Use of oral ketoconazole to prevent postoperative erections following penile surgery

Evans, Karen; Peterson, Andrew C.; Ruiz, Henry E.; Costabile, Raymond A.

doi:10.1038/sj.ijir.3901160

Cited by 13 publications

(11 citation statements)

References 10 publications

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“…Ketoconazole and Itraconazole , as 14-α demethylase (CYP51A1) inhibitors, are synthetic antifungal drugs [23] and could be used to treat refractory bone pain and neurologic injury in patients with advanced metastatic prostate cancer [26], [27]. In this study, both drugs were identified to bind to ERα and ERβ with IC 50 or EC 50 value less than 1 µM (Figure 5).…”

Section: Discussionmentioning

confidence: 89%

“…For example, ketoconazole inhibits the production of testosterone, and has been used by urologists to treat refractory bone pain and impending neurologic injury in patients with advanced metastatic prostate cancer [26], [27], but the molecular mechanism is unknown. In this study, ketoconazole was found to selectively inhibit ERβ with IC 50 value of 0.79 µM and showed good antiproliferative activity on human MDA-MB-231 breast cancer cell line with IC 50 value of 8.95 µM, which indicated that ketoconazole may have more broad-spectrum anti-cancer indications with therapeutic effects of breast cancer in clinic.…”

Section: Resultsmentioning

confidence: 99%

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Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

et al. 2012

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Drug-target interaction (DTI) is the basis of drug discovery and design. It is time consuming and costly to determine DTI experimentally. Hence, it is necessary to develop computational methods for the prediction of potential DTI. Based on complex network theory, three supervised inference methods were developed here to predict DTI and used for drug repositioning, namely drug-based similarity inference (DBSI), target-based similarity inference (TBSI) and network-based inference (NBI). Among them, NBI performed best on four benchmark data sets. Then a drug-target network was created with NBI based on 12,483 FDA-approved and experimental drug-target binary links, and some new DTIs were further predicted. In vitro assays confirmed that five old drugs, namely montelukast, diclofenac, simvastatin, ketoconazole, and itraconazole, showed polypharmacological features on estrogen receptors or dipeptidyl peptidase-IV with half maximal inhibitory or effective concentration ranged from 0.2 to 10 µM. Moreover, simvastatin and ketoconazole showed potent antiproliferative activities on human MDA-MB-231 breast cancer cell line in MTT assays. The results indicated that these methods could be powerful tools in prediction of DTIs and drug repositioning.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

et al. 2012

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“…41 In addition to its antifungal action, ketoconazole has a resultant side effect that creates a reduction in testosterone levels which has been observed in the treatment of metastatic prostate cancer, preventing postoperative erections and various other medical conditions. [41][42][43] This decrease in testosterone is the reasoning behind the use of ketoconazole in the treatment of recurrent priapism. All patients receiving ketoconazole should be monitored by a physician and given daily prednisone due to ketoconazole's blocking action on the production of adrenal steroids.…”

Section: Hormonal Therapymentioning

confidence: 99%

Medical management of ischemic stuttering priapism: a contemporary review of the literature

Levey¹,

Kutlu²,

Bivalacqua³

2011

Asian J Androl

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Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction (ED). Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease (SCD) and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.

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“…-Cetoconazol, por seu efeito antiandrogênico moderado 44,45 . Todos os casos relatados na literatura são de uso pós-operatório a curto prazo após cirurgia peniana em pacientes sem doença hematológica, e há algumas preocupações teóricas em relação à indução de resistência com o uso prolongado de uma droga antifúngica.…”

Section: Tratamentounclassified

Priapism in children: review of pathophysiology and treatment

Jesus¹,

Dekermacher²

2009

J Pediatr (Rio J)

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Objective: Priapism may cause serious sequelae concerning the future sex life of the patient, as it can determine impotence, erectile dysfunction or psychogenic sexual aversion. It is a common symptom of sickle cell disease in children and adolescents. There are few good quality evidence manuscripts about the problem in current medical literature. Sources:Literature review on the databases MEDLINE and LILACS covering the period from 1966 to 2008. Summary of the findings:The basis for the treatment of low flow priapism includes treating sickle cell disease and the usage of intracavernous adrenergic agents as necessary. Surgery is indicated in a minority of cases. The treatment of pediatric cases demands dose adjustments, adequate drug choice and sedoanalgesia to cover procedures involving pain or trauma. Conclusions:A new physiopathologic theory concerning sickle cell disease, which questions the traditional vascular blockage mechanisms by deformed red cells and proposes that endothelial inflammatory activation is the main cause of clinical problems, allows to propose new therapeutic maneuvers to solve sickle cell priapism. The absence of good quality evidence to treat sickle cell priapism suggests the necessity to conduct good prospective multicenter protocols to investigate the condition.J Pediatr (Rio J). 2009;85(3):194-200: Priapism, sickle cell disease, children. ResumoObjetivo: O priapismo pode causar sequelas graves em relação à vida sexual futura do paciente, pois pode determinar impotência, disfunção erétil ou aversão sexual psicogênica. É um sintoma comum da doença falciforme em crianças e adolescentes. Há poucos estudos com evidências de qualidade sobre esse problema na literatura médica atual. Fontes dos dados:Revisão da literatura utilizando as bases de dados MEDLINE e LILACS no período de 1966 a 2008. Síntese dos dados:A base para o tratamento de priapismo de baixo fluxo inclui o tratamento da doença falciforme e o uso de agentes adrenérgicos por administração intracavernosa conforme necessário. Indica-se cirurgia em uma minoria de casos. O tratamento de casos pediátricos exige ajuste de doses, escolha adequada de medicamentos e sedoanalgesia para procedimentos envolvendo dor ou trauma. Conclusões:Uma nova teoria fisiopatológica relativa à doença falciforme, que questiona os mecanismos tradicionais de bloqueio vascular por hemácias deformadas e propõe que a ativação inflamatória endotelial é a principal causa de problemas clínicos, permite propor novas manobras terapêuticas para lidar com o priapismo na doença falciforme. A ausência de evidência de qualidade para tratar o priapismo na doença falciforme sugere a necessidade de conduzir bons protocolos prospectivos multicêntricos para investigar essa condição.J Pediatr (Rio J). 2009;85(3):194-200 Artigo submetido em 22.09.08, aceito em 12.11.08.

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Use of oral ketoconazole to prevent postoperative erections following penile surgery

Cited by 13 publications

References 10 publications

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

Medical management of ischemic stuttering priapism: a contemporary review of the literature

Priapism in children: review of pathophysiology and treatment

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