Use of Antipsychotics to Treat Cocaine Toxicity?

Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

“…Ziprasidone, an antagonist at dopamine and serotonin receptors, reduces cocaine induced lethality in pretreated mice by 51% (Cleveland et al, 2005), although in a more recent investigation using similar doses, ziprasidone failed to prevent lethality but did delay the onset of seizure (Cleveland et al, 2007). There are concerns whether antipsychotics should be used at all in the setting of cocaine toxicity (Wu et al, 2008). Conflicting data exist regarding antipsychotics that may be agent and or species specific.…”