Urticaria multiforme in a child with SARS-CoV-2 infection

Zawadka, Konrad; Ołdakowska, Agnieszka

doi:10.4081/dr.2021.9159

Cited by 3 publications

(3 citation statements)

References 8 publications

(20 reference statements)

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“…Likewise, in a systematic review of 899 patients with COVID-19, 83 (7.9%) had urticarial lesions along COVID-19 and 17 (16%) had urticaria before the onset of COVID-19 symptoms [ 53 , 56 ]. In one study, among other cutaneous manifestations, urticaria manifested with the highest D-dimer levels in COVID-19 patients [ 54 , 55 , 57 , 58 ]. Additionally, an analysis of 200 COVID-19 patients with cutaneous manifestations found a significant association between urticaria and gastrointestinal symptoms [ 56 , 59 ].…”

Section: The Role Of Viral Infections Including Covid-19 In Causing A...mentioning

confidence: 99%

“…A correlation between urticaria and the severity of COVID-19 has not been established; however, its occurrence appears not to worsen the prognosis [ 57 , 60 ]. Urticaria multiforme and urticarial vasculitis have also been described in association with COVID-19 [ 58 , 59 , 61 , 62 ].…”

Section: The Role Of Viral Infections Including Covid-19 In Causing A...mentioning

confidence: 99%

“…A multicenter study that evaluated the duration of cutaneous manifestations of COVID-19 in long-haulers (=long covid: patients with dermatological signs of COVID-19 that persisted for more than 60 days) revealed that urticarial eruptions lasted a median of 4 days with a maximum duration of 28 days [ 61 , 64 ]. However, the onset of was also described several weeks after COVID-19 symptoms [ 55 , 57 , 58 , 60 ].…”

Section: The Role Of Viral Infections Including Covid-19 In Causing A...mentioning

confidence: 99%

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How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Kocatürk

Muñoz

Elieh‐Ali‐Komi

et al. 2023

Viruses

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Since more than a century ago, there has been awareness of the connection between viral infections and the onset and exacerbation of urticaria. Our knowledge about the role of viral infection and vaccination in acute and chronic urticaria improved as a result of the COVID-19 pandemic but it has also highlighted knowledge gaps. Viral infections, especially respiratory tract infections like COVID-19, can trigger the onset of acute urticaria (AU) and the exacerbation of chronic urticaria (CU). Less frequently, vaccination against viruses including SARS-CoV-2 can also lead to new onset urticaria as well as worsening of CU in minority. Here, with a particular focus on COVID-19, we review what is known about the role of viral infections and vaccinations as triggers and causes of acute and chronic urticaria. We also discuss possible mechanistic pathways and outline the unmet needs in our knowledge. Although the underlying mechanisms are not clearly understood, it is believed that viral signals, medications, and stress can activate skin mast cells (MCs). Further studies are needed to fully understand the relevance of viral infections and vaccinations in acute and chronic urticaria and to better clarify causal pathways.

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Section: The Role Of Viral Infections Including Covid-19 In Causing A...mentioning

confidence: 99%

Section: The Role Of Viral Infections Including Covid-19 In Causing A...mentioning

confidence: 99%

Section: The Role Of Viral Infections Including Covid-19 In Causing A...mentioning

confidence: 99%

See 1 more Smart Citation

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Kocatürk

Muñoz

Elieh‐Ali‐Komi

et al. 2023

Viruses

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Epidemiology and clinical evolution of non-multisystem inflammatory syndrome (MIS-C) dermatological lesions in pediatric patients affected by SARS-CoV-2 infection: A systematic review of the literature

et al. 2022

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COVID-19 can present with a range of skin manifestations, some of which specific of the pediatric age. The aim of this systematic literature review was to determine the type, prevalence, time of onset, and evolution of cutaneous manifestations associated with COVID-19 in newborns, children, and adolescents, after excluding multisystem inflammatory syndrome in children (MIS-C). PubMed, Tripdatabase, ClinicalTrials, and Cochrane Library databases were searched using an ad hoc string for case reports/series and observational studies, published between December 2019 and February 2022. Study quality was assessed using the STROBE and CARE tools. Seventy-three (49 case reports/series and 24 studies) out of 26,545 identified articles were included in the analysis. Dermatological lesions were highly heterogeneous for clinical presentation, time of onset, and association with other COVID-19 manifestations. Overall, they mainly affected the acral portions, and typically presented a favorable outcome. Pseudo-chilblains were the most common. Conclusions : Mucocutaneous manifestations could be the only/predominant and early manifestation of COVID-19 that could precede other more severe manifestations by days or weeks. Therefore, physicians of all disciplines should be familiar with them. What is Known: • A variety of cutaneous manifestations have been reported in association with COVID-19. • Urticaria, maculopapular, or vesicular rashes can occur at any age, while chilblains and erythema multiforme are more common in children and young patients. What is New: • Skin lesions related to SARS-CoV-2 infection often show a peculiar acral distribution. • Mucocutaneous lesions of various type may be the only/predominant manifestation of COVID-19; they could present in paucisymptomatic and severely ill patients and occur at different stages of the disease. Supplementary Information The online version contains supplementary material available at 10.1007/s00431-022-04585-7.

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Urticaria multiforme in Asian children

Kan,

Koh,

Wee

2024

J Paediatrics Child Health

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AimUrticaria multiforme is an uncommon presentation of acute urticaria. It most commonly affects children and most often occurs secondary to an underlying viral infection. We performed a retrospective review of a cohort of Asian children with urticaria multiforme and reviewed the literature on the condition.MethodsWe retrospectively reviewed the clinical notes of children and adolescents less than 16 years of age, diagnosed with urticaria multiforme at our tertiary paediatric hospital between January 2017 and December 2022. Data collected and analysed included age, gender, initial diagnosis, antecedent symptoms, recent immunisations and medications, results of diagnostic tests, treatment and outcome.ResultsA total of 20 children were identified, with median age of diagnosis of 1.9 years, with most patients (79%) 7 years of age or younger. Viral infections were the commonest triggers. The most common referring diagnoses were erythema multiforme and Stevens–Johnson syndrome. Common antecedent or concomitant symptoms were fever and upper respiratory symptoms. Blood investigations were generally unremarkable except for mildly increased white cell counts and other markers of infection. Outcomes were good in all patients, with resolution of symptoms within 6 weeks without sequelae.ConclusionUrticaria multiforme is an uncommon presentation of acute urticaria. Despite its striking appearance, it is generally a benign, self‐limiting condition. Extensive investigations are usually not required and management is largely supportive.

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Urticaria multiforme in a child with SARS-CoV-2 infection

Cited by 3 publications

References 8 publications

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Epidemiology and clinical evolution of non-multisystem inflammatory syndrome (MIS-C) dermatological lesions in pediatric patients affected by SARS-CoV-2 infection: A systematic review of the literature

Urticaria multiforme in Asian children

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