Use of papaya leaf extract in neonatal thrombocytopenia

Pandita, Aakash; Gupta, Girish; Singh, Rachna

doi:10.1002/ccr3.2025

Cited by 9 publications

(10 citation statements)

References 6 publications

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“…In general, C. papaya leaf juice was reportedly given at doses ranging from 2.5 mL in children to up to 150 mL a day in adults ( Table 4 ). The youngest patient to be safely administered with 20 mg/kg C. papaya leaf standardised aqueous extract (Caripill, Microlabs) was a preterm neonate at 23 days of life [ 47 ]. In terms of duration, C. papaya leaf extract and juice were administered only for a short duration of three to five days in randomised controlled and quasiexperimental trials, mostly in dengue patients.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, with currently available evidence, it is challenging to deduce a safe dose of C. papaya leaf specific to its phytochemical composition. Specifically in paediatric cases, only one randomised controlled trial among dengue-infected children was conducted and published [ 48 ], while one case series [ 32 ] and one case report [ 47 ] documented the safe administration of C. papaya leaf extract in young children. Future trials with detailed quantitative assessment of phytochemical analysis, specialised investigations in paediatric population, and improved ADR reporting are needed to strengthen safety findings.…”

Section: Discussionmentioning

confidence: 99%

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Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions

Lim

Chan

Japri

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Introduction. The Carica papaya L. leaf is gaining interest as a potential therapeutic agent for alleviating dengue- and non-dengue-associated thrombocytopaenia. In that regard, safety considerations are as important as efficacy potential. The safety evaluation of botanical products for human use is complicated by variable formulations, complex phytochemical composition, and extrinsic toxicants. This review aimed to systematically collate related safety clinical and preclinical data, as well as reports on herb-drug interactions of C. papaya leaf consumption. Methods. A systematic search using predetermined keywords on electronic databases (MEDLINE, Cochrane Library Central, LILACS, and Web of Science) and grey literature was conducted. Relevant clinical and preclinical studies were identified, screened, and analysed to present an overall safety profile of C. papaya leaf consumption. Results. A total of 41 articles were included (23 clinical, 5 ongoing trials, and 13 preclinical) for descriptive analysis on study characteristics, adverse reactions, toxicity findings, and herb-drug interactions, from which 13 randomised controlled and quasiexperimental trials were further assessed for risk of bias and reporting quality. Overall, C. papaya leaf consumption (in the form of juice and standardised aqueous extract) was well tolerated by adult humans for short durations (<five days) while one randomised controlled trial reported safe consumption of C. papaya leaf standardised aqueous extract in children (aged 1–12 years). Minor gastrointestinal side effects were most commonly reported. There are concerns about hepatotoxicity and reproductive toxicity in long-term use, supported by animal studies. Unfavourable herb-drug interactions with metformin, glimepiride, digoxin, ciprofloxacin, and artemisinin were accounted. Conclusion. C. papaya leaf consumption in adults is generally safe for short-term use though cautioned in pregnancy and people with liver impairment. It has potential herb-drug interactions with oral hypoglycaemic agents, p-glycoprotein substrates, and antibiotics with cation chelating properties.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions

Lim

Chan

Japri

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…However, to get similar efficacy like eucalyptus oil, more than 20 times higher concentration of neem oil was required [27]. Neem infused water [28], papaya leaf juice [29][30][31][32][33][34][35], Gulancha (Tinospora cordifolia) and Tit Begun (Solanum xanthocarpum) shown to increase both blood platelets and WBC count, two of which are the worst side effects of dengue fever [36]. However, none of the above mentioned have been reported as safe in infant and pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Dengue Epidemic Situation in Bangladesh

Mohiuddin¹

2019

J Clin Case Stu

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Volume 4 -Issue 3 for the recommended three doses [4]. Some available mosquito repellant creams are hiking 10 times price than actual price, so how much Dengvaxia ® will hike, if available, we can very well imagine and which mosquito-borne disease will be epidemic next time is uncertain. So, we have to focus on mosquito bite prevention, not dengue or chikungunya. Climate change is a very important factor of Flavivirus (genus type of dengue virus) transmission but not the sole factor [5]. Along with climate change, aberrant use of pesticides and their resistance is also noted in recent dengue affected countries. Most commonly used insecticides in households (Metafluthrin & D-allethrin), mosquito coils repel mosquito and kerosene fog by city corporation kills larvae and ensures effective adult mosquito eradication for short-term. The use of coil protective stands is necessary to prevent fire incident and accidental touch. Mosquito proof nets are applied in many households and air blower in a few supermarket entrances are not enough for disease prevention and mostly unaffordable/unsuitable for general use. Full-sleeve cloths can reduce mosquito bite incidents but rarely ensures prevention from mosquito-transmitted viral diseases. Permethrin/malathion-treated military clothing has shown to be effective in significantly reducing mosquito bites in the covered regions [6]. There is also an abundance of fixed or moveable electric devices (for example: mosquito bats or electric coils) and wearable devices that are available, including bracelets, sonic devices, clothing, and skin patches. Their accessibility, availability, affordability and practical uses varied among different people.

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“…Papaya leaf extract has been reported to cause membrane stabilization, which may facilitate the reversal of peripheral platelet destruction by dengue virus ( Ranasinghe et al, 2012 ). The possible role of antioxidant and free radical scavenging properties of papaya leaf extract in aiding the prevention of hemolysis and bleeding have also been suggested ( Pandita et al, 2019 ). However, dengue virus induces the reduction in proliferation of platelets by inhibiting megakaryocytopoiesis or inhibiting differentiation of stem cells into megakaryocyte precursor cells ( da Costa Barros and de-Oliveira-Pinto, 2018 ).…”

Section: Pharmacological and Therapeutic Potentials Of C Papaya Leaves In Denguementioning

confidence: 99%

Dengue Fever: Therapeutic Potential of Carica papaya L. Leaves

2021

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Dengue, a very widespread mosquito-borne infectious disease caused by Aedes aegypti virus, has been occurring during the monsoons every year. The prevalence and incidence of dengue fever and death due to its complications have been increased drastically in these recent years in Bangladesh, Philippines, Thailand, Brazil, and India. Recently, dengue had spread in an epidemic form in Bangladesh, Thailand, and Philippines. Although the infection affected a large number of people around the world, there is no established specific and effective treatment by synthetic medicines. In this subcontinent, Malaysia could effectively control its incidences and death of patients using alternative medication treatment mainly prepared from Carica papaya L. leaves along with proper care and hospitalization. Papaya leaves, their juice or extract, as well as their different forms of preparation have long been used traditionally for treating dengue fever and its complications to save patients’ lives. Although it is recommended by traditional healers, and the general public use Papaya leaves juice or their other preparations in dengue fever, this treatment option is strictly denied by the physicians offering treatment in hospitals in Bangladesh as they do not believe in the effectiveness of papaya leaves, thus suggesting to patients that they should not use them. In Bangladesh, 1,01,354 dengue patients have been hospitalized, with 179 deaths in the year 2019 according to information from the Institute of Epidemiology, Disease Control, and Research as well as the Directorate General of Health Services of Bangladesh. Most of the patients died because of the falling down of platelets to dangerous levels and hemorrhage or serious bleeding. Therefore, this paper aims to critically review the scientific basis and effectiveness of Carica papaya L. leaves in treating dengue fever based on preclinical and clinical reports. Thrombocytopenia is one of the major conditions that is typical in cases of dengue infection. Besides, the infection and impairment of immunity are concerned with dengue patients. This review summarizes all the scientific reports on Carica papaya L. for its ability on three aspects of dengue: antiviral activities, prevention of thrombocytopenia and improvement of immunity during dengue fever.

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Use of papaya leaf extract in neonatal thrombocytopenia

Cited by 9 publications

References 6 publications

Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions

Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions

Dengue Epidemic Situation in Bangladesh

Dengue Fever: Therapeutic Potential of Carica papaya L. Leaves

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