Use of 660-nm Diode Laser in the Prevention and Treatment of Human Oral Mucositis Induced by Radiotherapy and Chemotherapy

Zanin, Taís; Zanin, Fátima A. A.; Carvalhosa, Artur Aburad de; Castro, Paulo Henrique de Souza; Pacheco, Marcos Tadeu Tavares; Zanin, Iriana Carla Junqueira; Brugnera, Aldo

doi:10.1089/pho.2008.2242

Cited by 67 publications

(62 citation statements)

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“…LPT is based on nonthermal effects of light on biological tissues, and its use in the prevention and treatment of mucositis induced by antineoplastic treatment has presented promising results, especially in clinical studies (1,3,4,13). The effect of LPT is based on its ability to modulate several metabolic processes.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, Zanin et al (1) and Lopes et al (17) reported that in their studies all patients under RT who received LPT completed the planned RT treatment, whereas patients not treated with LPT had to interrupt the RT because of decreased immunity caused by secondary asthenia and deglutition difficulties, which impacted their survival. Several protocols have been used for treating oral mucositis and the observed results sometimes differ (1,3,4,13,16,17). It is necessary to standardize the protocols for prevention and treatment of this condition in order to make different studies comparable.…”

Section: Discussionmentioning

confidence: 99%

“…Oral mucositis may result from irradiation that induces the death of the basal cells of the mucosal epithelium, usually two weeks after the beginning of radiotherapy (RT) (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Discomfort or severe oral pain may be caused by oral mucositis, as well as difficulties on drinking, eating, swallowing and speaking, which impair patient's quality of life (1,3). It starts asymptomatic, later on, an erythema appears and it may be followed by erosion or ulceration of the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

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Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Lino

Carvalho

Oliveira³

et al. 2011

Braz. Dent. J.

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Oral mucositis is a harmful side effect of radiotherapy (RT) on the head and neck region. There are encouraging reports on the beneficial aspects of the use of laser light on the treatment of oral mucositis. This paper reports the efficacy of laser phototherapy (LPT) on the treatment of oral mucositis in a patient undergoing RT after surgical removal of a squamous cell carcinoma with osseous invasion of the maxilla. Palatal and commissural lesions were treated with l660 nm, 40 mW, ∅=4 mm 2 , in contact mode, 5 x 2.4 J/cm 2 per point, 14.4 J/cm 2 per session. For treating the lesion on the patient's nasal mucosa, LPT (∅=4 mm 2 , l780 nm, 70 mW, 3 x 2.1 J/cm 2 per point, 6.3 J/cm 2 per session, contact mode) was used on the external area of the nose. A single dose (2.4 J/cm 2 ) with the l660 nm laser, as described before, was applied on the entrance of each nostril. LPT was used 3 times/week during 4 weeks. Treatment results indicate that the use of LPT on oral mucositis was effective and allowed the patient to carry on the RT without interruption. However, long-term and controlled clinical trials are necessary to establish both preventive and curative protocols using LPT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Oral mucositis may result from irradiation that induces the death of the basal cells of the mucosal epithelium, usually two weeks after the beginning of radiotherapy (RT) (1,2).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Lino

Carvalho

Oliveira³

et al. 2011

Braz. Dent. J.

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“…Ils rapportent un meilleur contrôle de l'intensité de la douleur avec le laser de plus faible énergie avec un protocole de 3 fois/semaine. Zanin et al (2009) ont obtenu des résultats similaires avec un laser diode 660 nm utilisé 2 fois/semaine, dans une étude portant sur 72 patients (groupe laser versus groupe contrôle (n = 36)) [16].…”

Section: Commentairesunclassified

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

Lescaille

Lang

Ernenwein

et al. 2010

Med Buccale Chir Buccale

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Mots clés : mucite buccale / laser / douleur / cancers des voies aéro-digestivesRésumé -La mucite est une complication classique de la radiothérapie et/ou de la chimiothérapie dans le traitement des cancers des voies aéro-digestives supérieures. Sa prise en charge est avant tout symptomatique : prescription d'un traitement antalgique, topique et systémique. Depuis quelques années, l'utilisation de différents lasers s'est révélée particulièrement intéressante pour le traitement préventif et curatif des mucites radio et/ou chimio-induites. L'objectif de cet article est de faire le point sur les mécanismes d'action du laser de basse énergie et ses indications dans le traitement de lésions muqueuses spécifiques. Nous rapportons ici l'exemple d'un cas de mucite de grade 3 radio-induite chez un patient en cours de radiothérapie postopératoire pour un carcinome épidermoïde du rebord maxillaire. La prise en charge classique (soins locaux et antalgiques) a été mise en place, en association avec des séances de laser Nd :YAP (1,34 μm). Le retour à une toxicité muqueuse ≤ 2 et une cicatrisation de la plupart des zones ulcérées ont été observés dès la première semaine d'application. Parallèlement, un effet antalgique rapide était constaté avec une diminution de la douleur qui est passée de 90 à 30 sur l'EVA.Key words: oral mucositis / laser / pain / head and neck cancers Abstract -Lasers in the treatment of oral mucositis. Report of a case and review of littérature. The mucositis is a common complication of radiotherapy and/or chemotherapy in the treatment of head and neck cancers. Its management is symptomatic with topical and systemic analgesics. In recent years, the use of various lasers has proved particularly interesting for the preventive and curative treatment of mucositis induced by radiotherapy and chemotherapy. The aim of this article is to review the mechanisms of action of low energy laser and its indications in the treatment of mucosal lesion. We report here the case of mucositis grade 3 radiation-induced in a patient during postoperative radiotherapy for squamous cell carcinoma of the maxillary. Classical treatment (local care and analgesics) was set up in conjunction with sessions of Nd:YAP (1.34 mm). The return to ≤ 2 mucosal toxicity and scarring of the ulcerated areas were most observed in the first week of application. Meanwhile a rapid analgesic effect was observed with a decrease in pain that went from 90-30 on the VAS.La radiothérapie, exclusive ou postopératoire, occupe une place fondamentale dans le traitement des cancers des voies aéro-digestives supérieures. Dans les formes avancées, le bé-néfice d'une chimiothérapie concomitante à l'irradiation a été clairement démontré : elle permet d'améliorer le contrôle local

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Interventions for preventing oral mucositis for patients with cancer receiving treatment

Worthington

Clarkson

Bryan

et al. 2010

Cochrane Database of Systematic Reviews

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BackgroundTreatment of cancer is increasingly more effective but is associated with short and long term side effects. Oral side effects remain a major source of illness despite the use of a variety of agents to prevent them. One of these side effects is oral mucositis (mouth ulcers). ObjectivesTo evaluate the effectiveness of prophylactic agents for oral mucositis in patients with cancer receiving treatment, compared with other potentially active interventions, placebo or no treatment.

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Use of 660-nm Diode Laser in the Prevention and Treatment of Human Oral Mucositis Induced by Radiotherapy and Chemotherapy

Abstract: Laser therapy was effective in preventing and treating oral effects induced by radiotherapy and chemotherapy, thus improving the patient's quality of life.

Cited by 67 publications

References 12 publications

Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

Interventions for preventing oral mucositis for patients with cancer receiving treatment

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