Urinary Concentrations of Parabens and Serum Hormone Levels, Semen Quality Parameters, and Sperm DNA Damage

Meeker, John D.; Yang, Tiffany; Ye, Xiaoyun; Calafat, Antònia M.; Hauser, Russ

doi:10.1289/ehp.1002238

Cited by 309 publications

(192 citation statements)

References 42 publications

Supporting

Mentioning

170

Contrasting

Unclassified

Order By: Relevance

“…The epidemiological studies investigating a link between male BPA exposure and inhibin B levels are far from providing a clear picture. Urinary BPA was found to be inversely associated with inhibin B levels measured in the serum of the male partners in subfertile couples (Meeker et al, 2011). Furthermore, male workers in the highest quartile of BPA measurements had lower inhibin B levels (Liu et al, 2015).…”

Section: Inhibin Bmentioning

confidence: 90%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

View full text Add to dashboard Cite

WHAT IS KNOWN ALREADY:The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. STUDY DESIGN, SIZE, DURATION:Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB), and bisphenol A diglycidyl ether (BADGE) at 10 -9 to 10 -5 M for 24 h or 48h.PARTICIPANTS/MATERIALS, SETTING, METHODS: Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase 3 immunohistochemistry), and the levels of testosterone, insulin-like fator 3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). MAIN RESULTS AND THE ROLE OF CHANCE: A significant dose-dependent inhibition wasfound between testosterone levels measured in the culture medium and concentrations of BPA The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. WIDER IMPLICATIONS OF THE FINDINGS:Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.

show abstract

Section: Inhibin Bmentioning

confidence: 90%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…After exposure, environmental phenols, like any other non-persistent compounds, have short halflives (~6-12 hours). Therefore, concentrations of these compounds in spot samples (urine or serum/plasma) primarily reflect exposure(s) which occurred within a relatively short period preceding sample collection (58) and there is considerable temporal variability of concentrations in spot samples (59,60). The variability of serum concentrations from spot sampling plus the higher concentrations of some phenols in non-Hispanic blacks may have contributed to the higher standard errors for this particular ethnic group.…”

Section: Discussionmentioning

confidence: 99%

Concentrations of Bisphenol A and Seven Other Phenols in Pooled Sera from 3–11 Year Old Children: 2001–2002 National Health and Nutrition Examination Survey

Zhou

Wong

et al. 2012

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Concerns exist regarding children's exposure to bisphenol A (BPA) and other phenols because of the higher sensitivity, compared to adults, of children's developing organs to endocrine disruptors. Several studies reported the urinary concentrations of these phenols in children, but data on levels of these compounds in children's serum are limited. We present here the total (free plus conjugated) and free concentrations of BPA and seven other phenols in 24 pooled serum samples prepared from individual specimens collected from 936 children 3-11 years old who participated in the 2001-2002 National Health and Nutrition Examination Survey. We detected benzophenone-3, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, and three parabens in at least 60% of the pools suggesting children's exposure to these compounds or their precursors. Conjugated phenols were the major species. However, although many previous studies have shown widespread detection of BPA in children's urine, we only detected total or free BPA in 3 and 2 pooled serum samples, respectively, at concentrations of 0.1-0.2 µg/L. The non-persistent nature of BPA and the phenols examined and the likely episodic nature of the exposures to these compounds (or their precursors) suggest that for general population biomonitoring of these nonpersistent phenols, urine, not serum or plasma, is the preferred matrix.

show abstract

“…Epidemiological studies have shown an association between human exposure to parabens and adverse health outcomes (Meeker et al 2011;Savage et al 2012). In March 2011, Denmark has banned the application of propyl paraben, butyl paraben, and their salts in cosmetic products for children under 3 years old (Asimakopoulos et al 2014).…”

Section: Responsible Editor: Hongwen Sunmentioning

confidence: 99%

Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools

Shi

Gao

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

As an emerging group of endocrine-disrupting chemicals, parabens have attracted growing attention due to their potential effects on human health. In the present study, the occurrence and distribution of eight parabens, four chlorinated parabens, and their common hydrolysis product, phydroxybenzoic acid (PHBA), were investigated in 39 swimming pools in Beijing, China. Methyl paraben and propyl paraben were the predominant compounds in swimming pools, accounting for 91.2 % of the total parabens. It is noteworthy that octyl paraben, a paraben with longer chain, was firstly detected in this study. There were several factors affecting the levels of parabens among the 39 swimming pools. The concentrations of parabens and chlorinated derivatives detected in indoor pools (144 ng L −1 ) were roughly 20-fold higher than those in outdoor pools (6.78 ng L −1 ). Hotel pools appear to present higher level of target compounds (361 ng L −1 ) than that in health club (228 ng L −1 ), municipal (130 ng L −1 ), school (75.6 ng L −1 ), and community pools (63.0 ng L −1 ). Moreover, the level of these compounds in pools during weekends (174 ng L −1 ) was much higher than that during weekdays (52.3 ng L −1 ). The dynamics of target compounds were also investigated to provide a general trend of the level of parabens in a school indoor swimming pool during a 14-week period. Human exposure assessment was conducted to estimate the potential risk of exposure to parabens and their chlorinated derivatives in swimming pools. Considering the total exposure dose of multiple parabens, human exposure to parabens from the water of swimming pools is negligible. However, the threat of these parabens to children in swimming pool should be concerned.

show abstract

Urinary Concentrations of Parabens and Serum Hormone Levels, Semen Quality Parameters, and Sperm DNA Damage

Cited by 309 publications

References 42 publications

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Concentrations of Bisphenol A and Seven Other Phenols in Pooled Sera from 3–11 Year Old Children: 2001–2002 National Health and Nutrition Examination Survey

Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools

Contact Info

Product

Resources

About