Urolithiasis in lichen planus

Halevy, Sima

doi:10.1001/archderm.119.5.364b

Cited by 6 publications

(5 citation statements)

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“…Our results demonstrated a 20% prevalence of urolithiasis in patients with LP, which can be considered similar to previous studies ( 6 , 15 ). In 5% of the patients, a renal calculus at the time of presentation was detected.…”

Section: Discussionsupporting

confidence: 92%

“…The 3mm diameter calculuses diagnosed at the time of presentation in 2 patients were clinically insignificant. On the other hand, a history of urolithiasis was mostly experienced before the LP disease, which is similar to the literature ( 6 , 15 ).…”

Section: Discussionsupporting

confidence: 88%

“…To date, a limited number of studies have evaluated the association of urolithiasis and LP ( 6 , 14 - 16 ). Halevy et al reported the coexistence of LP and urolithiasis for the first time in 1983 ( 15 ) From medical records and anamnesis, they found that 14.6% of 130 patients with LP had a history of urolithiasis. They claimed that this incidence was higher than the population of their community.…”

Section: Discussionmentioning

confidence: 99%

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Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

et al. 2016

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Purpose to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not.Patients and Methods We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine.Results Men/women ratio and mean age were similar between group I and II (p>0.05). A presence or history of urolithiasis was detected in 8 (20%) and 2 (%5) patients in group I and II, respectively (p<0.05). Hypocitraturia was the most common anomaly with 35% (n:14) in group I. The rate of hypocitraturia in group II was 12.5% (n:5) and the difference was statistically significantly different (p=0.036). In group I, hyperuricosuria and hyperoxaluria followed with rates of 27.5% (n:11) and 25% (n:10), respectively. The rate of hyperuricosuria and hyperoxaluria were both 5% (n:2) in group II and the differences were significant (p<0.05). Hyperuricemia was another important finding in the patients with LP. It was detected in 13 (32.5%) patients in group I and in 1 (2.5%) participant in group II (p=0.001).Conclusion According to our results, metabolic disorders of urolithiasis were highly detected in the patients with LP. However, similar to the etiology of LP, the exact reasons for these metabolic abnormalities in LP remain a mystery.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

et al. 2016

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“…Recurrent urinary tract infection, though reported to be present more often (33), was seen in only one of our patients and is likely to be a chance finding. One report has suggested a 6to 12-fold increase in urolithiasis in patients with LP (34). In a recent study from our institute, 12% of patients with lichen planus had a history of urolithiasis.…”

Section: Discussionmentioning

confidence: 65%

Lichen Planus: A Clinical and Epidemiological Study

Bhattacharya

Kaur

Kumar

2000

The Journal of Dermatology

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Clinical and epidemiological data from 232 patients with lichen planus is presented. Lichen planus constituted 0.38% of the total dermatology, outpatients diagnosed. The patient ages ranged from 8 to 76 years, most being in the age range from 20 to 49 years. Duration of disease varied from 1 month to 7 years. Both sexes were equally affected. The majority of the patients (47.4%) had classical lesions followed by hypertrophic and actinic lichen planus next in frequency. Itching was the predominant symptom in 79.3%. Limbs were the most frequent initial site of onset (55.6%). Mucosal involvement along with cutaneous lesions were observed in 16.8% and genital involvement in only 5.2%. Nail changes were observed in 15.1% of patients. A history of recurrence of the disease was obtained from 10.3% of patients. Liver disease was found to be associated in 2.2% of patients. No malignant changes were observed in any of the lesions of lichen planus.

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“…Other bowel diseases occasionally described concomitant with LP include coeliac disease (Lundstrom et al, 1982;Fortune and Buchanan, 1993) and Crohn's disease (Kano et al, 1995), though others have not found these associations . (14) MISCELLANEOUS ASSOCIATIONS LP has occasionally been associated with other conditions, including psoriasis (Shiohara et al, 1989;Naldi et al, 1990;Delaney et al, 1993), lichen sclerosis , urolithiasis (Halevy and Feuerman, 1983), agents used to treat gallstones (Ellul et al, 1992), mesangioproliferative glomerulonephritis (Cottoni et al, 1988), erythema dyschromicum (Berger et al, 1989), and Turner's syndrome with endocrinopathies (Kurgansky and Burnett, 1994).…”

Section: (8) Stressmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

467

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Urolithiasis in lichen planus

Cited by 6 publications

References 0 publications

Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

Lichen Planus: A Clinical and Epidemiological Study

Update On Oral Lichen Planus: Etiopathogenesis and Management

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