US-triggered Microbubble Destruction for Augmenting Hepatocellular                    Carcinoma Response to Transarterial Radioembolization: A Randomized Pilot                    Clinical Trial

Eisenbrey, John R.; Forsberg, Flemming; Wessner, Corinne E.; Delaney, Lauren J; Bradigan, Kristen; Gummadi, Sriharsha; Tantawi, Mohamed; Lyshchik, Andrej; O’Kane, Patrick; Liu, Ji‐Bin; Intenzo, Charles; Civan, Jesse; Maley, Warren R.; Keith, Scott W.; Anton, Kevin; Tan, Allison; Smolock, Amanda R.; Shamimi-Noori, Susan; Shaw, Colette M.

doi:10.1148/radiol.2020202321

Cited by 53 publications

(40 citation statements)

References 25 publications

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“…Tumour response was evaluated in both groups. Results indicated greater tumour response to TARE + USMB treatment in participants compared to TARE treatment alone [ 69 ]. In this case, TARE is not purely radiation but an embolic treatment that also causes vascular destruction by blocking blood flow.…”

Section: Clinical Relevance Of Usmb and Ceramidementioning

confidence: 99%

“…Currently, research has focused on USMB treatment-enhancing properties in drug delivery and radiotherapy. Although most studies conducted are preclinical, a number of clinical studies have been carried out in order to determine the safety of USMB therapy in patients with different diseases [ 66 , 67 , 68 , 69 , 70 ]. USMB combined with chemotherapy and or XRT has been explored extensively in preclinical models and has succeeded in exhibiting fruitful outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy

Sharma

Czarnota

2022

IJMS

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Sphingolipids are well-recognized critical components in several biological processes. Ceramides constitute a class of sphingolipid metabolites that are involved in important signal transduction pathways that play key roles in determining the fate of cells to survive or die. Ceramide accumulated in cells causes apoptosis; however, ceramide metabolized to sphingosine promotes cell survival and angiogenesis. Studies suggest that vascular-targeted therapies increase endothelial cell ceramide resulting in apoptosis that leads to tumour cure. Specifically, ultrasound-stimulated microbubbles (USMB) used as vascular disrupting agents can perturb endothelial cells, eliciting acid sphingomyelinase (ASMase) activation accompanied by ceramide release. This phenomenon results in endothelial cell death and vascular collapse and is synergistic with other antitumour treatments such as radiation. In contrast, blocking the generation of ceramide using multiple approaches, including the conversion of ceramide to sphingosine-1-phosphate (S1P), abrogates this process. The ceramide-based cell survival “rheostat” between these opposing signalling metabolites is essential in the mechanotransductive vascular targeting following USMB treatment. In this review, we aim to summarize the past and latest findings on ceramide-based vascular-targeted strategies, including novel mechanotransductive methodologies.

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Section: Clinical Relevance Of Usmb and Ceramidementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy

Sharma

Czarnota

2022

IJMS

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“…36 As part of an ongoing clinical trial, CEUS is being tested as an early way of evaluating HCC response to TARE. 37 Preliminary results have showed that reduction in tumor vascularity quantified by CEUS was associated with better mRECIST response categories and attributed to destruction of tumor vasculautre. 38 These results align with prior studies using pretreatment computed tomography perfusion imaging parameters to predict HCC response to TARE.…”

Section: D Ceus In Lrt Response Monitoringmentioning

confidence: 99%

State of the Art: Contrast Enhanced 4D Ultrasound to Monitor or Assess Locoregional Therapies

Tantawi

Shamimi-Noori

Shaw

et al. 2022

Digestive Disease Interventions

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Locoregional therapies (LRTs) are an essential management tool in the treatment of primary liver cancers or metastatic liver disease. LRTs include curative and palliative modalities. Monitoring treatment response of LRTs is crucial for maximizing benefit and improving clinical outcomes. Clinical use of contrast-enhanced ultrasound (CEUS) was introduced more than two decades ago. Its portability, cost effectiveness, lack of contraindications and safety make it an ideal tool for treatment monitoring in numerous situations. Two-dimensional dynamic CEUS has been proved to be equivalent to the current imaging standard in the guidance of LRTs, assessment of their adequacy, and detection of early tumor recurrence. Recent technical advances in ultrasound transducers and image processing have made 3D CEUS scanning widely available on most commercial ultrasound systems. 3D scanning offers a broad multiplanar view of anatomic structures, overcoming many limitations of two-dimensional scanning. Furthermore, many ultrasound systems provide real-time dynamic 3D CEUS, also known as 4D CEUS. Volumetric CEUS has shown to perform better than 2D CEUS in the assessment and monitoring of some LRTs. CEUS presents a valid alternative to the current imaging standards with reduced cost and decreased risk of complications. Future efforts will be directed toward refining the utility of 4D CEUS through approaches such as multi-parametric quantitative analysis and machine learning algorithms.

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“…Moreover, the treatment increased patient tolerance to the increased number of gemcitabine cycles, decreased the maximum tumor diameter (in five patients), and enhanced the median survival of patients from 8.9 to 17.6 months. Through a different cancer treatment approach, a study with 28 participants demonstrated the feasibility, safety, and efficacy of combining US-triggered MB destruction with hepatocellular carcinoma radioembolization [ 641 ]. There was a greater prevalence of tumor response in the patients who received this treatment while their liver function was preserved.…”

Section: Reviewmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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US-triggered Microbubble Destruction for Augmenting Hepatocellular Carcinoma Response to Transarterial Radioembolization: A Randomized Pilot Clinical Trial

Cited by 53 publications

References 25 publications

Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy

Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy

State of the Art: Contrast Enhanced 4D Ultrasound to Monitor or Assess Locoregional Therapies

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

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