Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications

Iqbal, Javed; Abbasi, Banzeer Ahsan; Ahmad, Riaz; Mahmood, Tariq; Kanwal, Sobia; Ali, Barkat; Khalil, Ali Talha; Shah, Sayed Afzal; Alam, Muhammad Maqsood; Badshah, Hussain

doi:10.1016/j.biopha.2018.09.096

Cited by 97 publications

(60 citation statements)

References 46 publications

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“…Results were examined in the range of 200 − l μg/ml. According to American Society, biological substances showing % hemolysis of >5% is known as hemolytic, between 2–5% are slightly hemolytic, while <2% is non‐hemolytic . In this regard, NiONPs are non‐hemolytic at lower concentrations (< 5 μg/ml), while highest hemolysis (28.23%) was reported at the concentration of 200 μg/ml.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the phytocompounds in aqueous environment replace chemical reagents and organic/inorganic solvents . Currently, plant extracts of various parts (such as flower, fruit, seed powder, leaf, peel, bark) have been used for the formation of NPs . Plant extracts have medicinal values due to presence of different phytocompounds such as alkaloids, flavonoids, terpenoids, polyphenols, amino acids and vitamins …”

Section: Introductionmentioning

confidence: 99%

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Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Iqbal

Abbasi

Mahmood

et al. 2019

Applied Organom Chemis

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135

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In the present report, Nickel oxide nanoparticles (NiONPs) were synthesized using Rhamnus virgata (Roxb.) (Family: Rhamnaceae) as a potential stabilizing, reducing and chelating agent. The formation, morphology, structure and other physicochemical properties of resulting NiONPs were characterized by Ultra violet spectroscopy, X-ray diffraction (XRD), Fourier Transform Infrared analysis (FTIR), Scanning electron microscopy (SEM), Energy-dispersivespectroscopy (EDS), Transmission electron microscopy (TEM), Raman spectroscopy and dynamic light scattering (DLS). Detailed in vitro biological activities revealed significant therapeutic potential for NiONPs. The antimicrobial efficacy of biogenic NiONPs was demonstrated against five different gram positive and gram negative bacterial strains. Klebsiella pneumoniae and Pseudomonas aeruginosa (MIC: 125 μg/mL) were found to be the least susceptible and Bacillus subtilis (MIC: 31.25 μg/mL) was found to be the most susceptible strain to NiONPs. Biogenic NiONPs were reported to be highly potent against HepG2 cells (IC 50 : 29.68 μg/ml). Moderate antileishmanial activity against Leishmania tropica (KMH 23 ) promastigotes (IC 50 : 10.62 μg/ml) and amastigotes (IC 50 : 27.58 μg/ml) cultures are reported. The cytotoxic activity was studied using brine shrimps and their IC 50 value was recorded as 43.73 μg/ml. For toxicological assessment, NiONPs were found compatible towards human RBCs (IC 50 : > 200 μg/ml) and macrophages (IC 50 : > 200 μg/ml), deeming particles safe for various applications in nanomedicines. Moderate antioxidant activities: total antioxidant capacity (TAC) (51.43%), 2,2-diphenyl-1-picrylhydrazyl (DPPH) activity (70.36%) and total reducing power (TRP) (45%) are reported for NiONPs. In addition, protein kinase and alpha amylase inhibition assays were also performed. Our results concluded that Rhamnus virgata synthesized NiONPs could find important biomedical applications with low cytotoxicity to normal cells.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Iqbal

Abbasi

Mahmood

et al. 2019

Applied Organom Chemis

Self Cite

135

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“…It mainly induced apoptosis in HL-60 leukemia cells accompanied by mediating the release of intracellular calcium ions [39], inhibiting DNA synthesis [40] and blocking the cell cycle process [39,41], and inducing Atg5-dependent autophagy [42] and mitochondria dependent apoptosis [19] which supports the findings of the present study. Moreover, many reviews described the mode of action of ursolic acid in the control of cancer cells [18][19][20][21].…”

Section: Antiproliferative Activitymentioning

confidence: 99%

“…However, there is no data available on the antioxidant and antiproliferative properties of the isolated compound thujone (from Elaeagnus indica). Even though anticancer and antiproliferative activity of ursolic acid (isolated from Memecylon edule) were reported [18][19][20][21], there is no data available on growth inhibitory effect of ursolic acid on the human leukemic monocyte lymphoma (U-937) cells, and antioxidant potential of ursolic acid was the least explored. Moreover, there are no previous studies available on the in silico inhibition interactions of thujone and ursolic acid with topoisomerase II in detail.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Ramalingam

Arumugam²,

Lee

et al. 2020

BioMed Research International

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The present study aimed to evaluate the antioxidant and antiproliferative potential of ursolic acid and thujone isolated from leaves of Elaeagnus indica and Memecylon edule and their inhibitory effect on topoisomerase II using molecular docking study. The isolated ursolic acid and thujone were examined for different types of free radicals scavenging activity, the antiproliferative potential on U-937 and HT-60 cell lines by adopting standard methods. Further, these compounds were docked with the active site of the ATPase region of topoisomerase II. The findings of the research revealed that ursolic acid harbor strong antioxidant and antiproliferative capacity with low IC50 values than the thujone in all tested methods. Moreover, ursolic acid shows significant inhibition effect on topoisomerase II with a considerable docking score (−8.0312) and GLIDE energy (−51.86 kca/mol). The present outcome concludes that ursolic acid possesses significant antioxidant and antiproliferative potential, which can be used in the development of novel antioxidant and antiproliferative agents in the future.

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“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License oleanane, ursane and friedelane (Salvador et al, 2017). In this context, oleanane, ursane and friedelane-types exhibit inhibitory activity against various intra and extracellular targets in eukaryotic cells and proteins that have participation in different processes such as cellular development, differentiation, inflammation, angiogenesis, apoptosis and metastasis (Iqbal et al, 2018;Peron et al, 2018;Ren and Kinghorn, 2019). Thus, they are considered as multitarget agents, acting through several signaling pathway, involved in cancer progression and survival.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of cytotoxic activity of triterpenes from Clusia studartiana

Brito¹,

Carvalho²,

Silva³

et al. 2019

J. Med. Plants Res.

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Family Clusiaceae is spread throughout tropical as well as temperate zones, presenting many triterpenes, reported as selective antitumoral agents. The aim of this study is to isolate and identify triterpenes from Clusia studartiana C. M. Vieira & Gomes da Silva and evaluate their cytotoxicity in melanoma (SKMEL 28) and myeloid leukemia (K562) cell lines. Thus, the hexanic extract was processed by phytochemical methods to isolate and purify the pentacyclic triterpenes: 3-oxo-friedelin (1), 3-βhydroxy-friedelin (2) and 3-oxo-olean-12-en-28-oic-acid (3), identified by spectroscopic methods. Cytotoxicity was evaluated by MTT assay, apoptosis/necrosis by Annexin V/PI, caspase activity by FLICA in flow cytometry and P-gp modulation was measured by interference in the efflux of Rhodamine 123. From the results, triterpenes 2 and 3 showed inhibitory effect in K562 cells proliferation, and only the compound 3 was able to increase percentage of AnnexinV + PI in cells (p<0.05), with 40% increase in caspase 3/7 + cells and showed inhibition on P-gp activity.

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Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications

Cited by 97 publications

References 46 publications

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Evaluation of cytotoxic activity of triterpenes from Clusia studartiana

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