Urinary neutrophil gelatinase-associated lipocalin and L-type fatty acid binding protein as diagnostic markers of early acute kidney injury after liver transplantation

Li, Yi; Zhu, Mingli; Xia, Qiang; Wang, Siyue; Qian, Jiaqi; Lu, Renhua; Che, Miaolin; Dai, Hongyue; Wu, Qin; Ni, Zhaohui; Lindholm, Bengt; Axelsson, Jonas; Yan, Yucheng

doi:10.3109/1354750x.2012.672458

Cited by 28 publications

(36 citation statements)

References 36 publications

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“…For this comparison, we measured creatinine in our urine samples using a modified Jaffe reaction on a Siemens Xpand plus HM Clinical Analyzer (Siemens, Munich, Germany). While the cutoff values in most studies analyzed were under 100 ng/mg creatine (range, 25–89 ng/mg), two studies were much higher, from 486 ng/mg [37] to 3,452 ng/mg [38]. The timing of the sampling may be of importance, since most renal biomarkers have distinct patterns of elevation post-surgery [17], but there was no specific trend in the timing of the samples in the meta-analysis that could explain such a large range of cutoffs.…”

Section: Discussionmentioning

confidence: 99%

Pediatric reference ranges for acute kidney injury biomarkers

et al. 2014

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Background Novel urinary biomarkers are useful for the prediction of acute kidney injury (AKI). Most promising are the urine markers NGAL, IL-18, KIM-1, and LFABP. Each of these has shown considerable promise diagnosing AKI earlier than serum creatinine (Scr) using disease controls. We set out to determine reference levels of these markers in a healthy pediatric population. Methods Urine was collected from 368 healthy children and assayed for NGAL, IL-18, KIM-1, and LFABP using commercially available kits or assay materials. Analysis of biomarkers by linear regression and according to age groups (3–<5 years; 5–<10; 10–<15; 15–<18) was performed to determine if biomarker levels differed with age and gender. Results Median values were: NGAL (6.6 ng/ml; IQR 2.8–17), IL-18 (21.6 pg/ml; IQR 13.6–32.9), KIM-1 (410 pg/ml; IQR 226–703), LFABP (3.4 ng/ml; IQR 1.6–6.0). Significant gender differences were found with NGAL and IL-18 and significant age differences were found with all markers. 95th percentile values for each marker varied with age and gender greater than median values. Conclusions This is the largest pediatric reference range study for the urinary measurement of NGAL, IL-18, KIM-1, and LFABP and highlights age and gender differences in these markers. This information is essential for rational interpretation of studies and clinical trials utilizing these emerging AKI biomarkers.

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Section: Discussionmentioning

confidence: 99%

Pediatric reference ranges for acute kidney injury biomarkers

et al. 2014

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“…The level of urinary NGAL presented differences at 2–6 h and urinary L-FABP at 4 h between AKI and non-AKI patients. This study concluded that urinary NGAL rather than L-FABP appeared to be a sensitive and specific marker of AKI in liver transplant recipients [108]. …”

Section: Liver-type Fatty Acid Binding Protein (L-fabp)mentioning

confidence: 99%

New Biomarkers for the Quick Detection of Acute Kidney Injury

2013

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Acute kidney injury (AKI) is a common and strong problem in the diagnosis of which based on measurement of BUN and serum creatinine. These traditional methods are not sensitive and specific for the diagnosis of AKI. AKI is associated with increased morbidity and mortality in critically ill patients and a quick detection is impossible with BUN and serum creatinine. A number of serum and urinary proteins have been identified that may messenger AKI prior to a rise in BUN and serum creatinine. New biomarkers of AKI, including NGAL, KIM-1, cystatin-C, IL-18, and L-FABP, are more favourable tests than creatinine which have been identified and studied in several experimental and clinical training. This paper will discuss some of these new biomarkers and their potential as useful signs of AKI. We searched the literature using PubMed and MEDLINE with acute kidney injury, urine, and serum new biomarkers and the articles were selected only from publication types in English.

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“…66 In addition, Li et al, 98 who studied the behavior of NGAL and L-FABP in liver transplant recipients, concluded that L-FABP is not a marker of AKI in liver transplant recipients.…”

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confidence: 99%

“…Li et al 98 investigated whether NGAL and L-FABP (liver-type fatty acid binding protein) could be good markers for an early diagnosis of AKI in liver transplanted patients. The two markers were detected in the urine of 25 patients 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, and 120 hours after the hepatic transplantation.…”

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confidence: 99%

The potential use of biomarkers in predicting contrast-induced acute kidney injury

Andreucci¹,

Faga²,

Riccio³

et al. 2016

IJNRD

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Contrast-induced acute kidney injury (CI-AKI) is a problem associated with the use of iodinated contrast media, causing kidney dysfunction in patients with preexisting renal failure. It accounts for 12% of all hospital-acquired kidney failure and increases the length of hospitalization, a situation that is worsening with increasing numbers of patients with comorbidities, including those requiring cardiovascular interventional procedures. So far, its diagnosis has relied upon the rise in creatinine levels, which is a late marker of kidney damage and is believed to be inadequate. Therefore, there is an urgent need for biomarkers that can detect CI-AKI sooner and more reliably. In recent years, many new biomarkers have been characterized for AKI, and these are discussed particularly with their use in known CI-AKI models and studies and include neutrophil gelatinase-associated lipocalin, cystatin C (Cys-C), kidney injury molecule-1, interleukin-18, N-acetyl-β-d-glucosaminidase, and L-type fatty acid-binding protein (L-FABP). The potential of miRNA and metabolomic technology is also mentioned. Early detection of CI-AKI may lead to early intervention and therefore improve patient outcome, and in future any one or a combination of several of these markers together with development in technology for their analysis may prove effective in this respect.

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Urinary neutrophil gelatinase-associated lipocalin and L-type fatty acid binding protein as diagnostic markers of early acute kidney injury after liver transplantation

Cited by 28 publications

References 36 publications

Pediatric reference ranges for acute kidney injury biomarkers

Pediatric reference ranges for acute kidney injury biomarkers

New Biomarkers for the Quick Detection of Acute Kidney Injury

The potential use of biomarkers in predicting contrast-induced acute kidney injury

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