volume 267, issue 1-2, P151-156 2003
DOI: 10.1016/j.ijpharm.2003.08.005
View full text

Abstract: The internal structure of pharmaceutical solid dosage forms is commonly revealed by secondary electron imaging using standard scanning electron microscopy (SEM) technique. In this work we propose a back-scattered electron imaging (BEI) as a new tool for examining the matrix structure of calcium pectinate beads. Imaging samples with back-scattered electrons in the SEM is based on material or atomic number contrast. High atomic number elements, such as calcium, reflect more electrons and appear bright on electro…

expand abstract