Use of Biobrane® to Dress Split-Thickness Skin Graft Adjacent to Skin Graft Donor Sites or Partial-Thickness Burns

Farroha, Azzam; Frew, Quentin; El-Muttardi, Naguib; Philp, Bruce; Dziewulski, Peter

doi:10.1097/bcr.0b013e3182779945

Cited by 13 publications

(10 citation statements)

References 3 publications

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“…It has the advantage of being a one-step procedure with permanent replacement of dermal and epidermal layers. However, no clinical trials have been reported yet [46,116,117,118,119,120]. Another full thickness skin substitute that is used in chronic therapy-resistant leg/foot ulcers is Tiscover™.…”

Section: Types Of Skin Substitutesmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

518

418

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Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly. There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable, and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application.

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Section: Types Of Skin Substitutesmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

518

418

View full text Add to dashboard Cite

show abstract

“…5 ) in many centres [ 68 – 70 ]. Biobrane® is the exact product of Transcyte® less the neonatal human fibroblasts and is also used as a dressing to hold meshed autografts and cultured keratinocyte suspension [ 69 , 71 ]. On top of the versatility in usage, the popularity of Biobrane® is likely due to its lower cost and yet, it is as efficacious in treating partial thickness burns compared to Transcyte® [ 72 ].…”

Section: Reviewmentioning

confidence: 99%

Skin tissue engineering advances in severe burns: review and therapeutic applications

et al. 2016

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Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium (within 3 to 4 weeks) helped alleviate the problem of insufficient donor site for extensive burn, many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn excision. Alternatives offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly successfully. Despite the availability of these commercial products, they all suffer from the same problems of extremely high cost, sub-normal skin microstructure and inconsistent engraftment, especially in full thickness burns. Clinical practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes, usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results long-term. This review seeks to bring the reader through the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.

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“…In a retrospective review, Biobrane ® promoted adherence of split thickness skin grafts to the wound, allowing fluid drainage and preventing shearing. Biobrane ® also facilitated healing of adjacent donor site or partial thickness burns [ 116 ].…”

Section: Skin Substitutes For Wound Healingmentioning

confidence: 99%