Use of Hyaluronidase With Local Anesthesia in Ophthalmology

Orbital Dynamics and Efficacy of Retrobulbar Anesthesia With and Without Hyaluronidase in Vitreoretinal Surgery

“…RAI with and without hyaluronidase has been the standard of care for more than 60 years. [1][2][3][4][5] Although it has been suggested that the use of hyaluronidase improves block efficacy, previous comparisons of block efficacy have been inconclusive. 2,7,8 Adding hyaluronidase to the anesthetic mixture adds complexity, cost, and depending on compliance and regulatory realities, the requirement to use a licensed compounding pharmacy to formulate the blocks.…”

Orbital Dynamics and Efficacy of Retrobulbar Anesthesia With and Without Hyaluronidase in Vitreoretinal Surgery

“…RAI with and without hyaluronidase has been the standard of care for more than 60 years. [1][2][3][4][5] Although it has been suggested that the use of hyaluronidase improves block efficacy, previous comparisons of block efficacy have been inconclusive. 2,7,8 Adding hyaluronidase to the anesthetic mixture adds complexity, cost, and depending on compliance and regulatory realities, the requirement to use a licensed compounding pharmacy to formulate the blocks.…”

A Comparative Study of Sodium Bicarbonate and Hyaluronidase on Pain Perception, Anesthesia, and Akinesia during Peribulbar Anesthesia for Cataract Surgery

“…In 1949, Atkinson reported the advantages of hyaluronidase in anesthetic solution to allow for injecting a large volume of anesthetic agent and to achieve early akinesia and anesthesia. [ 2 ] Ophthalmologists are shifting to topical anesthesia following the demands of patients because of the pain of the injection during peribulbar anesthesia. However, many studies have shown that surgeon comfort was better with peribulbar anesthesia as compared to topical anesthesia.…”

Does the addition of hyaluronidase improve the quality of peribulbar anesthesia in cataract surgery? – A randomized double blinded study

“…Combinations of hyaluronidase and local anesthesia have been used in the past with other regional blocks, but have lost popularity over a period of time 8 . Yet, hyaluronidase, continues to retain its place in ophthalmic anesthesia for over six decades 4 . Several workers have proposed different rationales justifying the inclusion of hyaluronidase in ophthalmic local anesthesia.…”

Orbital Dynamics and Efficacy of Retrobulbar Anesthesia With and Without Hyaluronidase in Vitreoretinal Surgery

“…RAI with and without hyaluronidase has been the standard of care for more than 60 years. [1][2][3][4][5] Although it has been suggested that the use of hyaluronidase improves block efficacy, previous comparisons of block efficacy have been inconclusive. 2,7,8 Adding hyaluronidase to the anesthetic mixture adds complexity, cost, and depending on compliance and regulatory realities, the requirement to use a licensed compounding pharmacy to formulate the blocks.…”

A Comparative Study of Sodium Bicarbonate and Hyaluronidase on Pain Perception, Anesthesia, and Akinesia during Peribulbar Anesthesia for Cataract Surgery

“…In 1949, Atkinson reported the advantages of hyaluronidase in anesthetic solution to allow for injecting a large volume of anesthetic agent and to achieve early akinesia and anesthesia. [ 2 ] Ophthalmologists are shifting to topical anesthesia following the demands of patients because of the pain of the injection during peribulbar anesthesia. However, many studies have shown that surgeon comfort was better with peribulbar anesthesia as compared to topical anesthesia.…”

Does the addition of hyaluronidase improve the quality of peribulbar anesthesia in cataract surgery? – A randomized double blinded study

“…Combinations of hyaluronidase and local anesthesia have been used in the past with other regional blocks, but have lost popularity over a period of time 8 . Yet, hyaluronidase, continues to retain its place in ophthalmic anesthesia for over six decades 4 . Several workers have proposed different rationales justifying the inclusion of hyaluronidase in ophthalmic local anesthesia.…”

Orbital Dynamics and Efficacy of Retrobulbar Anesthesia With and Without Hyaluronidase in Vitreoretinal Surgery

“…RAI with and without hyaluronidase has been the standard of care for more than 60 years. [1][2][3][4][5] Although it has been suggested that the use of hyaluronidase improves block efficacy, previous comparisons of block efficacy have been inconclusive. 2,7,8 Adding hyaluronidase to the anesthetic mixture adds complexity, cost, and depending on compliance and regulatory realities, the requirement to use a licensed compounding pharmacy to formulate the blocks.…”

A Comparative Study of Sodium Bicarbonate and Hyaluronidase on Pain Perception, Anesthesia, and Akinesia during Peribulbar Anesthesia for Cataract Surgery

“…In 1949, Atkinson reported the advantages of hyaluronidase in anesthetic solution to allow for injecting a large volume of anesthetic agent and to achieve early akinesia and anesthesia. [ 2 ] Ophthalmologists are shifting to topical anesthesia following the demands of patients because of the pain of the injection during peribulbar anesthesia. However, many studies have shown that surgeon comfort was better with peribulbar anesthesia as compared to topical anesthesia.…”

Does the addition of hyaluronidase improve the quality of peribulbar anesthesia in cataract surgery? – A randomized double blinded study

“…Combinations of hyaluronidase and local anesthesia have been used in the past with other regional blocks, but have lost popularity over a period of time 8 . Yet, hyaluronidase, continues to retain its place in ophthalmic anesthesia for over six decades 4 . Several workers have proposed different rationales justifying the inclusion of hyaluronidase in ophthalmic local anesthesia.…”