as well as the blood of the human body [ 8 ]. The Shenque point has a thin cuticle making it conducive to rapid drug absorption, and its location close to the intestinal tract strengthens the spleen and stomach by promoting the flow of Qi and relaxing the bowels [ 9 ].…”