Use of handheld reflectance confocal microscopy for in vivo diagnosis of solitary facial papules: a case series

Abstract

For clinically and dermoscopically equivocal small papules on curved facial surfaces, handheld RCM may be particularly helpful in differentiating benign lesions from skin cancer.

Accuracy of in vivo confocal microscopy for diagnosis of basal cell carcinoma: a comparative study between handheld and wide‐probe confocal imaging

“…Handheld reflectance confocal microscopy imaging was performed with commercially‐available in vivo RCM system (Vivascope3000; CaliberID) as previously described . In brief, the HH‐RCM uses 830 nm laser and is characterized by horizontal resolution of 1.25 μm, vertical resolution of 5 μm, and maximal imaging depth of about 250 μm which corresponds to the superficial reticular dermis.…”

“…However, the TWP‐RCM is bulky and provides limited access to curved surfaces, such as the nose, ear and peri‐orbital regions where BCC frequently arises. Recently, a handheld‐RCM probe (HH‐RCM, Vivascope 3000; CaliberID) has been introduced to clinical practice . The HH‐RCM has a smaller probe and is more accessible for application to the curved facial surfaces.…”

Through the looking glass: Basics and principles of reflectance confocal microscopy

“…Because of its narrow probe, however, the handheld RCM has a field of view limited to 1 3 1 mm. 2 In its current form, the dimensions of the wide-probe RCM imaging station are 30 3 23 3 54 in (76.2 3 58. 4 3 137.2 cm); this device can be stowed at the corner of a standard examination room and can be mobilized between examination rooms.…”

Noninvasive in vivo confocal laser scanning microscopy is effective in differentiating allergic from nonallergic equivocal patch test reactions

“…However, though CLSM provides crucial information when evaluating equivocal reactions, the technology is expensive and time consuming. A newly available complimentary commercial product, a handheld CLSM device [25], might shorten the time required for data acquisition; however, it does not alter financial cost. Further studies are required to evaluate its cost-effectiveness in daily patch test practice.…”