Use of High-Flow Nasal Cannula for Immunocompromise and Acute Respiratory Failure: A Systematic Review and Meta-Analysis

Wang, Yiwei; Ni, Yingmeng; Sun, Jikui; Liang, Zongan

doi:10.1016/j.jemermed.2020.01.016

Cited by 16 publications

(12 citation statements)

References 53 publications

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“…Recent meta-analyses focusing on immunocompromised patients [35,36] have included the studies presented here and all conclude that use of NHF is associated with a decreased intubation rate but with no impact on mortality.…”

Section: Nhf In Immunocompromised Patientsmentioning

confidence: 82%

Use of nasal high flow oxygen during acute respiratory failure

et al. 2020

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Nasal high flow (NHF) has gained popularity among intensivists to manage patients with acute respiratory failure. An important literature has accompanied this evolution. In this review, an international panel of experts assessed potential benefits of NHF in different areas of acute respiratory failure management. Analyses of the physiological effects of NHF indicate flow-dependent improvement in various respiratory function parameters. These beneficial effects allow some patients with severe acute hypoxemic respiratory failure to avoid intubation and improve their outcome. They require close monitoring to not delay intubation. Such a delay may worsen outcome. The ROX index may help clinicians decide when to intubate. In immunocompromised patients, NHF reduces the need for intubation but does not impact mortality. Beneficial physiological effects of NHF have also been reported in patients with chronic respiratory failure, suggesting a possible indication in acute hypercapnic respiratory failure. When intubation is required, NHF can be used to pre-oxygenate patients either alone or in combination with non-invasive ventilation (NIV). Similarly, NHF reduces reintubation alone in low-risk patients and in combination with NIV in high-risk patients. NHF may be used in the emergency department in patients who would not be offered intubation and can be better tolerated than NIV.

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Section: Nhf In Immunocompromised Patientsmentioning

confidence: 82%

Use of nasal high flow oxygen during acute respiratory failure

et al. 2020

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“…Full-text review of 38 potentially eligible studies identified 20 eligible studies. Of these, 17 were systematic reviews (SRs) 15,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] and three were RCTs [41][42][43] (Fig. 1).…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission

Agarwal

Basmaji

Muttalib

et al. 2020

Can J Anesth/J Can Anesth

163

160

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Purpose We conducted two World Health Organizationcommissioned reviews to inform use of high-flow nasal cannula (HFNC) in patients with coronavirus disease (COVID-19). We synthesized the evidence regarding efficacy and safety (review 1), as well as risks of droplet dispersion, aerosol generation, and associated transmission (review 2) of viral products. Source Literature searches were performed in Ovid MEDLINE, Embase, Web of Science, Chinese databases, and medRxiv. Review 1: we synthesized results from randomized-controlled trials (RCTs) comparing HFNC to conventional oxygen therapy (COT) in critically ill patients with acute hypoxemic respiratory failure. Review 2: we narratively summarized findings from studies evaluating droplet dispersion, aerosol generation, or infection transmission associated with HFNC. For both reviews,

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“…Another study shows that HFNC combined with an external diaphragmatic pacemaker (EDP) can significantly shorten the length of NICU stay in patients with severe intracerebral hemorrhage ( Yan et al, 2020 ). Wang et al (2020) found the ICU stay of the HFNC group was shorter than the NIV group. Through linear regression analysis, we found that HFNC was one of the important factors for both of them ( Tables 8 , 9 ).…”

Section: Discussionmentioning

confidence: 87%

“…There was no difference in mortality during hospitalization between the two groups in our study. Some studies showed that HFNC reduced mortality in hospitals ( Frat et al, 2015 ; Kim et al, 2018 ; Nagata et al, 2018 ; Deng et al, 2021 ), while other studies showed that HFNC did not ( Wang et al, 2020 ). We speculated that the severity of the primary disease might be the main factor affecting mortality during hospitalization, which needs further study.…”

Section: Discussionmentioning

confidence: 99%

High Flow Nasal Cannula Decreased Pulmonary Complications in Neurologically Critically Ill Patients

Wang

Yang

et al. 2022

Front. Hum. Neurosci.

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Objective: Pulmonary complications could badly affect the recovery of neurological function and neurological prognosis of neurological critically ill patients. This study evaluated the effect of high-flow nasal cannula (HFNC) therapy on decreasing pulmonary complications in neurologically critically ill patients.Patients and Methods: The patients admitted to the intensive care unit (ICU) with serious neurological disease and receiving oxygen therapy were retrospectively reviewed (Ethical No. IRB2021-YX-001). Patients were divided into the HFNC group and the conventional oxygen therapy (COT) group. We analyzed the data within these two groups, including patients’ baseline data, short-term outcomes of respiratory complications, general outcomes including hospital stay, ICU stay and mortality, and neurological functions. To analyze the relevant factors, we performed multivariable logistic regression analysis.Results: A total of 283 patients met the criteria, including 164 cases in the HFNC group and 119 cases in the COT group. The HFNC group had remarkably less mechanical ventilation requirement with lower phlegm viscosity. Even more, ICU stay and total hospital stay were significantly shortened in the HNFC group.Conclusion: HFNC decreased pulmonary complications in neurologically critically ill patients and improved recovery of neurological function and neurological prognosis.

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Use of High-Flow Nasal Cannula for Immunocompromise and Acute Respiratory Failure: A Systematic Review and Meta-Analysis

Cited by 16 publications

References 53 publications

Use of nasal high flow oxygen during acute respiratory failure

Use of nasal high flow oxygen during acute respiratory failure

High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission

High Flow Nasal Cannula Decreased Pulmonary Complications in Neurologically Critically Ill Patients

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