Use of oxygen-ozone therapy in the treatment of fibromyalgia

Abstract

Fibromyalgia (FM) is a pathology that is manifested by a spectrum of heterogeneous symptoms that are difficult to frame, from both a diagnostic and therapeutic point of view. On one hand, the clinical features are highly variable, and on the other, the pathophysiology has yet to be fully clarified. This paper aims to highlight how oxygen ozone -administered using a precise protocol from the Scientific Society of Oxygen Ozone Therapy -is able to act on several levels of the pathophysiology of FM by virtue of its intrinsic biochemical mechanisms, making it a viable option for treating the disease. The following case studya 45 year old woman who came to our attention due to diffuse pain and a feeling of general tiredness -responded positively to a standard treatment with oxygen-ozone therapy delivered via bi-weekly sessions, for a total of 12 sessions from September to October 2016. The treatment was followed by a maintenance therapy of about one session a month. One month after the end of the 12 sessions, the patient reported a significant improvement in pain, mood, and a significant reduction in fatigue, a new feeling of well-being and an improved quality of sleep. In the light of these results, oxygen-ozone therapy emerges as a viable therapeutic option for the treatment of FM patients.

The effectiveness of major ozone autohemotherapy in the treatment of fibromyalgia syndrome

“…In a case report published in 2017, MAH was applied twice a week to a 45-year-old female patient with FMS. In the components of the Fibromyalgia Survey Questionnaire, the Widespread Pain Index decreased from 15 to 7, and the Symptoms Severity Scale from 7 to 1 at the end of 12 sessions [20].…”

Fibromialgia, disfunción mitocondrial, estrés oxidativo e inflamación: Ozono como tratamiento multidiana. Caso clínico y revisión de la literatura.

“…Balestrero y cols. (2017) presentó el caso clínico de una paciente de 45 años quien, tras un total de 12 sesiones de autohemoterapia (2/semana por 6 semanas), presentó mejoría del dolor, el ánimo y la fatiga, evidenciado por el cuestionario FSQ (fibromyalgia survey questionnaire) (17). Bocci y Borreli (2002) trataron a 4 pacientes fibromiálgicos con autohemoterapia más CoQ10, disminuyendo los síntomas en las pacientes con FM (189.…”

Analgetic effect of ozone therapy: myths of reality?

“…For treating an acute and chronic pain syndrome, ozone is administered intraarticularly, intramuscularly, intrave� nously, subcutaneously, and even directly in intervertebral discs (intradiscally). 28,45,46 The routes o� o�ygen�ozone mi�� ture administration may vary over the course o� the treat� ment depending on the �eatures o� the pain syndrome and the disease course.…”

“…Laboratory studies confirmed that high IL-8 levels were indeed associated with pain, while IL�6 concen� tration grew in cases o� hyperalgesia, e�cessive �atigue, and depression. 15 A team o� scientists led by Balestrero (2017) presented evidence of the efficacy of ozone therapy for treatment o� FM patients. They used treatment regimen based on Scientific Society of Oxygen Ozone Therapy Protocol (SIOOT), which involved influencing the process with the due account to pathogenetic �eatures o� FM.…”

“…Their work stressed the fact that the lack of efficacy and short-term ef� �ect o� medicinal therapy were associated with the negative points o� the previous treatment courses administered to the patients. 46 The topicality o� ozone therapy �or treatment o� FM patients was substantiated by recognition of efficacy of this method not only �or correcting the e��ects o� o�idative stress, but also �or restoring the �unctional capacity o� the antio�idant system and modulating the immune response o� the patient's body. 14,20,21 The condition �or participating in the study was com� pliance of symptoms with fibromyalgia survey quesion� naire (FSQ) and fibromyalgia impact questionnaire-revised (FIQR) scoring recommended by the American College o� Rheumatology.…”