Use of denosumab in osteogenesis imperfecta: A case report

Maldonado, Génessis; Ferro, Christian; Paredes, Carlos; Ríos, Carlos

doi:10.1016/j.rcreu.2018.01.001

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…The philosophical-methodological basis of the study was the transfer interpretations of the Quantum Transition Theory in social sciences, presented in several scientific publications (Compagne, 2020;Goswami, 2013;Höne, 2017;Maldonado, 2019;Wendt & Mershon, 2014;Zohar, 1995;Zohar, 2021). The results of the theoretical studies collected by the authors, which were used in the preparation of the survey questionnaire to conduct the formative experiment, will follow.…”

Section: Philosophically Methodological Basis Of Research: Literature...mentioning

confidence: 99%

“…Other theories began to emerge around quantum physics, such as synergetic and chaos theories, which became the basis for new research in the social sciences and for extending the frontiers of quantum physics to the study of other sciences. This raises questions about the status and limits of the social sciences (Höne, 2017;Maldonado, 2019;Rigolot, 2020;Wendt & Mershon, 2014;Zohar, 1999;Zohar, 2021). The use of quantum theory ideas opens up new possibilities for social science content.…”

Section: Philosophically Methodological Basis Of Research: Literature...mentioning

confidence: 99%

“…The use of quantum theory ideas opens up new possibilities for social science content. Scientists also use the term 'quantum social science' (Höne, 2017;Lai, 2006;Maldonado, 2019).…”

Section: Philosophically Methodological Basis Of Research: Literature...mentioning

confidence: 99%

“…• application of quantum physics, including quantum theory transfers in social sciences, including personality psychology, to explain the ongoing changes in society, linking it to the beginning of a new phase in human development (Auzinsh et al, 2010;Compagne, 2020;Goswami, 2013;Haravijard, Yamani, & Gaulin, 2015;Lai, 2006;Maldonado, 2019;Scholz, Wessnigk, & Weber 2020). • new trends in the new generations of society (theories of generational development and transformation) (Dimock, 2019;Gomez, Mawhinney, & Betts, 2020;Meola, 2023;Potgieter, Ferreira, & Coetzee, 2019).…”

Section: Methodsmentioning

confidence: 99%

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Self-Assessment of Prospective Engineers’ Career Management in the Context of Quantum Transition Theory in Social Sciences

Baltusite,

Katane

2024

EID

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We live in a changing and complex world open for potential personal development. At the same time, the Earth is moving to a new level, from a 3-dimensional to a 5-dimensional level. This process is called the quantum transition. Nowadays career management theories are developing and changing under the influence of the quantum transition paradigm, thus the perception of career and the understanding of career have also changed. A career covers the whole life of a person and is individually driven. So, we can speak of a self-directed personal career, which is connected with finding one’s mission in life, one’s vocation. So, moving into the fourth and fifth dimensions opens up more possibilities for finding your purpose: 1) motivated individual choice; 2) career management based on that choice; 3) transition from survival to mission; 4) access to the information field of the Universe; 5) discovery of new abilities – telekinesis, teleportation, clairvoyance, clairaudience, etc. The article considers the notion of the quantum transition, career, career management and the characteristics of the Generation Z from the perspective of various authors. The analysis is carried out by assessing the data acquired on the specific features of the existent career management and the possibilities which provides the current situation for the engineers-to-be. The research aim is to study the specific features of the career management of the prospective engineers in the perspective of the quantum transition. The obtained high-level results testify that engineering students have sufficient employability potential, which largely indicates their competitiveness. The obtained low-level results indicate that the students are not yet ready to lifelong learn and develop professionally throughout his life, is not ready for changes in his chosen career, which indicates a certain inflexibility in thinking and acting. It is precisely these qualities that are very necessary in self-management of a sustainable career. This means that career support services should continue to be offered to promote career self-development and self-management under changing conditions (closely related to quantum transition theory). During the formative (pedagogical) experiment, significant and very significant changes occurred in students' self-assessments according to the following criteria: students' internal and external resources, competitiveness in the chosen profession (p value = 0.005 ... 0.018). This means that during the survey, the self-assessment of internal resources according to these indicators was influenced by the information obtained during the survey from the content of the questionnaire, which allowed for a more adequate self-assessment at the end of the experiment.

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Section: Philosophically Methodological Basis Of Research: Literature...mentioning

confidence: 99%

Section: Philosophically Methodological Basis Of Research: Literature...mentioning

confidence: 99%

“…The use of quantum theory ideas opens up new possibilities for social science content. Scientists also use the term 'quantum social science' (Höne, 2017;Lai, 2006;Maldonado, 2019).…”

Section: Philosophically Methodological Basis Of Research: Literature...mentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Self-Assessment of Prospective Engineers’ Career Management in the Context of Quantum Transition Theory in Social Sciences

Baltusite,

Katane

2024

EID

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“…La Osteogénesis imperfecta (OI) o "enfermedad de los huesos de cristal", es considerada una enfermedad rara con una incidencia de alrededor de 1 por cada 10 000 a 20 000 habitantes (Gimeno-Martos et al 2017;Maldonado et al 2018). Esto significa que, en el Ecuador, en donde existen alrededor de 350 000 nacimientos por año, nacerán cada año aproximadamente 30 niños con OI.…”

Section: Introductionunclassified

Osteogénesis imperfecta en adulto: un desafío en el manejo anestésico

Monar¹,

Lira²

2019

REMCB

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La incidencia de Osteogénesis Imperfecta (OI) es aproximadamente de 1 por cada 10 000a 20 000 habitantes. Es una enfermedad que en la mayoría de los casos es autosómica dominante y quese presenta cuando existen mutaciones en los genes que codifican al colágeno tipo I. La supervivenciade estos pacientes depende del grado de afección de la OI, existiendo casos que llegan a la adultez. Estebreve reporte presenta el manejo anestésico de una paciente con OI que fue solicitada para corrección deprolapso uterino con difícil acceso de la vía aérea y dificultad en el manejo ventilatorio por la deformidadde la caja torácica, realizándose intubación con video estilete y manejo de la ventilación con Volumen Tidalpara protección de pulmón con características restrictivas. El manejo anestésico se realizó con AnestesiaTotal Intravenosa (TIVA), utilizando infusión con propofol y remifentanilo y dosis única de rocuronio paraintubación con la finalidad de evitar utilizar medicamentos que puedan desencadenar hipertermia maligna.

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The Role of Denosumab and Bisphosphonate in Osteogenesis Imperfecta: A Literature Review

Kresnadi,

Wahyu Martanto,

Zulkarnain

et al. 2024

Salud, Ciencia y Tecnología

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Osteogenesis Imperfecta (OI) is a rare genetic disorder characterized by brittle bones and susceptibility to fractures. Management of OI focuses on minimizing fractures and improving bone strength. Denosumab and bisphosphonates have emerged as potential therapeutic agents in OI management due to their ability to modulate bone turnover. This literature review aims to explore the role of denosumab and bisphosphonates in the treatment of OI, highlighting their mechanisms of action, efficacy, and safety profiles. A comprehensive search was conducted across various databases, to identify relevant studies investigating the use of denosumab and bisphosphonates in OI management. The review discusses the molecular pathways underlying the pathogenesis of OI and how denosumab and bisphosphonates intervene in these pathways to improve bone quality. Furthermore, the review summarizes the findings from clinical trials and observational studies evaluating the effectiveness of denosumab and bisphosphonates in reducing fracture rates, improving bone mineral density, parathyroid hormone changes, calcium and phosphate quantity, and also enhancing functional outcomes in patients with OI. Additionally, considerations regarding optimal dosing, timing of initiation, and potential adverse effects of denosumab and bisphosphonates in individuals with OI are discussed. The synthesis of existing evidence underscores the promising role of denosumab and bisphosphonates as adjunctive therapies in the management of OI, although further research is warranted to elucidate their long-term efficacy and safety profiles in this patient population.

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Use of denosumab in osteogenesis imperfecta: A case report

Cited by 3 publications

References 7 publications

Self-Assessment of Prospective Engineers’ Career Management in the Context of Quantum Transition Theory in Social Sciences

Self-Assessment of Prospective Engineers’ Career Management in the Context of Quantum Transition Theory in Social Sciences

Osteogénesis imperfecta en adulto: un desafío en el manejo anestésico

The Role of Denosumab and Bisphosphonate in Osteogenesis Imperfecta: A Literature Review

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Use of denosumab in osteogenesis imperfecta: A case report

Cited by 3 publications

References 7 publications

Self-Assessment of Prospective Engineers’ Career Management in the Context of Quantum Transition Theory in Social Sciences

Self-Assessment of Prospective Engineers’ Career Management in the Context of Quantum Transition Theory in Social Sciences

Osteogénesis imperfecta en adulto: un desafí­o en el manejo anestésico

The Role of Denosumab and Bisphosphonate in Osteogenesis Imperfecta: A Literature Review

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Osteogénesis imperfecta en adulto: un desafío en el manejo anestésico