Use of plasma glow for surface-engineering biomolecules to enhance bloodcompatibility of Dacron and PTFE vascular prosthesis

Chandy, Thomas; Das, Gladwin S.; Wilson, Robert F.; Rao, Gundu H. R.

doi:10.1016/s0142-9612(99)00231-8

Cited by 157 publications

(105 citation statements)

References 31 publications

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“…In other words, there is a higher inhibitory effect on fibrinogen deposition due to the surface modification with antiplatelet agents and plasma exposure [206]. The study suggests the possibility to control surface-induced thrombosis via the immobilization of biomolecules on collagen-laminin modified biomaterials.…”

Section: Poly(tetrafluoroethylene)mentioning

confidence: 82%

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Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,376

638

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Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #

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Section: Poly(tetrafluoroethylene)mentioning

confidence: 82%

“…Chandy et al prepared a series of surface coatings by modifying the argon plasma-treated PTFE (Teflon) and polyethylene-terephthalate (Dacron) grafts with collagen IVand laminin and subsequently immobilizing bioactive molecules like PGE 1 , heparin or phosphatidyl choline via the carbodiimide functionalities [206]. Fig.…”

Section: Poly(tetrafluoroethylene)mentioning

confidence: 99%

Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,376

638

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show abstract

“…), as well as in the electronics industry (electrical parts, transparent substrates for flexible electrical devices such as organic light emitting diodes (OLED's), solar cells etc.) and the biomedical industry (human implants such as vascular grafts, prosthetic heart valves and for endothelial cell growth) [2][3]. PET is a thermoplastic, long chain polymer.…”

Section: Introductionmentioning

confidence: 99%

Proton-radiation resistance of poly(ethylene terephthalate)–nanodiamond–graphene nanoplatelet nanocomposites

et al. 2015

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“…28,29 In contrast to largediameter vascular grafts (i.e., larger than 5 mm inside diameter) which remain excellent for more than 10 years after implantation, 30 small-diameter vascular grafts 31 occlude rapidly after implantation. 32 Several different approaches have used plasma modification to treat the lumenal surfaces of polyethylene terephthalate 33,34 (PET, Dacron), expanded polytetrafluoroethylene 33,35 (ePTFE), polyethylene 36 (PE), and polyurethane 8 tubes. The traditional method for coating the lumenal surfaces of these polymer tubes uses plasma polymerization (PP) of a monomer gas, so as to modify the surface of the material directly or to introduce functional groups that can later be used to immobilize specific biomolecules or proteins.…”

Section: Introductionmentioning

confidence: 99%

“…7 This is due to the inherent drawback when using PP where continuous consumption of the monomer gas and removal of the residual gases is a mandatory condition for the uniformity of the coating. 1,7 To treat small diameter tubing with lengths longer than a few centimeters, the rf electrodes must be moved with respect to the tubing 2,33,35,36 or the tubing must be moved continuously with respect to the electrodes. 1,7 Therefore, precise control of the speed of the electrodes or tubing, whichever is moving, is necessary for a uniform thickness of the coating along the tube.…”

Section: Introductionmentioning

confidence: 99%

Reduced adhesion of human blood platelets to polyethylene tubing by microplasma surface modification

Lauer

Shohet

Albrecht

et al. 2004

Journal of Applied Physics

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A hollow-cathode microplasma modified the lumenal surface of small-diameter polyethylene (PE) tubing. A microwave cavity diagnostic was used to measure the density of the microplasma. Plasma light output was observed with a monochromator at various positions along the PE tube to assess uniformity. Treatment effectiveness was evaluated by measuring the variation in capillary rise at various positions along the tubing. A correlation between the properties of the inner surface of the PE tubing and the emitted light intensity was found. A poly(ethylene oxide) surfactant was immobilized to the lumenal surface of the PE tubing with an argon microplasma discharge. To test hematocompatibility, an in vitro blood-flow loop circulated heparinized human blood through both a plasma-treated and -untreated PE tubes, simultaneously. After blood exposure, the tubes were examined with a scanning electron microscope to assess the density of adhering platelets along the length of the tubes. By modifying the plasma parameters, the uniformity of the microplasma treatment along the tubing can be optimized.

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Use of plasma glow for surface-engineering biomolecules to enhance bloodcompatibility of Dacron and PTFE vascular prosthesis

Cited by 157 publications

References 31 publications

Plasma-surface modification of biomaterials

Plasma-surface modification of biomaterials

Proton-radiation resistance of poly(ethylene terephthalate)–nanodiamond–graphene nanoplatelet nanocomposites

Reduced adhesion of human blood platelets to polyethylene tubing by microplasma surface modification

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