Use of capillary glucose combined with other non‐laboratory examinations to screen for diabetes and prediabetes

Abstract

Aim To evaluate the value and feasibility of capillary glucose assessment, combined with other non‐laboratory measures, in screening for diabetes and prediabetes in the community. Methods In this cross‐sectional study, we assessed fasting capillary glucose, fasting plasma glucose, and both capillary glucose and plasma glucose values after 2‐h oral glucose tolerance tests in a total of 3736 samples. We determined the optimal threshold of capillary glucose using receiver‐operating characteristic curve analysis. The effect of screening methods using capillary glucose combined with other variables, such as age, BMI and waist circumference, was assessed according to area under the receiver‐operating characteristic curve. Results There was a strong positive correlation between capillary glucose and venous plasma glucose. The area under the curve for the model using fasting capillary glucose to screen for impaired fasting glucose was 0.722, while that for the model using capillary glucose after a 2‐h oral glucose tolerance test to screen for impaired glucose tolerance was 0.916. The area under the curve for the model using fasting capillary glucose to screen for diabetes was 0.835, while that for the model using 2‐h oral glucose tolerance test capillary glucose was 0.912. The area under the curve for the model using fasting capillary glucose + 2‐h oral glucose tolerance test capillary glucose to screen for diabetes was 0.945. The discriminatory capability of models using capillary glucose was somewhat improved by adding non‐laboratory variables. Conclusions Capillary glucose could be an alternative for screening for diabetes and prediabetes, especially in low‐resource areas.

Prevalence and determinants of diabetes mellitus in high altitude: A cross sectional study in mountainous region of Nepal

“…Various studies done previously showed strong positive correlation between capillary glucose and venous plasma glucose 5 . Hence capillary glucose measurement can be used as alternative to venous glucose in resource limited situations for screening of diabetes mellitus 5 .…”

Self-administered oral glucose tolerance test with capillary glucose measurements for the screening of diabetes mellitus in high-risk adults: a feasibility study

“…The comparability between the cOGTT and vOGTT alludes to the former in identifying people with prediabetes or T2DM. [28][29][30][31][32] The higher mean capillary glucose values, compared with venous glucose values, potentially identify more people with suspected dysglycemia, while those with normal capillary glucose results are least likely to have wrong diagnosis of prediabetes or T2DM. The results suggest a possible two-tiered approach: those with abnormal capillary OGTT will proceed to the conventional OGTT for definitive diagnosis.…”

HbA1c combined with glycated albumin or 1,5‐anhydroglucitol improves the efficiency of diabetes screening in a Chinese population

“…At the same time, multiple blood collections may increase people's pain and decrease their compliance. In general, fasting plasma glucose (FPG) is more commonly used in diabetes screening, so randomised blood collection is not allowed, whereas most people suffering from diabetes in China present with isolated postprandial hyperglycaemia 4,5 …”

“…In general, fasting plasma glucose (FPG) is more commonly used in diabetes screening, so randomised blood collection is not allowed, whereas most people suffering from diabetes in China present with isolated postprandial hyperglycaemia. 4,5 Therefore, effective diagnosis is impossible for the majority of individuals who visit the clinic after eating, those who cannot manage long-term fasting or repeated blood drawing, and those with poor compliance. Consequently, there is a greater need for a sensitive, simple and effective method to detect diabetes randomly.…”