“…The latter are frequently used because of their simplicity and lower cost [23,24]. Because HMEs are placed between the Y-piece and the patient, they add substantial deadspace to the circuit [25,26,27,28], and they can also marginally increase the resistance to flow [29,30]. It has been suggested in intubated patients that an increase of 5-10 cmH 2 O in the pressure support (PS) level is necessary to compensate the effects of the HME deadspace.…”