Urorectal Septum Malformation Sequence in A Calf

Köm, Mustafa; Eröksüz, Yesari

doi:10.9775/kvfd.2012.7178

Cited by 1 publication

(2 citation statements)

References 11 publications

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“…With ambiguous internal genitalia, this patient presented with multiple serious malformations in the skeletal system and circulatory, digestive, and urinary organs. In cattle, a series of malformations have often been reported in female pseudohermaphroditism [ 4 – 6 ]. Similar complex intersex and serious malformations have also been reported in one dizygotic twin lamb [ 9 ] and in a foal [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…In cattle, multiple severe malformations have been reported in previous cases of pseudohermaphroditism, particularly in females. In these cases, there was an absence of the anus and tail, a deficit of urethral and vaginal perineal openings, and ambiguous external genitalia [ 4 – 6 ]. Pathological examination also confirmed rectal atresia, internal genitourinary, and skeletal anomalies.…”

Section: Introductionmentioning

confidence: 99%

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Male pseudohermaphroditism in a complex malformed calf born with an acardius amorphus cotwin—a case report

et al. 2023

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Background Male pseudohermaphroditism is a developmental anomaly wherein animals are genetically and gonadally male, but their internal and/or external genitalia resemble those of females. In cattle, pseudohermaphroditism is often accompanied by multiple severe malformations. To the best of our knowledge, this is the first report of male pseudohermaphroditism in a complex malformed calf born with an acardius amorphous cotwin. Case presentation This report describes the case of a three-day-old, male anurous Japanese Black calf born with an acardius amorphous cotwin, complete absence of the tail, agenesis of the anus, separate scrota, and umbilical hernia. Transthoracic echocardiography and computed tomography revealed serious malformations in the skeletal system and the circulatory, digestive, urinary, and genital organs. Necropsy revealed rectal atresia, immature testes, epididymis, and penis, but no male accessory gonads. Histological analyses revealed vaginal- and uterine-like tissues adjacent to or fused to the rectum. Fluorescence in situ hybridization detected X and Y chromosomes, and some cells presented two X-probe signals in the same nucleus. Conclusions In contrast to the male genitalia, the female genitalia derived from the Müllerian ducts were difficult to detect by necropsy in the presented case. Many similar cases may be overlooked in clinical practice.

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