Use of renal risk drugs in hospitalized patients with impaired renal function--an underestimated problem?

Abstract

Among patients admitted to general hospitals, a considerable proportion had renal impairment. In patients with reduced renal function, renal risk drugs were widely used and often in combination. DRPs were frequently associated with the use of renal risk drugs.

Inappropriate use of nonsteroidal anti-inflammatory drugs and other drugs in chronic kidney disease patients without renal replacement therapy

“…In patients with kidney insufficiency, as the frequency of inappropriate drug use increases, the course of disease worsens. 8 Inappropriate drug use results in a 40% increase in the mortality of the patients with insufficient renal function. 17 The present study has revealed that inappropriate drug use is quite common in the CKD population.…”

“…The rate of inappropriate drug use found in this study is higher compared to the findings of other studies. 8,12,16,21,22 The negative effects of nonsteroid anti-inflammatory drugs on renal functions have been known. In our study, 44.3% of CKD patients were aged 65 and over, and the rate of inappropriate drug use was higher in this group compared to the rest of the population (86.6% vs. 75.7%).…”

“…13,17,23,32 Taking inappropriate drug use into consideration will certainly help clinicians and other health professionals decrease side effects and complications. 8 In summary, inappropriate drug use, nonoptimal dosing, drug interaction and side effects entail particular attention. We think that, in order to assure renal protection, health professionals need to examine renal functions and calculate GFR values of a patient to avoid inappropriate drug use.…”

“…[4][5][6] When CKD is not diagnosed or is treated inappropriately, the chance to prevent progression may be missed. 7,8 Many drugs and their metabolites are excreted by kidneys. That is why inappropriate drug use in patients with CKD may cause adverse effects on patients and progression of chronic renal failure.…”

“…That is why inappropriate drug use in patients with CKD may cause adverse effects on patients and progression of chronic renal failure. [8][9][10][11] Conservative therapy is also used for treatment and prevention of progression of the disease. One of the most important factors influencing the success of conservative therapy is detecting and eliminating predisposing factors.…”