Use of autologous platelet-rich fibrin on hard-to-heal wounds

Steenvoorde, Pascal; Doorn, Louk P. van; Naves, Cleiton Dias; Oskam, Jacques

doi:10.12968/jowc.2008.17.2.28179

Cited by 59 publications

(57 citation statements)

References 9 publications

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“…On the other hand, it may be worthwhile exploring further the use of PRF in the treatment of chronic wounds. 45 Finally, we have demonstrated, for the first time in man that subcutaneous collagen deposition in ePTFE tubes reflects breaking strength of adjacent primary closed skin wounds.…”

Section: Discussionmentioning

confidence: 73%

Platelet-Rich Fibrin Versus Albumin in Surgical Wound Repair

2010

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Section: Discussionmentioning

confidence: 73%

Platelet-Rich Fibrin Versus Albumin in Surgical Wound Repair

2010

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“…Then Group A was administered PRP and for Group B L-PRF gel was applied. 4,5 The technique was repeated weekly once for 6 weeks. The results were monitored every week through percentage reduction in area and volume of ulcers.…”

Section: Methodsmentioning

confidence: 99%

Autologous Platelet Rich Plasma (Prp) Versus Leucocyte-Platelet Rich Fibrin (L-Prf) in Chronic Non-Healing Leg Ulcers - A Randomised, Open Labelled, Comparative Study

Pravin¹,

Sridhar²,

Srinivasan³

2016

jemds

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BACKGROUNDOur aim was to evaluate and compare the efficacy of Platelet-Rich Plasma (PRP) and Leucocyte Platelet Rich Fibrin (L-PRF) in the treatment of chronic non-healing leg ulcers. MATERIALS AND METHODSA randomised, open labelled comparative study was performed on 30 patients with non-healing ulcers of various aetiologies. 15 patients were treated with PRP and 15 patients with L-PRF at weekly intervals for a maximum of 6 treatments. At the end of the 6-week period, reduction in size of the ulcers (Area and volume) was assessed. RESULTSOf 30 ulcers, there were 22 venous ulcers, 1 ulcer due to vasculitis, 1 traumatic ulcer, 2 diabetic ulcers and 4 trophic ulcers. The mean duration of healing of the ulcers were 5.7 weeks in L-PRF and 6.5 in PRP (p = 0.034). About 100% resolution was seen in 11 of the ulcers in L-PRF and 8 of the ulcers in PRP at the end of the 6th treatment (73.3% vs. 53.3%).CONCLUSION L-PRF is more efficacious and has a quicker healing rate than PRP, probably due to its anti-inflammatory effects and also protection against infections. L-PRP will be more promising in future than PRP in treating chronic ulcers.

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“…Means for platelet count, 255·4 K (normal range 150-350), albumin, 3·2 g/dl (normal range 3·5-5·0), and pre-albumin, 24·4 g/dl (normal range [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35], were within normal ranges. However, means for haemoglobin of 11·4 g/dL (normal range for males [13][14][15][16][17][18] and for haematocrit of 34·6% (normal range for males 45-62) were below normal.…”

Section: Resultsmentioning

confidence: 99%

Effect of platelet rich plasma gel in a physiologically relevant platelet concentration on wounds in persons with spinal cord injury

Rappl¹

2011

International Wound Journal

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The objective of the study was to investigate the use of a 1·3 times normal platelet concentration platelet-rich plasma (PRP) gel to move chronic wounds towards healing in persons with spinal cord injury (SCI). The study design was a case series of 20 persons with SCI with non healing wounds. The outcome measures were, in wound area, volume, undermining and sinus tracts/tunnels (ST/Ts), calculated average, (i) percent of change from baseline, (ii) change per day from baseline, (iii) number of treatments and (iv) number of weeks. In a mean of 4·0, after treatments over 3·4 weeks, the wounds closed on an average of 47·9% in area and 56·0% in volume. Undermining closed on an average of 31·4% using 3·5 treatments over 2·6 weeks. ST/Ts closed on an average of 26·1% after 2·3 treatments over 1·5 weeks. Clinical relevance by percent of positive responders and their response: in area, 90·0% of the subjects responded positively, the average reduction was 53·8%. In volume, 90·0% responded, with an average reduction of 67·3%. Of four subjects with undermining, 75% closed 47·0% on average. Of the three with ST/Ts, 100% closed 26·1% on average. Average haemoglobin and haematocrit levels were below normal. To conclude, 1·3× PRP gel appears to progress chronic, non healing wounds in SCI patients into the granulation phase of healing quickly. Review of the literature shows these results may not be applied to all PRP preparations.

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Use of autologous platelet-rich fibrin on hard-to-heal wounds

Abstract: This retrospective study found that use of autologous platelet-rich fibrin on a range of hard-to-heal wounds achieved full healing or a significant reduction in wound diameter with no adverse effects. Prospective studies are now needed

Cited by 59 publications

References 9 publications

Platelet-Rich Fibrin Versus Albumin in Surgical Wound Repair

Platelet-Rich Fibrin Versus Albumin in Surgical Wound Repair

Autologous Platelet Rich Plasma (Prp) Versus Leucocyte-Platelet Rich Fibrin (L-Prf) in Chronic Non-Healing Leg Ulcers - A Randomised, Open Labelled, Comparative Study

Effect of platelet rich plasma gel in a physiologically relevant platelet concentration on wounds in persons with spinal cord injury

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