Use of 1H NMR in the identification of a metabolite of a catecholic cephalosporin excreted in rat bile

Effective on-line purification for cationic compounds in rat bile using a column-switching LC technique

“…On the other hand, several studies have addressed the analysis of drugs in bile by using liquid chromatographyinductively coupled argon plasma mass spectrometry (LC-ICP/MS) [5][6][7], LC-nuclear magnetic resonance (LC/NMR) [8] and LC-mass spectrometry (LC/MS) [9,10]. These study evaluated the stability of a target drug and structural analysis of metabolites in bile without radioactive samples.…”