Globally, the use of electronic cigarettes (e-cigarettes) among adolescents remains to increase. E-cigarette use in Yogyakarta City is the highest in Indonesia. Research needs to be conducted as a database for policymaking on tobacco control, especially the use of e-cigarettes in the community.This study aimed to describe the pattern of the use of e-cigarettes among adolescents. Furthermore, analyzing the relationship between age, sex, and knowledge about the dangers of e-cigarettes with e-cigarette use among adolescents. This research used a quantitative method with a cross-sectional design in Yogyakarta city. There were 210 adolescents as the sample by stratified cluster sampling strategy. Seven equivalent high schools were selected as research locations. The selection of schools performed with the lottery. The variables included age, sex, and knowledge. Data is collected through WhatsApp media using google Forms by the class teacher coordinator. Data analysis was carried out by univariate and bivariate using SPSS 22 applications.The number of adolescents who smoked was 85 (40,5%), and the use of e-cigarettes was 51 (24,3%). The pattern of e-cigarettes use among adolescents is divided into four: using conventional cigarettes 34 (16,2%), using e-cigarettes 18 (4,3%) ; using e-cigarettes and conventional 33 (15,7%), and never using both 125 (59,5%). The majority of respondents received information about e-cigarettes from their peers 150 (71,4%). The results of the bivariate analysis showed that age and sex were related to the e-cigarettes use among respondents with a p-value of 0,000.The number of cigarette use among adolescents continues to increase both conventional cigarettes and e-cigarettes, and the age of starting smoking is getting younger. This phenomenon should be a driving force for policymakers to be more intense in carrying out various tobacco control efforts