1998
DOI: 10.1590/s0104-79301998000100003
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Abstract: Sequelae due to testicular biopsy such as hemorrhage, adhesion and fibrosis may be limiting factors to the use of this surgical procedure. Fibrin glue (FG) derived from snake venom was used to minimize these sequelae, as well as to evaluate its healing property in tunica vaginalis and scrotal skin of rams. Applicability of fibrin glue derived from snake venom was tested in different tissues of other animals such as in sciatic nerve and colon of rats and skin of rabbits. In the present study, 30 healthy adult r… Show more

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Cited by 15 publications
(12 citation statements)
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“…Factor XIII, when activated by thrombin in the presence of calcium (Ca 2+ ), reacts with the fibrin polymers, forming a stable and insoluble clot (Martinowitz and Spotnitz, 1997). These glues are used for tissue regeneration procedures in different areas of medicine as hemostatic agents, healing inducers, cavity sealants, and drug-delivery vehicles (Borst et al, 1982;Kram et al, 1989;Alving et al, 1995;Carvalho et al, 1997;Sartori Filho et al, 1998;Leite et al, 2000;Rahal et al, 2004;Dal Pizzol et al, 2009). However, the role of fibrin sealants in the healing of bone fractures and osteogenesis is not fully understood, with some studies recommending its application, whereas others do not (Abiraman et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…Factor XIII, when activated by thrombin in the presence of calcium (Ca 2+ ), reacts with the fibrin polymers, forming a stable and insoluble clot (Martinowitz and Spotnitz, 1997). These glues are used for tissue regeneration procedures in different areas of medicine as hemostatic agents, healing inducers, cavity sealants, and drug-delivery vehicles (Borst et al, 1982;Kram et al, 1989;Alving et al, 1995;Carvalho et al, 1997;Sartori Filho et al, 1998;Leite et al, 2000;Rahal et al, 2004;Dal Pizzol et al, 2009). However, the role of fibrin sealants in the healing of bone fractures and osteogenesis is not fully understood, with some studies recommending its application, whereas others do not (Abiraman et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, patients may develop antibodies against bovine thrombin 13 . In an attempt to overcome these difficulties, another sealant consisting of a thrombin-like enzyme extracted from snake venom and fibrinogen obtained from large animals to replace human components has shown excellent results in experimental studies on the regeneration of different tissues [14][15][16][17][18] , in mesenchymal cell cultures 19 , and in the healing of skin wound, venous ulcers and gingival graft sutures in humans 20,21 . This new sealant is a biodegradable product that does not cause adverse reactions, does not contain human blood components, has good adhesive capacity, and does not transmit infectious diseases 22 .…”
Section: Introductionmentioning
confidence: 99%
“…It also uses a thrombin-like enzyme from snake venom that is several times more potent than bovine thrombin. The product has been used successfully in experimental reparation of peripheral nerves (5,21), rat colon anastomosis (8), testicular biopsy of rams (16), fixation of skin flaps (19), and fixation of skin grafting of the nasolabial folds in humans (18).…”
Section: Introductionmentioning
confidence: 99%