Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients

Suzuki, Go; Ichibayashi, Ryo; Yamamoto, Satoshi; Serizawa, Hibiki; Nakamichi, Yoshimi; Watanabe, Masayuki; Honda, Masashi

doi:10.1080/0886022x.2021.1943439

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…The baseline levels of NGAL, KIM-1, L-FABP1 and VNN-1 may be in uenced by various confounding factors in patients including acute infections, chronic obstructive pulmonary disease, diabetes mellitus, pancreatitis, heart failure, injury to the epithelial cells of different organs, surgical intervention and various in ammatory and brotic diseases [41,42,43,44]. Nevertheless, even though patients with a history of these morbidities were not included in our study, it appears to be reasonable to compare the measured values of these biomarkers at speci c time points with the baseline, in order to identify chemotherapyinduced AKI.…”

Section: Discussionmentioning

confidence: 99%

Integrated urinary biomarkers can predict early acute kidney injury in children undergoing chemotherapy

Miloševski-Lomić,

Kotur-Stevuljević,

Paripović

et al. 2023

Preprint

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Background Acute kidney injury (AKI) is a common complication in pediatric oncology patients, most often caused by nephrotoxic drugs. We aimed to assess whether levels of urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), liver fatty acid binding protein (L-FABP) and Vanin-1 (VNN-1) could be early biomarkers for cytotoxic treatment induced AKI. Material and methods Children with different malignant diseases treated with cisplatin (CIS) or ifosfamide (IFO) were included. AKI was defined as at least 25% decrease in the estimated glomerular filtration rate (eGFR) by comparing baseline pretreatment eGFR value with the value acquired at 48h after the first or second chemotherapy cycle. Five serum and four urine samples were obtained immediately before and at 2h, 6h, 24h and 48h after treatment. Results Out of 38 patients, 12 (31.58%) experienced AKI within 2 days following the chemotherapy. A model of integrated parameters measured in urine showed significant diagnostic accuracy of pretreatment urine biomarkers (AUC 0.753), urine biomarkers measured 24 h after chemotherapy (AUC 0.712), as well as the ratio of urinary biomarkers measured 24h after chemotherapy adjusted according to urine creatinine concentrations compared to baseline (24 h/baseline ratios) (AUC 0.718) towards AKI prediction. Conclusion Our study suggests that the changes in urinary NGAL/creatinine, KIM-1/creatinine, L-FABP/creatinine and VNN-1/creatinine ratios, 24 h after CIS and/or IFO administration can be utilized to predict AKI in children undergoing chemotherapy. The use of model of integrated urine biomarkers could be a promising to predict AKI in patients receiving CIS and/or IFO containing chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Integrated urinary biomarkers can predict early acute kidney injury in children undergoing chemotherapy

Miloševski-Lomić,

Kotur-Stevuljević,

Paripović

et al. 2023

Preprint

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“…Fatty acid-binding protein 1 is another early biomarker of AKI and can predict the need for dialysis [ 55 ]. An increased level of L-FABP at the time of ICU admission is associated with higher risk of AKI and mortality rate [ 56 , 57 ]. The NGAL and L-FABP combination can predict renal recovery after AKI (higher levels associated with non-recovery) [ 58 ].…”

Section: Tubular Injury Markersmentioning

confidence: 99%

Kidney Injury in Children after Hematopoietic Stem Cell Transplant

2023

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Hematopoietic cell transplant (HCT), used for treatment of many malignant and non-malignant pediatric diseases, is associated with serious complications, limiting this therapy’s benefit. Acute kidney injury (AKI), seen often after HCT, can occur at different stages of the transplant process and contributes to morbidity and mortality after HCT. The etiology of AKI is often multifactorial, including kidney hypoperfusion, nephrotoxicity from immunosuppressive and antimicrobial agents, and other transplant-related complications such as transplant-associated thrombotic microangiopathy and sinusoidal obstructive syndrome. Early recognition of AKI is crucial to prevent further AKI and associated complications. Initial management includes identifying the etiology of AKI, preventing further kidney hypoperfusion, adjusting nephrotoxic medications, and preventing fluid overload. Some patients will require further support with kidney replacement therapy to manage fluid overload and AKI. Biomarkers of AKI, such as neutrophil gelatinase-associated lipocalin can aid in detecting AKI before a rise in serum creatinine, allowing earlier intervention. Long-term kidney dysfunction is also prominent in this population. Therefore, long-term follow-up and monitoring of renal function (glomerular filtration rate, microalbuminuria) is required along with management of hypertension, which can contribute to chronic kidney disease.

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Association of urinary liver-type fatty acid–binding protein with outcomes after adrenalectomy for unilateral primary aldosteronism

Chen

et al. 2023

Clinica Chimica Acta

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Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients

Abstract: 2021) Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients,

Cited by 5 publications

References 28 publications

Integrated urinary biomarkers can predict early acute kidney injury in children undergoing chemotherapy

Integrated urinary biomarkers can predict early acute kidney injury in children undergoing chemotherapy

Kidney Injury in Children after Hematopoietic Stem Cell Transplant

Association of urinary liver-type fatty acid–binding protein with outcomes after adrenalectomy for unilateral primary aldosteronism

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