Urinary Estrogens

Hobkirk, R.; Metcalfe-Gibson, A; Kase, Nathan; RICHARDSON, EDWARD

doi:10.1016/b978-1-4831-9685-5.50015-7

Cited by 12 publications

(6 citation statements)

References 20 publications

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“…Urinary 17-ketosteroids [13] were increased at 64 mg/day with Porter-Silber chromogens [20] at 2.9 and I l-desoxycortisol metabolites [II] at 0.23 mg/day. Urinary estrogens [12] were greatly increased at 564 «g/day while pregnanediol [15] and pregnanetriol [2] excretion was slightly elevated at 13 and 7.5 mg/day. Urinary aldosterone [14] was normal at 8 , «g/day (table I).…”

Section: Resultsmentioning

confidence: 98%

17(OH)Corticosteroid and Estrogen Excretion with Virilizing Adrenal Tumors

et al. 1973

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In an adult with a virilizing adrenocortical adenoma and in six similar published instances, the high levels of urinary 17-ketosteroids usually present were associated with normal excretion of 17(OH)corticosteroids or Porter-Silber chromogens. Urinary estrogens were high in 1 of 3 patients. In 5 of 9 adult patients assembled from the literature virilization in association with an adrenal cancer was characterized by increased levels of urinary 17(OH)corticosteroids; also, urinary estrogens were high in each of the 4 patients in whom they were measured. The above data point to a variety of enzyme patterns of steroidogenesis in association with virilizing adrenal tumors in adults. Thus, in those with an adenoma, desmolase activity is increased with high androgen production from 17(OH)steroids and normal or high estrogen formation from androgens without an increase in 17(OH)corticosteroid excretion. In those with an adrenal cancer, 17(OH)corticosteroid output is increased in about one half, androgen synthesis is of course always high, and, judging from the cases cited, estrogen production is invariably high. The basal levels of urinary 17-ketosteroids appear to be of no aid in the identification of virilization in adults due to an adrenal adenoma and that resulting from an adrenal cancer. The data indicate that cancer is more likely if in addition to high urinary 17-ketosteroids, the levels of 17(OH)corticosteroids and of estrogens are abnormally elevated in urine.

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Section: Resultsmentioning

confidence: 98%

17(OH)Corticosteroid and Estrogen Excretion with Virilizing Adrenal Tumors

et al. 1973

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Section: Resultsmentioning

confidence: 99%

“…The tests for postural hypotension (blood pressure in the lying, sitting, and standing positions), vibratory sense (per-3 months X ± SD (n) t33.4 ± 12.8 (16) t7.3 ± 3.7 (16) t24.7 ± 11.9 (16) t3.8 ± 3.1 (16) "9.7 ± 0.4 (16) "9.3 ± 0.5 (16) t3.4 ± 0.4 (12) t2.9 ± 0.3 (12) "122 ± 51 (16 6 months X ± SD (n) t35.5 ± 14.4 (14) t5.9 ± 3.3 (14) t22.7 ± 11.6 (14) H.3 ± 4.3 (14) t9.7 ± 0.4 (16) t9.2 ± 0.4 (16) t3.4 ± 0.4 (16) *2.8 ± 0.4 (16) t122 ± 51 (16) t182 ± 73 (16) "315 ± 46 (10) "441 ± 133 (10) t4.0 ± 0.8 (11) t6.8 ± 0.8 (11) 6 months X ± SD (n) "2l.6 ± 13.2 (15) "30.2 ± 8.3 (15) Quingestanol-quinestrol etfects 9 months X ± SD (n) *34.4 ± 14.5 (13) t6.2 ± 4.4 (13) *20.2 ± 11.7 (11) t4.3 ± 3.5 (11) t9.7 ± 0.4 (12) t9.2 ± 0.6 (12) t3.4 ± 0.4 ( 8) t2.8 ± 0.2 ( 8) fl23 ± 53 (12) tl66 ± 49 (12) "337 ± 53 (11) "472 ± 86 (11) H.3 ± 0.8 ( 9) *6.3 ± 0.7 ( 9)…”

Section: Resultsmentioning

confidence: 99%

Ether derivatives of a progestin and estrogen in monthly dosage

Danowski

Wilson

Vester

et al. 1973

Clin Pharma and Therapeutics

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“…A response to metyrapone was still present on day 1 in that Porter-Silber chromogens and 11-desoxycortisol metabolites did increase but to a lesser degree. The 17-ketosteroid and Porter-Silber chromogen responses on day 2 were equal in the tests performed before and during quingestanol treatment, Fasting insulin (/tU/ml)3 32 ± 32 (17) 27 ± 42 (17) Al0 -2 h ' 272 ± 336 (17) 154 ± 181 (17) Al0 - * Fasting insulin = zero-hour serum insulin value. 6 Al = Ainsulin.…”

Section: Discussionmentioning

confidence: 99%

“…The basal urinary 17-ketosteroids [18], Porter-Silber chromogens [28], 11-desoxycortisol or compound S metabolites [15] (table IV), and the total estrogens [17] also remained in the pretreatment range. …”

Section: Proteinuria Creatinine Clearance and Urinary Steroidsmentioning

confidence: 99%

Effects of a Progestin, Quingestanol, in Older Diabetic Women

Danowski¹,

Wilson²,

Khurana³

et al. 1973

Horm Res

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Quingestanol acetate (17-α-ethynyl-19-nortestosterone acetate, 3-cyclopentylenol ether), a synthetic progestational steroid, was well tolerated at a dosage of 300 µg/day per os by 17 diabetic women who, with but one exception, were between 50 and 65 years of age and had ceased menstruating. Body weight, systolic and diastolic blood pressure, and the pulse rate were of the same orders of magnitude prior to and during the 12 months of quingestanol treatment. The diabetes mellitus was not affected but oscillometric readings at certain body points decreased during the year of treatment, probably reflecting the natural course of vascular disease in diabetic individuals.Despite changes in certain laboratory indices, i.e. slight increases of variable but usually short duration in serum sodium, chloride, total globulins and their α₂, β- and γ-fractions, SGOT, SGPT, LDH, FSH, chylomicrons, and blood platelets and the decreases in serum potassium, albumin, α₁-globulin, nonesterified fatty acids, β-lipoproteins, and plasma ll(OH)corticosteroids, most of the values remained within the ranges established for normal persons. One year of quingestanol therapy was associated with decreased first-day responses to metyrapone. This suggests, among other possibilities, that quingestanol inhibits the hypothalamic-pituitary controlled output of ACTH.All of the other items monitored during this course of quingestanol therapy remained unchanged.

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Urinary Estrogens

Cited by 12 publications

References 20 publications

17(OH)Corticosteroid and Estrogen Excretion with Virilizing Adrenal Tumors

17(OH)Corticosteroid and Estrogen Excretion with Virilizing Adrenal Tumors

Ether derivatives of a progestin and estrogen in monthly dosage

Effects of a Progestin, Quingestanol, in Older Diabetic Women

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