Urinary Metabolomics Revealed Arsenic Internal Dose-Related Metabolic Alterations: A Proof-of-Concept Study in a Chinese Male Cohort

Zhang, Jie; Shen, Heqing; Wang, Xu; Xia, Yankai; Barr, Dana Boyd; Mu, Xiaoli; Wang, Xiaoxue; Liu, Liangpo; Huang, Qingyu; Tian, Meiping

doi:10.1021/es503659w

Cited by 74 publications

(52 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Emory University’s NIEHS-funded Human Exposome Research Center: Understanding Lifetime Exposures (HERCULES) has developed infrastructure that has supported several environmental health studies using hybrid biomonitoring approaches (Go et al 2014, 2015; Jones 2016; Zhang et al 2014). HELIX also uses a hybrid approach for data collection.…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring in the Era of the Exposome

Dennis

Marder

Balshaw

et al. 2017

Environ Health Perspect

Self Cite

189

146

View full text Add to dashboard Cite

Background:The term “exposome” was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts.Objectives:Our objectives were to describe why traditional and nontraditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and to make recommendations on how to transition exposure research toward exposomic approaches. We describe the biomonitoring needs of exposome research and approaches and recommendations that will help fill the gaps in the current science.Discussion:Traditional and exposomic biomonitoring approaches have key advantages and disadvantages for assessing exposure. Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources. Issues of sample availability and quality, identification of unknown analytes, capture of nonpersistent chemicals, integration of methods, and statistical assessment of increasingly complex data sets remain challenges that must continue to be addressed.Conclusions:To understand the complexity of exposures faced throughout the lifespan, both traditional and nontraditional biomonitoring methods should be used. Through hybrid approaches and the integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome.Citation:Dennis KK, Marder E, Balshaw DM, Cui Y, Lynes MA, Patti GJ, Rappaport SM, Shaughnessy DT, Vrijheid M, Barr DB. 2017. Biomonitoring in the era of the exposome. Environ Health Perspect 125:502–510; http://dx.doi.org/10.1289/EHP474

show abstract

Section: Discussionmentioning

confidence: 99%

Biomonitoring in the Era of the Exposome

Dennis

Marder

Balshaw

et al. 2017

Environ Health Perspect

Self Cite

189

146

View full text Add to dashboard Cite

show abstract

“…A metabolomic study carried out in the general Chinese population identified several potential biomarkers of iAs exposure in urine (Zhang et al , 2014). Similarly, our recently published metabolomic analyses of urine and plasma from residents of Chihuahua, Mexico found 132 metabolites that were altered in iAs-exposed individuals (Martin et al , 2015).…”

Section: Introductionmentioning

confidence: 99%

Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure

Huang

Douillet

et al. 2016

Arch Toxicol

View full text Add to dashboard Cite

Arsenic (+3 oxidation state) methyltransferase (As3mt) is the key enzyme in the pathway for methylation of inorganic arsenic (iAs). Altered As3mt expression and AS3MT polymorphism have been linked to changes in iAs metabolism and in susceptibility to iAs toxicity in laboratory models and in humans. As3mt-knockout mice have been used to study the association between iAs metabolism and adverse effects of iAs exposure. However, little is known about systemic changes in metabolism of these mice and how these changes lead to their increased susceptibility to iAs toxicity. Here, we compared plasma and urinary metabolomes of male and female wild-type (WT) and As3mt-KO (KO) C57BL6 mice and examined metabolomic shifts associated with iAs exposure in drinking water. Surprisingly, exposure to 1 ppm As elicited only small changes in the metabolite profiles of either WT or KO mice. In contrast, comparisons of KO mice with WT mice revealed significant differences in plasma and urinary metabolites associated with lipid (phosphatidylcholines, cytidine, acyl-carnitine), amino acid (hippuric acid, acetylglycine, urea), and carbohydrate (L-sorbose, galactonic acid, gluconic acid) metabolism. Notably, most of these differences were sex-specific. Sex-specific differences were also found between WT and KO mice in plasma triglyceride and lipoprotein cholesterol levels. Some of the differentially changed metabolites (phosphatidylcholines, carnosine, and sarcosine) are substrates or products of reactions catalyzed by other methyltransferases. These results suggest that As3mt KO alters major metabolic pathways in a sex-specific manner, independent of iAs treatment, and that As3mt may be involved in other cellular processes beyond iAs methylation.

show abstract

“…Interaction between alcohol use and arsenic exposure has been studied among others by Bae et al (2013), Wadhwa et al (2013), and Zhang et al (2014). To the best of our knowledge, we do not know of a study in general U.S. population that has considered the interacting effect of arsenic exposure with smoking, alcohol, and caffeine consumption.…”

Section: Introductionmentioning

confidence: 99%