Use of Podophyllin (Podophyllum Resin) in Dermatology

Nelson, Lawrence M.

doi:10.1001/archderm.1953.01540050052011

Cited by 19 publications

(3 citation statements)

References 19 publications

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“…194 Physicians in New Orleans used podophyllin for the treatment of genital warts in the 1930s. 195,196 Podophyllin resin has been used mostly in the treatment of anogenital warts. A 1990 study demonstrated a 41% complete clearance rate for patients who received up to six weekly treatments for external genital warts, but only a 17% clearance at 3 months.…”

Section: Podophyllinmentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

282

295

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Patients and clinicians experience the frustration of cutaneous viral warts caused by infection with the human papilloma virus (HPV).Warts appear in various forms on different sites of the body and include common warts (verruca vulgaris), plane or flat warts, myrmecia, plantar warts, coalesced mosaic warts, filiform warts, periungual warts, anogenital warts (venereal or condyloma acuminata), oral warts and respiratory papillomas. Cervical infection with HPV is now known to cause cervical cancer if untreated. A review of the medical literature reveals a huge armamentarium of wart monotherapies and combination therapies. Official evidence-based guidelines exist for the treatment of warts, but very few of the reported treatments have been tested by rigorous blinded, randomized controlled trials.Therefore, official recommendations do not often include treatments with reportedly high success rates, but they should not be ignored when considering treatment options. It is the purpose of this review to provide a comprehensive overview of the wart treatment literature to expand awareness of the options available to practitioners faced with patients presenting with problematic warts. Warts of the genital tract carry a much more ominous and pernicious threat for women in particular. It has been estimated that up to 70% of sexually active women become infected during their lifetime with human papillomavirus (HPV), the infective agent that causes warts. 3-5 A causal role for HPV infections in cervical cancer has been documented beyond reasonable doubt. HPV DNA is present in virtually all cervical cancer cases worldwide, with it being detected in 99.7% of an international series of cervical cancers by genetic amplification techniques and in 100% of cases as confirmed by histological review. 6,7 Cervical cancer is the most frequent common cancer in developing countries and the second most common cancer in women worldwide. 3 The association between HPV infection and cervical cancer is so strong that HPV is now considered the first positive cause of any human cancer ever identified. 3This raises the level of concerns over HPV prevention, screening and treatment from that of a nuisance condition to that of a major public health concern. Attention is beginning to focus on the viral factors that determine persistence and neoplastic progression to cancer and the possible role of HPV in other nongenital cancers (e.g., skin, upper aerodigestive tract). [8][9][10][11][12][13][14][15][16][17] Patients with warts seek advice from general practitioners, pharmacists, naturopaths, allied health professionals, family or friends, dermatologists, gynecologists, obstetricians and pediatricians for treatment and may present with recalcitrant warts that have been previously treated with anything from folk remedies to hypnosis to over-the-counter medications to more aggressive clinic-based treatments. Unfortunately, even with years of medical literature on this subject, high-quality, level I evidence for the efficacy of almost all treatments is no...

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Section: Podophyllinmentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

282

295

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“…Podophyllin has also been tried with varying success in the topical treatment of premalignant and malignant skin lesions such as actinic keratoses, keratoacanthoma, basal cell carcinoma, squamous cell carcinoma, and also as a systemic agent in the management of uterine carcinoma. [ 20 21 22 23 24 25 26 27 28 ] However, the mixed response and the high relapse rate forced researchers to abandon its use as an antineoplastic agent.…”

Section: Clinical Usesmentioning

confidence: 99%

Podophyllin in dermatology: Revisiting a historical drug

Singh

Choudhary

Ganguly

2022

Indian Dermatol Online J

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Podophyllin is a cytotoxic material extracted from Podophyllum peltatum and Podophyllum hexandrum and is widely used for the treatment of genital warts. This article reviews the chemistry of podophyllin and its active components along with the mechanism of action in various dermatoses. Furthermore, the documented uses of podophyllin in various dermatological disorders have been described along with the side effects of the drug. Based on the available literature, a clinical guideline is being proposed so as to minimize the side effects. Further studies should be carried out on its use in a lower concentration in other dermatoses, especially premalignant and malignant skin diseases.

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“…From a few open clini cal studies [1,2] it is known that podophyllin (a water-alcoholic extract from Podophyl lum peltatum) possesses antipsoriatic properties. In earlier studies, podophyllin concentrations of 5-25% have mainly been used.…”

Section: Introductionmentioning

confidence: 99%

Response of Solitary Psoriatic Plaques to Experimental Application of Podophyllotoxin

Lassus

Rosen²

1986

Dermatology

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A 16-week double-blind study of parallel groups was carried out in the treatment of 152 patients suffering from stable psoriasis vulgaris. Podophyllotoxin was applied once daily at three different concentrations in an ointment base, namely 0.1, 0.25 and 0.5%. One stable psoriatic lesion was selected and monitored during the study course. All three concentrations of podophyllotoxin induced a statistically highly significant improvement (p < 0.001) of the selected lesions. There was statistically highly significant difference between the treated and control lesions already after 2 weeks of treatment (p > 0.001), and this difference increased further during the study course. Eleven patients experienced adverse reactions – severe skin rash – spontaneously reported by the patients.

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Use of Podophyllin (Podophyllum Resin) in Dermatology

Cited by 19 publications

References 19 publications

An Armamentarium of Wart Treatments

An Armamentarium of Wart Treatments

Podophyllin in dermatology: Revisiting a historical drug

Response of Solitary Psoriatic Plaques to Experimental Application of Podophyllotoxin

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