Use of a bioresource nanocomposite as a heterogeneous base catalyst for the green synthesis of novel bioactive pyrazoles: antibacterial evaluation using molecular docking

Abstract

Synthesis and molecular docking of pyrazole derivatives using the heterogeneous basic, CS-DAA/MgO nanocomposite.

One-Pot Synthesis of 1,3,5-Trisubstitued Pyrazoles via Immobilized Thermomyces lanuginosus Lipase (TLL) on a Metal–Organic Framework

“…Pyrazoles are five-membered rings containing two adjacent nitrogens, which are present in the structure of many drugs such as celecoxib, lonazolac, difenamizole, SC-560, and CDPPB − (Figure ). Pyrazoles, due to their biological and pharmacological activities such as antifungal, antiviral, anticancer, antioxidant, antibacterial, and anti-inflammatory, have been the subject of many studies. − Due to the high importance of pyrazole in the pharmaceutical industry, providing green synthetic methods for pyrazole has always been of interest. − …”

“… 7 − 11 Due to the high importance of pyrazole in the pharmaceutical industry, providing green synthetic methods for pyrazole has always been of interest. 12 − 14 …”