Urticaria and anaphylactoid reactions after topical application of mechlorethamine

IgE antibody‐mediated shock reaction caused by topical application of chlorhexidine

“…In general, topical application of agents rarely induces anaphylactic reactions [13,14]. Our study, we believe, is the first to demonstrate a specific skin-sensitizing antibody in vivo by a passive transfer test, and to detect anti-chlorhexidine IgE antibodies in vitro by RAST assay.…”

IgE antibody‐mediated shock reaction caused by topical application of chlorhexidine

“…In general, topical application of agents rarely induces anaphylactic reactions [13,14]. Our study, we believe, is the first to demonstrate a specific skin-sensitizing antibody in vivo by a passive transfer test, and to detect anti-chlorhexidine IgE antibodies in vitro by RAST assay.…”

Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review

“…Similarly, a retrospective cohort analysis of 203 MF patients treated with topical nitrogen mustard reported no serious adverse events; side effects were mainly skin-limited [ 30 ]. Immediate hypersensitivity reactions to topical MCH have been reported but appear to be exceedingly rare [ 31 – 33 ]; treatment discontinuation is recommended in these cases. If patients experience symptoms of anaphylaxis, urgent medical evaluation is warranted.…”

Contact urticaria and anaphylactoid reaction induced by topical application of nitrogen mustard

“…However, topical administration of drugs may also result in immediate type reactions. Anaphylactoid reactions after topical treatment may occur after a patient has developed delayed hypersensitivity to a drug (Pippen, 1966) or without signs of previous contact dermatitis (Comaish & Cunliffe, 1967;Roupe & Strannegaard, 1969;Daughters et al 1973).…”

IgE antibody‐mediated shock reaction caused by topical application of chlorhexidine

“…In general, topical application of agents rarely induces anaphylactic reactions [13,14]. Our study, we believe, is the first to demonstrate a specific skin-sensitizing antibody in vivo by a passive transfer test, and to detect anti-chlorhexidine IgE antibodies in vitro by RAST assay.…”

Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review

“…Similarly, a retrospective cohort analysis of 203 MF patients treated with topical nitrogen mustard reported no serious adverse events; side effects were mainly skin-limited [ 30 ]. Immediate hypersensitivity reactions to topical MCH have been reported but appear to be exceedingly rare [ 31 – 33 ]; treatment discontinuation is recommended in these cases. If patients experience symptoms of anaphylaxis, urgent medical evaluation is warranted.…”

Contact urticaria and anaphylactoid reaction induced by topical application of nitrogen mustard

“…However, topical administration of drugs may also result in immediate type reactions. Anaphylactoid reactions after topical treatment may occur after a patient has developed delayed hypersensitivity to a drug (Pippen, 1966) or without signs of previous contact dermatitis (Comaish & Cunliffe, 1967;Roupe & Strannegaard, 1969;Daughters et al 1973).…”

IgE antibody‐mediated shock reaction caused by topical application of chlorhexidine

“…In general, topical application of agents rarely induces anaphylactic reactions [13,14]. Our study, we believe, is the first to demonstrate a specific skin-sensitizing antibody in vivo by a passive transfer test, and to detect anti-chlorhexidine IgE antibodies in vitro by RAST assay.…”

Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review

“…Similarly, a retrospective cohort analysis of 203 MF patients treated with topical nitrogen mustard reported no serious adverse events; side effects were mainly skin-limited [ 30 ]. Immediate hypersensitivity reactions to topical MCH have been reported but appear to be exceedingly rare [ 31 – 33 ]; treatment discontinuation is recommended in these cases. If patients experience symptoms of anaphylaxis, urgent medical evaluation is warranted.…”

Contact urticaria and anaphylactoid reaction induced by topical application of nitrogen mustard

“…However, topical administration of drugs may also result in immediate type reactions. Anaphylactoid reactions after topical treatment may occur after a patient has developed delayed hypersensitivity to a drug (Pippen, 1966) or without signs of previous contact dermatitis (Comaish & Cunliffe, 1967;Roupe & Strannegaard, 1969;Daughters et al 1973).…”