Urologic Outcomes of Children With Hemorrhagic Cystitis After Bone Marrow Transplant at a Single Institution

Au, Jason; Graziano, Christopher; Elizondo, Rodolfo A.; Ryan, Sheila L.; Roth, David R.; Koh, Chester J.; Gonzales, Edmond T.; Tu, Duong D.; Janzen, Nicolette; Naik, Swati; Seth, Abhishek

doi:10.1016/j.urology.2016.10.030

Cited by 6 publications

(14 citation statements)

References 19 publications

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“…In patients with bilateral PN, the mortality rate was 55%, similar to the total mortality rate of severe HC 12 . Another report showed that bilateral PN was not associated with increased mortality, and no deaths were observed that were directly attributed to PN 13 . In patients requiring PCy, the rates of mortality and transfusion requirement were significantly higher than in those who responded to medical therapy.…”

Section: Discussionmentioning

confidence: 62%

“… 12 Another report showed that bilateral PN was not associated with increased mortality, and no deaths were observed that were directly attributed to PN. 13 In patients requiring PCy, the rates of mortality and transfusion requirement were significantly higher than in those who responded to medical therapy. Thus, PCy for severe HC was suggested to be undertaken only after the failure of medical therapy.…”

Section: Discussionmentioning

confidence: 95%

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Successful treatment of BK virus‐associated severe hemorrhagic cystitis with bilateral single‐J ureteral stenting

et al. 2022

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Introduction BK virus‐associated hemorrhagic cystitis is a significant complication of hematopoietic stem cell transplantation. Although severe BK virus‐associated hemorrhagic cystitis is associated with treatment‐related mortality, sufficient evidence regarding its management is lacking. Case presentation A 14‐year‐old boy presented with BK virus‐associated hemorrhagic cystitis and bladder clot retention after hematopoietic stem cell transplantation. Various urological interventions failed to improve cystitis. While bladder clot retention frequently recurred, surgical intervention was difficult because of the underlying hematological disorder. Hence, bilateral single‐J ureteral stenting followed by Foley catheter placement was performed as a urinary diversion. The bladder clot completely disappeared 27 days after stenting. No additional procedure was required. BK virus‐associated hemorrhagic cystitis did not recur after the blood clot disappeared. Conclusion Bilateral single‐J ureteral stenting followed by Foley catheter placement is a simple and effective treatment method and should be considered before surgical intervention for severe BK virus‐associated hemorrhagic cystitis.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 95%

Successful treatment of BK virus‐associated severe hemorrhagic cystitis with bilateral single‐J ureteral stenting

et al. 2022

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“…In pediatric patients, increased mortality is linked to catheterization, the need for dialysis, and the presence of BKV. 9,10 Infective agents were ruled out in this case. Urine culture was negative with no evidence of pus or white cells/ organisms on microscopy.…”

Section: Discussionmentioning

confidence: 89%

“…Long-term effects include bladder and upper tract fibrosis as well as reduced bladder capacity. In pediatric patients, increased mortality is linked to catheterization, the need for dialysis, and the presence of BKV 9,10…”

Section: Discussionmentioning

confidence: 99%

An Unusual Cause of Hemorrhagic Cystitis in a Teenager With Medulloblastoma

Slack¹,

Ray²,

Lee³

et al. 2020

Journal of Pediatric Hematology/Oncology

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Hemorrhagic cystitis is a life-threatening condition in which the transitional epithelium and blood vessels of the bladder necrose leading to severe hematuria, abdominal pain, and voiding lower urinary tract symptoms. Etiology includes chemotherapy (cyclophosphamide, ifosfamide, busulfan), radiotherapy, or infectious agents. We present a pediatric case of a 15-year-old boy with medulloblastoma who developed hemorrhagic cystitis following cisplatin chemotherapy. All other causes were ruled out and it is therefore likely that the agent, in this case, was cisplatin, which has never had hemorrhagic cystitis reported as a side effect. We also suggest a mechanism for urothelial injury centered around OCT-2 receptors.

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“…The increase in this type of transplantations, as well as the significant comorbidity associated with this complication in severe cases -need for urinary diversion or occurrence of urological sequelae -, demonstrate that pediatric urologists have a key role in the cross-disciplinary treatment of these patients (2) . According to when HC occurs from transplantation, it can be divided into two groups (3,4) . One is early HC, which occurs before or a few days following transplantation and often resolves spontaneously.…”

Section: Introductionmentioning

confidence: 99%

Hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation: experience in a pediatric oncological institution

de la Puente,

Espinoza,

Carrillo

et al. 2023

Cir Pediatr

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Objective. To analyze the risk factors associated with hemorrhagic cystitis (HC) severity and the treatment strategies available in HC patients following allogeneic hematopoietic stem cell transplantation (AHSCT). Materials and methods.A retrospective study of medical records was carried out. Patients with HC following AHSCT treated from 2017 to 2021 were divided into two groups according to severity -mild and severe. Demographic data, disease-specific characteristics, urological sequelae, and overall mortality were compared between both groups. The hospital's protocol was used for patient management.Results. 33 episodes of HC were collected in 27 patients, 72.7% of whom were male. HC incidence following AHSCT was 23.4% (33/141). 51.5% of HCs were severe (grades III-IV). Severe graft host disease (GHD) (grades III-IV) and thrombopenia at HC onset were associated with severe HC (p= 0.043 and p= 0.039, respectively). This group had longer hematuria times (p< 0.001) and required more platelet transfusions (p= 0.003). In addition, 70.6% required bladder catheterization, but only 1 case needed percutaneous cystostomy. None of the patients with mild HC required catheterization. No differences were found in terms of urological sequelae or overall mortality.Conclusions. Severe HC could be predicted thanks to the presence of severe GHD or thrombopenia at HC onset. Severe HC can be managed with bladder catheterization in most of these patients. A standardized protocol may help reduce the need for invasive procedures in patients with mild HC.

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Urologic Outcomes of Children With Hemorrhagic Cystitis After Bone Marrow Transplant at a Single Institution

Cited by 6 publications

References 19 publications

Successful treatment of BK virus‐associated severe hemorrhagic cystitis with bilateral single‐J ureteral stenting

Successful treatment of BK virus‐associated severe hemorrhagic cystitis with bilateral single‐J ureteral stenting

An Unusual Cause of Hemorrhagic Cystitis in a Teenager With Medulloblastoma

Hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation: experience in a pediatric oncological institution

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