Use of proton pump inhibitors correlates with increased risk of colorectal cancer in <scp>T</scp>aiwan

Lai, Shih Wei; Liao, Kuan Fu; Lai, Hsueh Chou; Lin, Cheng Li; Sung, Fung Chang

doi:10.1111/ajco.12054

Cited by 34 publications

(75 citation statements)

References 5 publications

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“…• The infections, particularly, the bacterial pneumopathies [24] and the intestinal infections, especially to Clostridium difficilae [25] • Osteoporotic fractures [26,27] • On the other hand, medicines decreasing the acid gastric secretion such as the long-term PPI would be theoretically capable of leading the genesis of gastric tumors, and even colorectal; in fact, the hypergastrinemia is led by these treatments [28,29].…”

Section: Discussionmentioning

confidence: 99%

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Boudabous¹,

Gdoura²,

Mnif³

et al. 2017

Esophageal Abnormalities

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The proton-pump inhibitor (PPI) is an effective and widely used treatment but may cause side effects, especially for the elderly. Materials and methods: this is a cross-sectional study including 45 patients older than 65 years, followed at our outpatient and treated with PPIs for at least a year. The indication for PPI, the results of any endoscopy, and the quality of the tolerance of these molecules is specified by the data folder. During the consultation, we conducted an interrogation to an update of the history and medications to our patients and a type checking of the molecule, the dose, and the quality of the observance. Results: patients were divided into 32 women and 13 men with a mean age of 75 ± 7 years (65-92). The average length of PPI use was 6 ± 4 years (1-16) with a consumption of a double dose for at least 1 year in 28.8% of cases. The prescribed dose was higher than the recommended dose in at least 15.5% of cases. PPIs were well tolerated. One patient had presented a microscopic colitis, revealed by diarrhea regressed after discontinuation of PPIs. Conclusion: PPIs were prescribed in elderly subjects by gastroenterologists, in a university center, with a high dose and long. In our series, this treatment is well tolerated in the elderly.

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Section: Discussionmentioning

confidence: 99%

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Boudabous¹,

Gdoura²,

Mnif³

et al. 2017

Esophageal Abnormalities

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“…Specifically, in the patients who were taking a ppi at the time of diagnosis, we observed a trend toward a decreased 1-, 2-, and 5-year os, as well as a statistically significant decrease in cumulative os. Earlier studies looking at ppi use and crc have looked only for correlations between ppi use and the risk of developing crc [13][14][15][16] . The present study is the first to look specifically at a potential relationship between ppis and os in crc patients.…”

Section: Discussionmentioning

confidence: 99%

“…Case-control studies have produced inconsistent, conflicting results about the relationship between ppi use and crc risk. In a small number of studies, a weak-to-moderate association was identified between ppi use and crc risk; others have found that the use of ppis might not in fact be associated with an increased risk of developing crc [13][14][15][16] . Overall, studies that have examined the relationship between ppi use and crc have been significantly limited by small sample sizes.…”

Section: Introductionmentioning

confidence: 97%

A Retrospective Analysis of the Role of Proton Pump Inhibitors in Colorectal Cancer Disease Survival

et al. 2016

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“…However, consensus remains elusive. For example, a study in UK found that long‐term PPI therapy at a regular dose was not associated with colorectal cancer41; however, another study in Taiwan found that PPI use had a 2.5‐fold association risk of colorectal cancer 42. Authors of the Taiwan study concluded that patients with occult colorectal cancer had longstanding reflux or upper gastrointestinal symptoms and concomitantly received PPI treatment.…”

Section: Discussionmentioning

confidence: 99%

Proton pump inhibitors and risk of periampullary cancers—A nested case–control study

Chien

Huang

Shao

et al. 2015

Intl Journal of Cancer

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Considerable attention has been focused on long‐term use of proton pump inhibitor (PPI) medications in relation to increased risk of cancer via stimulation of DNA‐damaged cells. The aim of this study is to examine the dose‐dependent effect of PPI on periampullary cancers in a national population‐based cohort. A nested case–control analysis was constructed based on Taiwan's National Health Insurance Research Database and the Taiwan Cancer Registry between the years 2000 and 2010. Cases involving patients diagnosed with periampullary cancers were selected and controls were matched to cases according to age, sex and observational period. A “PPI user” was defined as any patient receiving more than 28 cumulative defined daily doses as measured by prescription drug claims. Conditional logistic regression analysis was conducted to calculate odds ratios (ORs) and 95% confidence intervals (CIs) according to the level of PPI exposure. A total of 7,681 cases and 76,762 matched controls were included with a mean follow‐up period of 6.6 years (SD: 2.0). The odds of PPI exposure in patients with periampullary cancers were higher than that of control patients with an adjusted OR of 1.35 (95% CIs: 1.16–1.57). Our results also showed that PPI exposure was slightly linked to periampullary cancers in dose‐dependent manner. A similar association was observed in patients who solely took PPI but no eradication therapy for Helicobacter pylori infection. Long‐term PPI use was associated with an increased risk of periampullary cancers in the current population‐based study. Physicians must weigh potential risks of long‐term maintenance against therapeutic benefit.

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Use of proton pump inhibitors correlates with increased risk of colorectal cancer in Taiwan

Cited by 34 publications

References 5 publications

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

A Retrospective Analysis of the Role of Proton Pump Inhibitors in Colorectal Cancer Disease Survival

Proton pump inhibitors and risk of periampullary cancers—A nested case–control study

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