Urinary Flow and Excretion of Solutes During Osmotic Diuresis in Hydropenic Man

The Mechanism of Polyuria of Diabetes Insipidus in Man. The Effect of Osmotic Loading

“…osmolarity decreased to a value of 511 mOsm./L. The results were essentially the same as those observed in normal hydropenic subjects after mannitol loading (6).…”

“…Solute loading had little effect on potassium excretion in the subjects of the present study as observed previously in normal subjects (10). Mannitol excretion, not plotted, accounted for the same percentage of urinary solutes (50-60%b) as it did in normal subjects (6).…”

On the Role of the Kidney during Nephrotic Edema: Potassium Excretion and Sodium Retention 1

“…In the control subjects, potassium excretion was increased three to five times during the hypertonic sodium loads, as previously demonstrated (11)(12)(13)18). Quantitatively, the level of potassium excretion was about one-third to one-fifth that of sodium (Table I).…”

“…In 0% in 0 0% U) 00 1.. Solute diuresis In the control individual, urine flows directly proportional to excretion of non-reabsorbed solutes are one feature of solute diuresis (13). This was true also in the edematous nephrotic child.…”

“…When the sodium salt of a non-reabsorbable anion is infused in the normal subject, the anion is promptly excreted with an almost equivalent amount of sodium (13)(14)(15)(16). Since the edematous nephrotic patient has some limitation in the rapid excretion of sodium, it might be expected that a non-reabsorbable anion load would place the cellular cation exchange mechanisms in the renal tubule under stress.…”